2021
Effect of hookworm infection and anthelmintic treatment on naturally acquired antibody responses against the GMZ2 malaria vaccine candidate and constituent antigens
Amoani B, Gyan B, Sakyi SA, Abu EK, Nuvor SV, Barnes P, Sarkodie-Addo T, Ahenkorah B, Sewor C, Dwomoh D, Theisen M, Cappello M, Wilson MD, Adu B. Effect of hookworm infection and anthelmintic treatment on naturally acquired antibody responses against the GMZ2 malaria vaccine candidate and constituent antigens. BMC Infectious Diseases 2021, 21: 332. PMID: 33832450, PMCID: PMC8028774, DOI: 10.1186/s12879-021-06027-5.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAlbendazoleAnthelminticsAntibodies, ProtozoanAntigens, ProtozoanCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesFemaleHookworm InfectionsHumansImmunoglobulin GLongitudinal StudiesMalaria VaccinesMalaria, FalciparumMaleMiddle AgedParasitemiaProtozoan ProteinsYoung AdultConceptsMerozoite surface protein 3Antibody responseHookworm infectionMalaria vaccine candidateConstituent antigensP. falciparumGLURP-R0IgG3 levelsVaccine candidatesLongitudinal cross-sectional studyHigher IgG3 levelsUninfected endemic controlsP. falciparum infectionPlasmodium falciparum merozoite surface protein 3Levels of IgG1Kato-Katz methodCross-sectional studyHigher antibody responseMalaria vaccine efficacyKintampo North MunicipalityAnthelmintic treatmentHookworm treatmentMalaria parasitaemiaAlbendazole treatmentEndemic controls
2019
Cytokine profiles of Necator americanus and Plasmodium falciparum co-infected patients in rural Ghana
Amoani B, Adu B, Frempong MT, Sarkodie-Addo T, Nuvor S, Abu EK, Harrison LM, Cappello M, Gyan B, Wilson MD. Cytokine profiles of Necator americanus and Plasmodium falciparum co-infected patients in rural Ghana. Cytokine X 2019, 1: 100014. PMID: 33604551, PMCID: PMC7885886, DOI: 10.1016/j.cytox.2019.100014.Peer-Reviewed Original ResearchCo-infected individualsCytokine profileStool samplesCCL11 levelsMalaria parasitaemiaBlood parasitemia levelsCo-infected patientsIL-10 levelsIL-5 levelsTNF-α levelsCytokines interleukin-5Kato-Katz methodCross-sectional studyHuman immune responseTumor necrosis factorKintampo North MunicipalityPresence of hookwormEffect of hookwormRural GhanaEffector mediatorsHookworm intensityCytokine levelsAlbendazole treatmentSerum levelsCytokine responses