2008
Orthologs of macrophage migration inhibitory factor from parasitic nematodes
Vermeire JJ, Cho Y, Lolis E, Bucala R, Cappello M. Orthologs of macrophage migration inhibitory factor from parasitic nematodes. Trends In Parasitology 2008, 24: 355-363. PMID: 18603473, PMCID: PMC3615561, DOI: 10.1016/j.pt.2008.04.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMacrophage migration inhibitory factorParasitic nematodesMigration inhibitory factorHost-parasite interfaceSpecies-specific activityDevelopmental biologyThree-dimensional structureMammalian hostsInhibitory factorHost cellular immune responseParasite survivalChronic helminth infectionsVaccine-based strategiesCellular immune responsesOrthologsMIF moleculeParasite moleculesNematodesHost cytokinesImmune responseHelminth infectionsDisease controlIdeal targetRecent progressMolecules
2006
A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum
Cappello M, Bungiro RD, Harrison LM, Bischof LJ, Griffitts JS, Barrows BD, Aroian RV. A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 15154-15159. PMID: 17005719, PMCID: PMC1622792, DOI: 10.1073/pnas.0607002103.Peer-Reviewed Original ResearchConceptsCry proteinsCrystal proteinsSoil bacterium Bacillus thuringiensisBacterium Bacillus thuringiensisBacillus thuringiensis crystal proteinsBt Cry proteinsVivo anthelminthic activityFree-living nematodesA. ceylanicumLarval development assaysAdult A. ceylanicumGastrointestinal nematodesBacillus thuringiensisParasitic nematodesNematode parasitesVeterinary useCry5BAncylostoma ceylanicumNematodesDevelopment assaysEgg excretionAdult female wormsHuman diseasesWorm burdenPermissive host
2000
A Broad Spectrum Kunitz Type Serine Protease Inhibitor Secreted by the Hookworm Ancylostoma ceylanicum *
Milstone A, Harrison L, Bungiro R, Kuzmic̆ P, Cappello M. A Broad Spectrum Kunitz Type Serine Protease Inhibitor Secreted by the Hookworm Ancylostoma ceylanicum *. Journal Of Biological Chemistry 2000, 275: 29391-29399. PMID: 10893410, DOI: 10.1074/jbc.m002715200.Peer-Reviewed Original ResearchConceptsKunitz-type serine protease inhibitorType serine protease inhibitorSerine protease inhibitorSecretory signal sequenceBlood-feeding hookwormsPET-28a plasmidSoluble protein extractsTight binding inhibitorMature proteinCDNA correspondingSignal sequenceParasitic nematodesInfective third-stage larvaeProtease inhibitorsRecombinant proteinsParasite survivalMolecular mechanismsMolecular massProtein extractsEscherichia coliExcretory/secretory productsSerine proteasesThird-stage larvaeAdult A. ceylanicumIron deficiency anemia