2004
Hookworm infection: molecular mechanisms of disease and targets for control
Jones B, Cappello M. Hookworm infection: molecular mechanisms of disease and targets for control. Drug Discovery Today Disease Mechanisms 2004, 1: 217-222. DOI: 10.1016/j.ddmec.2004.10.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHookworm anaemiaSmall intestineMajor global health problemStage of diseaseGlobal health problemProtein-energy malnutritionVirulence factorsMolecular mechanismsPregnant womenSevere anemiaVaccine strategiesPlatelet inhibitorsPancreatic digestive enzymesHealth burdenEnergy malnutritionHost small intestineHealth problemsGrowth delayAnemiaHookworm diseaseIntestinal nematodesDisease controlChild mortalityMount Sinai SchoolPotential target
2000
A Broad Spectrum Kunitz Type Serine Protease Inhibitor Secreted by the Hookworm Ancylostoma ceylanicum *
Milstone A, Harrison L, Bungiro R, Kuzmic̆ P, Cappello M. A Broad Spectrum Kunitz Type Serine Protease Inhibitor Secreted by the Hookworm Ancylostoma ceylanicum *. Journal Of Biological Chemistry 2000, 275: 29391-29399. PMID: 10893410, DOI: 10.1074/jbc.m002715200.Peer-Reviewed Original ResearchConceptsKunitz-type serine protease inhibitorType serine protease inhibitorSerine protease inhibitorSecretory signal sequenceBlood-feeding hookwormsPET-28a plasmidSoluble protein extractsTight binding inhibitorMature proteinCDNA correspondingSignal sequenceParasitic nematodesInfective third-stage larvaeProtease inhibitorsRecombinant proteinsParasite survivalMolecular mechanismsMolecular massProtein extractsEscherichia coliExcretory/secretory productsSerine proteasesThird-stage larvaeAdult A. ceylanicumIron deficiency anemia