Oxadiazole 2-oxides are toxic to the human hookworm, Ancylostoma ceylanicum, however glutathione reductase is not the primary target
Treger R, Cook A, Rai G, Maloney D, Simeonov A, Jadhav A, Thomas C, Williams D, Cappello M, Vermeire J. Oxadiazole 2-oxides are toxic to the human hookworm, Ancylostoma ceylanicum, however glutathione reductase is not the primary target. International Journal For Parasitology Drugs And Drug Resistance 2012, 2: 171-177. PMID: 22844653, PMCID: PMC3404738, DOI: 10.1016/j.ijpddr.2012.05.001.Peer-Reviewed Original ResearchAncylostoma ceylanicumVivo anthelminthic efficacyIntestinal worm burdenEffective drug therapyGlutathione reductasePrimary targetOral treatmentSevere anemiaDrug therapyHookworm infectionHookworm Ancylostoma ceylanicumAntischistosomal compoundsHamster modelNovel chemotherapyTrematode parasite Schistosoma mansoniWorm burdenGrowth delayHookworm diseaseParasite Schistosoma mansoniEx vivoParasitic diseasesParasite deathA. ceylanicumSchistosoma mansoniWeight gain