2010
CD4+ T cells mediate mucosal and systemic immune responses to experimental hookworm infection
DONDJI B, SUN T, BUNGIRO RD, VERMEIRE JJ, HARRISON LM, BIFULCO C, CAPPELLO M. CD4+ T cells mediate mucosal and systemic immune responses to experimental hookworm infection. Parasite Immunology 2010, 32: 406-413. PMID: 20500671, PMCID: PMC3241967, DOI: 10.1111/j.1365-3024.2010.01204.x.Peer-Reviewed Original ResearchConceptsT cellsImmune responseHookworm infectionHost cellular immune responseExperimental hookworm infectionT-cell depletionMesenteric lymph nodesSystemic immune responsesCellular immune responsesHumoral immune responseIntestinal nematode infectionsIntestinal worm burdenResource-limited countriesHookworm antigensLymph nodesSevere anemiaIntraperitoneal injectionLymphocyte proliferationHookworm Ancylostoma ceylanicumIsotype controlDisease pathogenesisWorm burdenSyrian hamstersAncylostoma ceylanicumEffector role
2008
Role for Nitric Oxide in Hookworm-Associated Immune Suppression
Dondji B, Bungiro RD, Harrison LM, Vermeire JJ, Bifulco C, McMahon-Pratt D, Cappello M. Role for Nitric Oxide in Hookworm-Associated Immune Suppression. Infection And Immunity 2008, 76: 2560-2567. PMID: 18347036, PMCID: PMC2423093, DOI: 10.1128/iai.00094-08.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsHookworm infectionNitric oxideInfected animalsMesenteric lymph node cellsHost cellular immune responseCellular immune responsesLymph node cellsProliferative capacityT cell preparationsSurface immunoglobulin GParasite-induced immunosuppressionResource-poor countriesHookworm antigensMLN cellsLymphocyte subpopulationsPositive lymphocytesCellular immunityImmune suppressionLymphocyte proliferationNode cellsFluorescence-activated cell sortingInfected hamstersImmune responseAnimal studies
2005
Detection of excretory/secretory coproantigens in experimental hookworm infection.
Bungiro RD, Cappello M. Detection of excretory/secretory coproantigens in experimental hookworm infection. American Journal Of Tropical Medicine And Hygiene 2005, 73: 915-20. PMID: 16282303, DOI: 10.4269/ajtmh.2005.73.915.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayMolecular host-parasite interactionsFuture diagnostic methodsExcretory/secretoryFecal extractsImmunosorbent assayA. ceylanicum infectionExperimental hookworm infectionIntestinal worm burdenRabbit polyclonal IgG antibodyPolyclonal IgG antibodiesES proteinsDiagnostic methodsHookworm antigensDetectionHookworm infectionIgG antibodiesStool samplesWorm burdenDay 17Hamster serumCoproantigenFaecal eggMug/Degrees C.