2022
Plasmodium falciparum coinfection is associated with improved IgE and IgG3 response against hookworm antigens
Sakyi SA, Wilson MD, Adu B, Opoku S, Brewoo A, Larbi A, Baafour EK, Tchum SK, Saahene RO, Aniagyei W, Sewor C, Courtin D, Cappello M, Gyan B, Amoani B. Plasmodium falciparum coinfection is associated with improved IgE and IgG3 response against hookworm antigens. Health Science Reports 2022, 5: e672. PMID: 35734341, PMCID: PMC9195015, DOI: 10.1002/hsr2.672.Peer-Reviewed Original ResearchL3 stage larvaeAlbendazole treatmentHookworm infectionImmune responseNonendemic controlsPlasmodium falciparum coinfectionsIron deficiency anemiaHookworm treatmentVaccine effectivenessIgG3 responsesIgG responsesAntibody profileSingle doseDeficiency anemiaIgG3 antibodiesBlood samplesIgEProtein malnutritionControl groupVaccine developmentHigh levelsSerum samplesIgG3Stage larvaeInfection
2021
Effect of hookworm infection and anthelmintic treatment on naturally acquired antibody responses against the GMZ2 malaria vaccine candidate and constituent antigens
Amoani B, Gyan B, Sakyi SA, Abu EK, Nuvor SV, Barnes P, Sarkodie-Addo T, Ahenkorah B, Sewor C, Dwomoh D, Theisen M, Cappello M, Wilson MD, Adu B. Effect of hookworm infection and anthelmintic treatment on naturally acquired antibody responses against the GMZ2 malaria vaccine candidate and constituent antigens. BMC Infectious Diseases 2021, 21: 332. PMID: 33832450, PMCID: PMC8028774, DOI: 10.1186/s12879-021-06027-5.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAlbendazoleAnthelminticsAntibodies, ProtozoanAntigens, ProtozoanCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesFemaleHookworm InfectionsHumansImmunoglobulin GLongitudinal StudiesMalaria VaccinesMalaria, FalciparumMaleMiddle AgedParasitemiaProtozoan ProteinsYoung AdultConceptsMerozoite surface protein 3Antibody responseHookworm infectionMalaria vaccine candidateConstituent antigensP. falciparumGLURP-R0IgG3 levelsVaccine candidatesLongitudinal cross-sectional studyHigher IgG3 levelsUninfected endemic controlsP. falciparum infectionPlasmodium falciparum merozoite surface protein 3Levels of IgG1Kato-Katz methodCross-sectional studyHigher antibody responseMalaria vaccine efficacyKintampo North MunicipalityAnthelmintic treatmentHookworm treatmentMalaria parasitaemiaAlbendazole treatmentEndemic controls