2014
Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes
Espitia CM, Saldarriaga OA, Travi BL, Osorio EY, Hernandez A, Band M, Patel MJ, Medina AA, Cappello M, Pekosz A, Melby PC. Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes. BMC Immunology 2014, 15: 38. PMID: 25424735, PMCID: PMC4253007, DOI: 10.1186/s12865-014-0038-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCluster AnalysisCricetinaeCytokinesDisease ProgressionDNA, ComplementaryExpressed Sequence TagsGene Expression ProfilingGene Expression RegulationGene OntologyHumansInterferon-gammaLeishmania donovaniLeishmaniasis, VisceralMesocricetusMolecular Sequence AnnotationOligonucleotide Array Sequence AnalysisPrincipal Component AnalysisRNA, MessengerSignal TransductionSpleenUp-RegulationConceptsSyrian golden hamstersVisceral leishmaniasisHamster modelGolden hamstersProgressive visceral leishmaniasisIL-4/ILIFN-γ responsesAlternative macrophage activationProgression of diseaseStudy of immunopathogenesisHamster infection modelPolarization of macrophagesImmune cell traffickingImmune response genesImmune-related genesSpleen responseImmunopathological featuresMassive splenomegalyInfected groupMacrophage activationIntracellular protozoanCell traffickingType 1Infection modelLeishmaniasis
2004
Formation of tissue factor–factor VIIa–factor Xa complex promotes cellular signaling and migration of human breast cancer cells
Jiang X, Bailly M, Panetti T, Cappello M, Konigsberg W, Bromberg M. Formation of tissue factor–factor VIIa–factor Xa complex promotes cellular signaling and migration of human breast cancer cells. Journal Of Thrombosis And Haemostasis 2004, 2: 93-101. PMID: 14717972, DOI: 10.1111/j.1538-7836.2004.00545.x.Peer-Reviewed Original ResearchConceptsHuman breast cancer cellsMAPK phosphorylationCellular signalingBreast cancer cellsCell migrationCancer cellsCell linesTF-FVIIa complex formationProtein kinase phosphorylationTumor cell migrationConcentrations of FVIIaKinase phosphorylationTranscriptase-polymerase chain reaction analysisP44/42 mitogenTissue factorPhosphorylationTransmembrane glycoproteinReverse transcriptase-polymerase chain reaction analysisProtease-activated receptor 1TF-FVIIaSpecific agonist peptideChain reaction analysisSignalingPhysiological consequencesPathway