2008
Orthologs of macrophage migration inhibitory factor from parasitic nematodes
Vermeire JJ, Cho Y, Lolis E, Bucala R, Cappello M. Orthologs of macrophage migration inhibitory factor from parasitic nematodes. Trends In Parasitology 2008, 24: 355-363. PMID: 18603473, PMCID: PMC3615561, DOI: 10.1016/j.pt.2008.04.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMacrophage migration inhibitory factorParasitic nematodesMigration inhibitory factorHost-parasite interfaceSpecies-specific activityDevelopmental biologyThree-dimensional structureMammalian hostsInhibitory factorHost cellular immune responseParasite survivalChronic helminth infectionsVaccine-based strategiesCellular immune responsesOrthologsMIF moleculeParasite moleculesNematodesHost cytokinesImmune responseHelminth infectionsDisease controlIdeal targetRecent progressMolecules
2007
Structural and Functional Characterization of a Secreted Hookworm Macrophage Migration Inhibitory Factor (MIF) That Interacts with the Human MIF Receptor CD74*
Cho Y, Jones BF, Vermeire JJ, Leng L, DiFedele L, Harrison LM, Xiong H, Kwong YK, Chen Y, Bucala R, Lolis E, Cappello M. Structural and Functional Characterization of a Secreted Hookworm Macrophage Migration Inhibitory Factor (MIF) That Interacts with the Human MIF Receptor CD74*. Journal Of Biological Chemistry 2007, 282: 23447-23456. PMID: 17567581, PMCID: PMC3707627, DOI: 10.1074/jbc.m702950200.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAncylostomaAnimalsAntigens, Differentiation, B-LymphocyteCricetinaeCytokinesHistocompatibility Antigens Class IIHumansIntestinal MucosaMacrophage Migration-Inhibitory FactorsMesocricetusMolecular Sequence DataProtein BindingRabbitsRecombinant ProteinsSequence Homology, Amino AcidConceptsMacrophage migration inhibitory factorMIF receptor CD74Migration inhibitory factorReceptor CD74Inhibitory factorHost immune responseHuman macrophage migration inhibitory factorMIF proteinHookworm Ancylostoma ceylanicumImmune responseDisease pathogenesisHuman cytokinesMacrophage migrationAncylostoma ceylanicumMajor causeWorm survivalParasite survivalISO-1Significant differencesTautomerase activityHookworm proteinsCytokinesCD74HookwormRelative bioactivity
2000
A Broad Spectrum Kunitz Type Serine Protease Inhibitor Secreted by the Hookworm Ancylostoma ceylanicum *
Milstone A, Harrison L, Bungiro R, Kuzmic̆ P, Cappello M. A Broad Spectrum Kunitz Type Serine Protease Inhibitor Secreted by the Hookworm Ancylostoma ceylanicum *. Journal Of Biological Chemistry 2000, 275: 29391-29399. PMID: 10893410, DOI: 10.1074/jbc.m002715200.Peer-Reviewed Original ResearchConceptsKunitz-type serine protease inhibitorType serine protease inhibitorSerine protease inhibitorSecretory signal sequenceBlood-feeding hookwormsPET-28a plasmidSoluble protein extractsTight binding inhibitorMature proteinCDNA correspondingSignal sequenceParasitic nematodesInfective third-stage larvaeProtease inhibitorsRecombinant proteinsParasite survivalMolecular mechanismsMolecular massProtein extractsEscherichia coliExcretory/secretory productsSerine proteasesThird-stage larvaeAdult A. ceylanicumIron deficiency anemia