2016
Hamsters vaccinated with Ace-mep-7 DNA vaccine produced protective immunity against Ancylostoma ceylanicum infection
Wiśniewski M, Jaros S, Bąska P, Cappello M, Długosz E, Wędrychowicz H. Hamsters vaccinated with Ace-mep-7 DNA vaccine produced protective immunity against Ancylostoma ceylanicum infection. Experimental Parasitology 2016, 163: 1-7. PMID: 26795262, DOI: 10.1016/j.exppara.2016.01.006.Peer-Reviewed Original ResearchConceptsA. ceylanicum infectionAncylostoma ceylanicum infectionHookworm speciesWorm burden reductionsSyrian golden hamstersProtective immunityDNA vaccineGut mucosaGastrointestinal tractIntestinal nematodesGolden hamstersBurden reductionAdult wormsHemoglobin digestionEgg countsImmunizationVaccineInfectionHamstersMetalloproteasesMucosaHookwormBloodTractImmunity
2013
Ancylostoma ceylanicum metalloprotease 6 DNA vaccination induces partial protection against hookworm challenge infection
Wiśniewski M, Jaros S, Bąska P, Cappello M, Wędrychowicz H. Ancylostoma ceylanicum metalloprotease 6 DNA vaccination induces partial protection against hookworm challenge infection. Acta Parasitologica 2013, 58: 376-383. PMID: 23990436, DOI: 10.2478/s11686-013-0151-9.Peer-Reviewed Original ResearchConceptsChallenge infectionAnthelminthic drug resistanceEffective human vaccineWorm burden reductionsGroups of hamstersIron deficiency anemiaCDNA vaccineTriple immunizationInfected childrenDeficiency anemiaDNA vaccineHookworm infectionDNA vaccinationHuman vaccinesAnimal modelsNumerous antigensVaccine developmentGrowth retardationIntestinal nematodesDrug resistanceVaccineBurden reductionPartial protectionInfectionHemoglobin digestion
2004
Hookworm infection: new developments and prospects for control
Bungiro R, Cappello M. Hookworm infection: new developments and prospects for control. Current Opinion In Infectious Diseases 2004, 17: 421-426. PMID: 15353961, DOI: 10.1097/00001432-200410000-00006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHookworm infectionHookworm diseaseEffective global controlPathological immune responsesMajor health burdenParasite virulence factorsNew chemotherapeutic agentsDevelopment of vaccinesHookworm anaemiaImmunoepidemiological studiesMass chemotherapyHealth burdenImmune responseMolecular pathogenesisGrowth delayChemotherapeutic agentsInfectionVaccineSocioeconomic statusDiseaseVirulence factorsGlobal healthBenzimidazole anthelminthicsPathogenesisAnthelminthic resistance
1996
Molecular Approaches to Vaccinating against Hookworm Disease
Hotez P, Hawdon J, Cappello M, Jones B, Ghosh K, Volvovitz F, Shu-Hua X. Molecular Approaches to Vaccinating against Hookworm Disease. Pediatric Research 1996, 40: 515-521. PMID: 8888276, DOI: 10.1203/00006450-199610000-00001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLarval antigensVaccine antigensInfective hookworm larvaeProtective immunityHookworm infectionAdjuvant formulationsDrug chemotherapyAlternative vaccinesVaccine routeLive vaccineGenetic immunizationVaccine developmentHookworm larvaeHookworm diseaseParasitic diseasesAntigenPhase IVaccineAncylostoma caninumProtein 1ImmunizationTarget populationAcceptable approachDiseaseASP-2