2011
Twenty-First Century Progress Toward the Global Control of Human Hookworm Infection
Bungiro R, Cappello M. Twenty-First Century Progress Toward the Global Control of Human Hookworm Infection. Current Infectious Disease Reports 2011, 13: 210. PMID: 21462001, DOI: 10.1007/s11908-011-0182-z.Peer-Reviewed Original ResearchHuman hookworm infectionHost immune responseCandidate vaccine antigensHigher infection rateExcretory/secretory proteinsImmunoepidemiological studiesTreatment failureHookworm infectionMass chemotherapyImmune responseAnimal modelsParasitic infectionsVaccine antigensMolecular pathogenesisInfection rateHookworm diseaseReduced efficacyProtease inhibitorsHookwormInfectionSaharan AfricaRecent studiesContinued useSecretory proteinsAsthma
2010
AV411 (Ibudilast) and AV1013 are non-competitive inhibitors of macrophage migration inhibitory factor: a novel induced-fit allosteric inhibition mechanism (133.11)
Cho Y, Crichlow G, Vermeire J, Leng L, Du X, Hodsdon M, Bucala R, Cappello M, Gross M, Gaeta F, Johnson K, Lolis E. AV411 (Ibudilast) and AV1013 are non-competitive inhibitors of macrophage migration inhibitory factor: a novel induced-fit allosteric inhibition mechanism (133.11). The Journal Of Immunology 2010, 184: 133.11-133.11. DOI: 10.4049/jimmunol.184.supp.133.11.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorMigration inhibitory factorInhibitory factorPro-inflammatory proteinsAnti-inflammatory activityAnti-inflammatory drugsNon-selective inhibitorPDE inhibitor rolipramNeuropathic painOpioid withdrawalBronchial asthmaOcular indicationsGlial cellsNon-competitive inhibitorPossible therapeuticsInhibitor rolipramChemotactic functionAV411Tautomerase activityInhibitorsAllosteric binding siteIsobutylmethylxanthineTreatmentAsthmaPain