Attenuated Nitric Oxide Synthase Activity and Protein Expression Accompany Intestinal Ischemia/Reperfusion Injury in Rats
Khanna A, Rossman J, Fung H, Caty M. Attenuated Nitric Oxide Synthase Activity and Protein Expression Accompany Intestinal Ischemia/Reperfusion Injury in Rats. Biochemical And Biophysical Research Communications 2000, 269: 160-164. PMID: 10694494, DOI: 10.1006/bbrc.2000.2266.Peer-Reviewed Original ResearchConceptsNitric oxide synthase activityOxide synthase activityNOS activityReactive oxygen speciesIntestinal ischemia/reperfusion injuryIntestinal ischemia/reperfusionIschemia/reperfusion injuryInhibits neutrophil activationNOS III expressionSuperior mesenteric ischemiaIschemia/reperfusionEndogenous NO formationIntestinal tissue homogenatesWestern blot analysisIntestinal ischemiaMesenteric ischemiaNeutrophil infiltrationR injuryReperfusion injuryDeleterious stimuliNeutrophil activationSynthase activityIntestinal integrityAnimal modelsL-arginine