2023
The effect of single dose albendazole (400 mg) treatment on the human gut microbiome of hookworm-infected Ghanaian individuals
Appiah-Twum F, Akorli J, Okyere L, Sagoe K, Osabutey D, Cappello M, Wilson M. The effect of single dose albendazole (400 mg) treatment on the human gut microbiome of hookworm-infected Ghanaian individuals. Scientific Reports 2023, 13: 11302. PMID: 37438457, PMCID: PMC10338455, DOI: 10.1038/s41598-023-38376-3.Peer-Reviewed Original ResearchConceptsHookworm infectionAlbendazole treatmentMicrobiota compositionStool samplesGut microbiomeGut microbiome dysbiosisInfection cure rateKintampo North MunicipalityPre-treatment statePotential microbial biomarkersAdjunct treatmentAnthelminthic therapySingle doseCure rateMicrobiome dysbiosisTreatment outcomesGut homeostasisPharmacological responseProbiotic supplementationGut microbiotaUninfected individualsCommensal bacteriaInfected individualsTherapy outcomeHuman gut microbiome
2021
Effect of hookworm infection and anthelmintic treatment on naturally acquired antibody responses against the GMZ2 malaria vaccine candidate and constituent antigens
Amoani B, Gyan B, Sakyi SA, Abu EK, Nuvor SV, Barnes P, Sarkodie-Addo T, Ahenkorah B, Sewor C, Dwomoh D, Theisen M, Cappello M, Wilson MD, Adu B. Effect of hookworm infection and anthelmintic treatment on naturally acquired antibody responses against the GMZ2 malaria vaccine candidate and constituent antigens. BMC Infectious Diseases 2021, 21: 332. PMID: 33832450, PMCID: PMC8028774, DOI: 10.1186/s12879-021-06027-5.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAlbendazoleAnthelminticsAntibodies, ProtozoanAntigens, ProtozoanCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesFemaleHookworm InfectionsHumansImmunoglobulin GLongitudinal StudiesMalaria VaccinesMalaria, FalciparumMaleMiddle AgedParasitemiaProtozoan ProteinsYoung AdultConceptsMerozoite surface protein 3Antibody responseHookworm infectionMalaria vaccine candidateConstituent antigensP. falciparumGLURP-R0IgG3 levelsVaccine candidatesLongitudinal cross-sectional studyHigher IgG3 levelsUninfected endemic controlsP. falciparum infectionPlasmodium falciparum merozoite surface protein 3Levels of IgG1Kato-Katz methodCross-sectional studyHigher antibody responseMalaria vaccine efficacyKintampo North MunicipalityAnthelmintic treatmentHookworm treatmentMalaria parasitaemiaAlbendazole treatmentEndemic controls
2018
Albendazole Treatment Improves Work Capacity in Women Smallholder Farmers Infected with Hookworm: A Double-Blind Randomized Control Trial.
Salmon M, Salmon C, Masoda M, Salumu JM, Bozzi C, Nieburg P, Harrison LM, Humphries D, Abaca Uvon N, Wendel SK, Trout C, Cappello M. Albendazole Treatment Improves Work Capacity in Women Smallholder Farmers Infected with Hookworm: A Double-Blind Randomized Control Trial. American Journal Of Tropical Medicine And Hygiene 2018, 98: 1419-1426. PMID: 29611504, PMCID: PMC5953358, DOI: 10.4269/ajtmh.17-0403.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlbendazoleAnthelminticsDouble-Blind MethodFarmersFemaleHeart RateHookworm InfectionsHumansConceptsWork capacityRandomized Effectiveness TrialSoil-transmitted helminthsHealth of womenStep testPlacebo groupAlbendazole treatmentPrimary outcomeHookworm infectionStep test resultsEffectiveness trialNonsignificant decreaseHeart rateControl trialTreatment groupsIntestinal parasitesPulse rateHookwormTrialsRisk benefitDrug distributionWomenTreatmentAlbendazoleMinutes
2016
Effectiveness of Albendazole for Hookworm Varies Widely by Community and Correlates with Nutritional Factors: A Cross-Sectional Study of School-Age Children in Ghana.
Humphries D, Nguyen S, Kumar S, Quagraine JE, Otchere J, Harrison LM, Wilson M, Cappello M. Effectiveness of Albendazole for Hookworm Varies Widely by Community and Correlates with Nutritional Factors: A Cross-Sectional Study of School-Age Children in Ghana. American Journal Of Tropical Medicine And Hygiene 2016, 96: 347-354. PMID: 27895280, PMCID: PMC5303035, DOI: 10.4269/ajtmh.16-0682.Peer-Reviewed Original ResearchConceptsEgg reduction rateCross-sectional studyMass drug administrationSchool-aged childrenEffectiveness of albendazoleCure rateDrug AdministrationMid-upper arm circumferenceSoil-transmitted helminth infectionsHost factorsNutritional factorsSingle-dose albendazoleOverall cure rateBlood hemoglobin levelsKintampo North MunicipalitySignificant community-level variationIndividual host factorsWorld Health OrganizationCommon STHHemoglobin levelsArm circumferenceHookworm infectionHelminth infectionsDeworming programsHookworm prevalence
2013
Hookworm Infection among School Age Children in Kintampo North Municipality, Ghana: Nutritional Risk Factors and Response to Albendazole Treatment
Humphries D, Simms BT, Davey D, Otchere J, Quagraine J, Terryah S, Newton S, Berg E, Harrison LM, Boakye D, Wilson M, Cappello M. Hookworm Infection among School Age Children in Kintampo North Municipality, Ghana: Nutritional Risk Factors and Response to Albendazole Treatment. American Journal Of Tropical Medicine And Hygiene 2013, 89: 540-548. PMID: 23836564, PMCID: PMC3771297, DOI: 10.4269/ajtmh.12-0605.Peer-Reviewed Original ResearchConceptsKintampo North MunicipalityHookworm infectionCure rateSchool-aged childrenModest cure ratesSingle-dose albendazoleNutritional risk factorsLevels of antibodiesYears of ageAge childrenMalaria parasitemiaAlbendazole treatmentRisk factorsChildren 6InfectionInfection statusHealth careSignificant predictorsAnimal foodsHookwormAlbendazoleFurther investigationAgeChildrenLow consumption
2011
Epidemiology of Hookworm Infection in Kintampo North Municipality, Ghana: Patterns of Malaria Coinfection, Anemia, and Albendazole Treatment Failure
Humphries D, Mosites E, Otchere J, Twum WA, Woo L, Jones-Sanpei H, Harrison LM, Bungiro RD, Benham-Pyle B, Bimi L, Edoh D, Bosompem K, Wilson M, Cappello M. Epidemiology of Hookworm Infection in Kintampo North Municipality, Ghana: Patterns of Malaria Coinfection, Anemia, and Albendazole Treatment Failure. American Journal Of Tropical Medicine And Hygiene 2011, 84: 792-800. PMID: 21540391, PMCID: PMC3083749, DOI: 10.4269/ajtmh.2011.11-0003.Peer-Reviewed Original ResearchConceptsPoor nutritional statusHookworm infectionRisk factorsNutritional statusOverall egg reduction rateSerum immunoglobulin G (IgG) reactivitiesCross-sectional pilot studyEgg reduction rateImmunoglobulin G reactivityKintampo North MunicipalityAlbendazole therapyKintampo NorthMalaria coinfectionTreatment failureOverall prevalenceHigh prevalenceRepeat examinationEgg excretionSecretory antigensInfectionPilot studyCoinfectionSignificant reductionTherapyHigh rate