2001
Molecular Characterization of Ancylostoma Inhibitors of Coagulation Factor Xa HOOKWORM ANTICOAGULANT ACTIVITY IN VITRO PREDICTS PARASITE BLOODFEEDING IN VIVO *
Harrison LM, Nerlinger A, Bungiro RD, Córdova JL, Kuzmič P, Cappello M. Molecular Characterization of Ancylostoma Inhibitors of Coagulation Factor Xa HOOKWORM ANTICOAGULANT ACTIVITY IN VITRO PREDICTS PARASITE BLOODFEEDING IN VIVO *. Journal Of Biological Chemistry 2001, 277: 6223-6229. PMID: 11741914, DOI: 10.1074/jbc.m109908200.Peer-Reviewed Original ResearchConceptsCoagulation factor XaAdult A. ceylanicumHookworm speciesHuman vaccine developmentIron deficiency anemiaAnticoagulant activityFactor Xa inhibitory activityFactor Xa activityDog hookworm Ancylostoma caninumFactor XaXa inhibitory activityMechanism of actionFirst anticoagulantGastrointestinal hemorrhageDeficiency anemiaReverse transcription-PCRSpecies of hookwormXa activityPeptide-1Vaccine developmentHookworm Ancylostoma caninumA. ceylanicumAncylostoma ceylanicumHookwormAncylostoma caninum
1996
Anticoagulant repertoire of the hookworm Ancylostoma caninum.
Stassens P, Bergum P, Gansemans Y, Jespers L, Laroche Y, Huang S, Maki S, Messens J, Lauwereys M, Cappello M, Hotez P, Lasters I, Vlasuk G. Anticoagulant repertoire of the hookworm Ancylostoma caninum. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 2149-2154. PMID: 8700900, PMCID: PMC39925, DOI: 10.1073/pnas.93.5.2149.Peer-Reviewed Original ResearchConceptsHookworm Ancylostoma caninumReactive site residuesFVIIa/TFBlood coagulation factor VIIaBlood coagulation factor XaMolecular cloningSerine protease inhibitorMammalian hostsCysteine residuesHost hemostasisSite residuesCoagulation factor VIIaHomologous regionsSequence positionsAncylostoma caninumNematode AscarisCatalytic centerBinary complexUnique mechanismCoagulation factor XaProtease inhibitorsResiduesInhibitorsTissue factorThird form