2001
Ancylostoma caninum anticoagulant peptide-5: immunolocalization and in vitro neutralization of a major hookworm anti-thrombotic
Harrison L, Córdova J, Cappello M. Ancylostoma caninum anticoagulant peptide-5: immunolocalization and in vitro neutralization of a major hookworm anti-thrombotic. Molecular And Biochemical Parasitology 2001, 115: 101-107. PMID: 11377744, DOI: 10.1016/s0166-6851(01)00276-6.Peer-Reviewed Original ResearchConceptsPolyclonal IgGAnticoagulant activityFuture immunization strategiesGastrointestinal blood lossIron deficiency anemiaPartial thromboplastin timeFactor Xa activityHuman coagulation factor XaBlood lossDeficiency anemiaHookworm infectionThromboplastin timeXa activityAmphidial glandsAdult Ancylostoma caninum hookwormsCoagulation factor XaAdult hookwormsImmunization strategiesA. ceylanicumIgGMajor causeHookwormSerine protease inhibitorAdult wormsViable target
1999
The Hookworm Platelet Inhibitor: Functional Blockade of Integrins GPIIb/IIIa (αIIbβ3) and GPIa/IIa (α2β1) Inhibits Platelet Aggregation and Adhesion In Vitro
Chadderdon R, Cappello M. The Hookworm Platelet Inhibitor: Functional Blockade of Integrins GPIIb/IIIa (αIIbβ3) and GPIa/IIa (α2β1) Inhibits Platelet Aggregation and Adhesion In Vitro. The Journal Of Infectious Diseases 1999, 179: 1235-1241. PMID: 10191228, DOI: 10.1086/314724.Peer-Reviewed Original ResearchConceptsIntegrin GPIIb/IIIaPlatelet inhibitorsSoluble protein extractsGPIIb/IIIaPlatelet aggregationMolecular massProtein extractsIron deficiency anemiaGPIa/IIaInhibitory monoclonal antibodiesVariety of agonistsAnti-platelet activityAdult Ancylostoma caninum hookwormsInhibits platelet aggregationPlatelet receptorsDeficiency anemiaFunctional blockadeSpecific blockadeBiologic roleSize exclusion chromatographyIntestinal nematodesSecretory productsMonoclonal antibodiesInhibitorsAdult worms