2004
Ancylostoma ceylanicum anticoagulant peptide-1: role of the predicted reactive site amino acid in mediating inhibition of coagulation factors Xa and VIIa
Mieszczanek J, Harrison LM, Cappello M. Ancylostoma ceylanicum anticoagulant peptide-1: role of the predicted reactive site amino acid in mediating inhibition of coagulation factors Xa and VIIa. Molecular And Biochemical Parasitology 2004, 137: 151-159. PMID: 15279961, DOI: 10.1016/j.molbiopara.2004.05.011.Peer-Reviewed Original ResearchConceptsCoagulation factor XaAmino acid sequence similarityFactor XaGastrointestinal blood lossIron deficiency anemiaSite amino acid residuesAmino acid residuesSite amino acidsMechanism of actionBlood lossHookworm infectionSequence similarityDeficiency anemiaLeading causeFactor VIIa/tissue factor complexFactor complexCoagulation inhibitorsPeptide-1Ancylostoma caninum anticoagulant peptide 5Coagulation responseAcid residuesNon-active siteA. ceylanicumAnticoagulantsTissue factor complexFormation of tissue factor–factor VIIa–factor Xa complex promotes cellular signaling and migration of human breast cancer cells
Jiang X, Bailly M, Panetti T, Cappello M, Konigsberg W, Bromberg M. Formation of tissue factor–factor VIIa–factor Xa complex promotes cellular signaling and migration of human breast cancer cells. Journal Of Thrombosis And Haemostasis 2004, 2: 93-101. PMID: 14717972, DOI: 10.1111/j.1538-7836.2004.00545.x.Peer-Reviewed Original ResearchConceptsHuman breast cancer cellsMAPK phosphorylationCellular signalingBreast cancer cellsCell migrationCancer cellsCell linesTF-FVIIa complex formationProtein kinase phosphorylationTumor cell migrationConcentrations of FVIIaKinase phosphorylationTranscriptase-polymerase chain reaction analysisP44/42 mitogenTissue factorPhosphorylationTransmembrane glycoproteinReverse transcriptase-polymerase chain reaction analysisProtease-activated receptor 1TF-FVIIaSpecific agonist peptideChain reaction analysisSignalingPhysiological consequencesPathway
1999
Cancer and blood coagulation: molecular aspects.
Bromberg M, Cappello M. Cancer and blood coagulation: molecular aspects. The Cancer Journal 1999, 5: 132-8. PMID: 10367166.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1998
Ancylostoma caninum Anticoagulant Peptide Blocks Metastasis In Vivo and Inhibits Factor Xa Binding to Melanoma Cells In Vitro
Donnelly K, Bromberg M, Milstone A, Madison McNiff J, Terwilliger G, Konigsberg W, Cappello M. Ancylostoma caninum Anticoagulant Peptide Blocks Metastasis In Vivo and Inhibits Factor Xa Binding to Melanoma Cells In Vitro. Thrombosis And Haemostasis 1998, 79: 1041-1047. PMID: 9609244, DOI: 10.1055/s-0037-1615117.Peer-Reviewed Original ResearchConceptsAnti-metastatic activityThrombin generationAntimetastatic effectFactor XaEffector cell protease receptor-1Melanoma cellsTissue factor pathway inhibitorDose-dependent reductionFactor pathway inhibitorHuman coagulation factor XaHuman melanoma cellsFactor V/VaPulmonary metastasesSubcutaneous injectionSCID miceCoagulation factor XaVein injectionBlock metastasisReceptor 1Inhibits factor XaPathway inhibitorTumor cellsXa concentrationsProthrombinase activityPotential mechanisms