2014
Application of a Poisson distribution quality control measure to the analysis of two human hookworm drug treatment studies in Ghana
Kotze AC, Dobson RJ, Humphries D, Wilson M, Cappello M. Application of a Poisson distribution quality control measure to the analysis of two human hookworm drug treatment studies in Ghana. International Journal For Parasitology Drugs And Drug Resistance 2014, 4: 64-70. PMID: 24596670, PMCID: PMC3940077, DOI: 10.1016/j.ijpddr.2014.01.001.Peer-Reviewed Original ResearchDrug treatmentFaecal egg count reduction testDrug efficacyPre-treatment samplesDrug treatment studiesOverall drug efficacyStudy subjectsSignificant prevalenceEgg excretionPoisson distribution analysisTreatment studiesEfficacySignificant increaseEgg count reduction testSubjectsTreatmentControl measuresSuch subjectsReduction testStoolCasesPoisson distribution methodExcretionPrevalenceQuality control measures
2012
The promise and pitfalls of mass drug administration to control intestinal helminth infections
Humphries D, Nguyen S, Boakye D, Wilson M, Cappello M. The promise and pitfalls of mass drug administration to control intestinal helminth infections. Current Opinion In Infectious Diseases 2012, 25: 584-589. PMID: 22903231, DOI: 10.1097/qco.0b013e328357e4cf.Peer-Reviewed Original ResearchConceptsMass drug administrationIntestinal helminth infectionsHelminth infectionsDrug AdministrationSoil-transmitted nematode infectionsIntensity of schistosomiasisHigh-risk groupResource-limited settingsLong-term controlSignificant morbidityPregnant womenLong-term benefitsNew drug developmentIntensity of infectionIntestinal helminthsEndemic areasConsistent benefitInfectionChemotherapeutic interventionCertain populationsDrug developmentBenzimidazole anthelminthicsIntensive monitoringPrevalenceAdministration