2005
Discovery and pre-clinical development of antithrombotics from hematophagous invertebrates.
Ledizet M, Harrison LM, Koskia RA, Cappello M. Discovery and pre-clinical development of antithrombotics from hematophagous invertebrates. Cardiovascular & Hematological Agents In Medicinal Chemistry 2005, 3: 1-10. PMID: 15638739, DOI: 10.2174/1568016052773315.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNumerous invertebrate speciesHematophagous invertebratesInvertebrate speciesSpecific inhibitorUnique specificityInvertebratesFunctional strategiesCritical roleImpressive arrayActivation of thrombosisUseful therapeutic agentPre-clinical developmentNatural productsInhibitorsPlatelet inhibitorsHeart diseaseHuman illnessPlatelet functionClinical developmentSpeciesTherapeutic agentsAntithromboticsParasitesBloodmealThrombosis
1988
Induction of resistance to Schistosoma mansoni by immunization with subfractions of worms.
Knopf P, Goldberg M, Grossi C, Cappello M, Coulter S. Induction of resistance to Schistosoma mansoni by immunization with subfractions of worms. American Journal Of Tropical Medicine And Hygiene 1988, 38: 515-28. PMID: 3152780, DOI: 10.4269/ajtmh.1988.38.515.Peer-Reviewed Original ResearchConceptsInfection 3 weeksSchistosoma mansoni infectionExposure of ratsInduction of resistanceGlutaraldehyde-fixed parasitesLive infectionMansoni infectionBooster injectionChallenge infectionNaive ratsImmunization protocolDifferent adjuvantsLow dosesDose sizeRatsSchistosoma mansoniPartial protectionInfectionMiceInjectionWeeksInductionSubfractionsParasitesBuffered saline