2008
Role for Nitric Oxide in Hookworm-Associated Immune Suppression
Dondji B, Bungiro RD, Harrison LM, Vermeire JJ, Bifulco C, McMahon-Pratt D, Cappello M. Role for Nitric Oxide in Hookworm-Associated Immune Suppression. Infection And Immunity 2008, 76: 2560-2567. PMID: 18347036, PMCID: PMC2423093, DOI: 10.1128/iai.00094-08.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsHookworm infectionNitric oxideInfected animalsMesenteric lymph node cellsHost cellular immune responseCellular immune responsesLymph node cellsProliferative capacityT cell preparationsSurface immunoglobulin GParasite-induced immunosuppressionResource-poor countriesHookworm antigensMLN cellsLymphocyte subpopulationsPositive lymphocytesCellular immunityImmune suppressionLymphocyte proliferationNode cellsFluorescence-activated cell sortingInfected hamstersImmune responseAnimal studies
2006
Dietary Iron Content Mediates Hookworm Pathogenesis In Vivo
Held MR, Bungiro RD, Harrison LM, Hamza I, Cappello M. Dietary Iron Content Mediates Hookworm Pathogenesis In Vivo. Infection And Immunity 2006, 74: 289-295. PMID: 16368983, PMCID: PMC1346670, DOI: 10.1128/iai.74.1.289-295.2006.Peer-Reviewed Original ResearchConceptsDay 20 postinfectionGrowth delayIron-restricted dietHigh-iron dietIntestinal worm burdenDietary iron restrictionIron deficiency anemiaBlood hemoglobin levelsDietary iron contentGreater weight lossSignificant growth delayHemoglobin levelsDeficiency anemiaHookworm infectionDiet groupHamster modelSevere diseaseStandard dietUninfected controlsHemoglobin concentrationUninfected animalsWorm burdenDay 10Infected animalsHookworm disease