Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes
Espitia CM, Saldarriaga OA, Travi BL, Osorio EY, Hernandez A, Band M, Patel MJ, Medina AA, Cappello M, Pekosz A, Melby PC. Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes. BMC Immunology 2014, 15: 38. PMID: 25424735, PMCID: PMC4253007, DOI: 10.1186/s12865-014-0038-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCluster AnalysisCricetinaeCytokinesDisease ProgressionDNA, ComplementaryExpressed Sequence TagsGene Expression ProfilingGene Expression RegulationGene OntologyHumansInterferon-gammaLeishmania donovaniLeishmaniasis, VisceralMesocricetusMolecular Sequence AnnotationOligonucleotide Array Sequence AnalysisPrincipal Component AnalysisRNA, MessengerSignal TransductionSpleenUp-RegulationConceptsSyrian golden hamstersVisceral leishmaniasisHamster modelGolden hamstersProgressive visceral leishmaniasisIL-4/ILIFN-γ responsesAlternative macrophage activationProgression of diseaseStudy of immunopathogenesisHamster infection modelPolarization of macrophagesImmune cell traffickingImmune response genesImmune-related genesSpleen responseImmunopathological featuresMassive splenomegalyInfected groupMacrophage activationIntracellular protozoanCell traffickingType 1Infection modelLeishmaniasis