2008
Mucosal antibody responses in experimental hookworm infection
BUNGIRO RD, SUN T, HARRISON LM, SHOEMAKER CB, CAPPELLO M. Mucosal antibody responses in experimental hookworm infection. Parasite Immunology 2008, 30: 293-303. PMID: 18312503, DOI: 10.1111/j.1365-3024.2008.01023.x.Peer-Reviewed Original ResearchConceptsMucosal IgA responsesSystemic immune responsesIgA responsesImmune responseHookworm infectionInfected hamstersRobust systemic immune responseAncylostoma ceylanicum infectionExperimental hookworm infectionFecal IgA responsesParasite-specific IgAMucosal immune responsesMucosal antibody responsesIntestinal worm burdenExcretory-secretory productsMucosal antibodiesProtective immunityChallenge infectionSerum IgGAntibody responsePrimary infectionSecretory IgAHamster modelIntestinal mucosaWorm burden
2007
Structural and Functional Characterization of a Secreted Hookworm Macrophage Migration Inhibitory Factor (MIF) That Interacts with the Human MIF Receptor CD74*
Cho Y, Jones BF, Vermeire JJ, Leng L, DiFedele L, Harrison LM, Xiong H, Kwong YK, Chen Y, Bucala R, Lolis E, Cappello M. Structural and Functional Characterization of a Secreted Hookworm Macrophage Migration Inhibitory Factor (MIF) That Interacts with the Human MIF Receptor CD74*. Journal Of Biological Chemistry 2007, 282: 23447-23456. PMID: 17567581, PMCID: PMC3707627, DOI: 10.1074/jbc.m702950200.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAncylostomaAnimalsAntigens, Differentiation, B-LymphocyteCricetinaeCytokinesHistocompatibility Antigens Class IIHumansIntestinal MucosaMacrophage Migration-Inhibitory FactorsMesocricetusMolecular Sequence DataProtein BindingRabbitsRecombinant ProteinsSequence Homology, Amino AcidConceptsMacrophage migration inhibitory factorMIF receptor CD74Migration inhibitory factorReceptor CD74Inhibitory factorHost immune responseHuman macrophage migration inhibitory factorMIF proteinHookworm Ancylostoma ceylanicumImmune responseDisease pathogenesisHuman cytokinesMacrophage migrationAncylostoma ceylanicumMajor causeWorm survivalParasite survivalISO-1Significant differencesTautomerase activityHookworm proteinsCytokinesCD74HookwormRelative bioactivity