Ancylostoma Factor Xa Inhibitor: Partial Purification and Its Identification as a Major Hookworm-Derived Anticoagulant In Vitro
Cappello M, Clyne L, McPhedran P, Hotez P. Ancylostoma Factor Xa Inhibitor: Partial Purification and Its Identification as a Major Hookworm-Derived Anticoagulant In Vitro. The Journal Of Infectious Diseases 1993, 167: 1474-1477. PMID: 8501344, DOI: 10.1093/infdis/167.6.1474.Peer-Reviewed Original ResearchConceptsPotent factor Xa inhibitorsIon-exchange column chromatographyColumn chromatographyAnticoagulant activityAncylostoma hookwormsPartial thromboplastin timePeptide substratesColumn fractionsProthrombin timeChromogenic peptide substratesPartial purificationAnti-Xa activityFactor Xa inhibitorsChromatographyTime assaysPurificationSoluble protein extractsThromboplastin timeXa inhibitors