Featured Publications
Comparative efficacy, tolerability, and acceptability of pharmacological interventions for the treatment of children, adolescents, and young adults with Tourette's syndrome: a systematic review and network meta-analysis
Farhat L, Behling E, Landeros-Weisenberger A, Levine J, Macul Ferreira de Barros P, Wang Z, Bloch M. Comparative efficacy, tolerability, and acceptability of pharmacological interventions for the treatment of children, adolescents, and young adults with Tourette's syndrome: a systematic review and network meta-analysis. The Lancet Child & Adolescent Health 2022, 7: 112-126. PMID: 36528030, DOI: 10.1016/s2352-4642(22)00316-9.Peer-Reviewed Original ResearchConceptsSecond-generation antipsychotic drugsMedication categoriesAntipsychotic drugsModerate certaintyIndividual medicationsTourette syndromePharmacological interventionsLow certaintyWHO International Clinical Trials Registry PlatformInternational Clinical Trials Registry PlatformSystematic reviewClinical Trials Registry PlatformChoice of medicationCochrane Central RegisterNetwork meta-analysis frameworkTrials Registry PlatformRandom-effects networkTerms of tolerabilityCertainty of evidenceClinical practice guidelinesComorbid attention deficit hyperactivity disorderStandardised mean differenceTreatment of childrenAttention deficit hyperactivity disorderWeb of Science
2019
The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects
Blanco‐Vieira T, Santos M, Ferrão YA, Torres AR, Miguel EC, Bloch MH, Leckman JF, do Rosario MC. The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects. Depression And Anxiety 2019, 36: 533-542. PMID: 30990937, DOI: 10.1002/da.22898.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderAdult OCD patientsObsessive-compulsive disorderDeficit hyperactivity disorderOCD patientsClinical characteristicsExact testFeatures of ADHDHyperactivity disorderSubgroup of patientsAdult obsessive-compulsive disorderComorbid attention deficit hyperactivity disorderSpecific clinical featuresCross-sectional studyObsessive-compulsive disorder (OCD) subjectsLogistic regression analysisFisher's exact testBrazilian Research ConsortiumMann-Whitney testAdult patientsRheumatic feverDevelopment of interventionsClinical featuresObsessive-compulsive spectrum disordersLifetime prevalence
2018
Supplementation with polyunsaturated fatty acids (PUFAs) in the management of attention deficit hyperactivity disorder (ADHD)
Banaschewski T, Belsham B, Bloch MH, Ferrin M, Johnson M, Kustow J, Robinson S, Zuddas A. Supplementation with polyunsaturated fatty acids (PUFAs) in the management of attention deficit hyperactivity disorder (ADHD). Nutrition And Health 2018, 24: 279-284. PMID: 29921155, PMCID: PMC6291899, DOI: 10.1177/0260106018772170.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderPUFA supplementationDeficit hyperactivity disorderManagement of ADHDFurther high-quality researchHyperactivity disorderPossible side effectsSmall beneficial effectRobust evidence baseChild attention-deficit hyperactivity disorderFatty acidsFrontline treatmentHigh-quality researchCurrent evidenceSide effectsPsychosocial interventionsTreatment approachesPanel consensusPatientsBeneficial effectsEvidence baseSupplementationInternational expertsDisordersAdults
2014
Clinical features of Tourette syndrome and tic disorders
Leckman JF, King RA, Bloch MH. Clinical features of Tourette syndrome and tic disorders. Journal Of Obsessive-Compulsive And Related Disorders 2014, 3: 372-379. PMID: 30197854, PMCID: PMC6124690, DOI: 10.1016/j.jocrd.2014.03.004.Peer-Reviewed Original ResearchTourette syndromeTic disordersLong-term clinical courseLong-term outcomesAge 10 yearsAttention deficit hyperactivity disorderCo-occurring conditionsClinical courseClinical featuresObsessive-compulsive disorderTic symptomsVisual-motor integrationVocal ticsPsychosocial stressMost childrenCourse of monthsLiterature searchRelevant articlesMotor integrationStereotyped movementsHyperactivity disorderEarly adulthoodDisordersNeurodevelopmental disordersSensory stimuli
2012
Clinical assessment of Tourette syndrome and tic disorders
Cohen SC, Leckman JF, Bloch MH. Clinical assessment of Tourette syndrome and tic disorders. Neuroscience & Biobehavioral Reviews 2012, 37: 997-1007. PMID: 23206664, PMCID: PMC3674220, DOI: 10.1016/j.neubiorev.2012.11.013.Peer-Reviewed Original ResearchConceptsTourette syndromeAttention deficit hyperactivity disorderObsessive-compulsive disorderTreatment of TSImpaired sensorimotor gatingPercent of childrenImpulse control disordersDeficit hyperactivity disorderSomatic hypersensitivityTic symptomsPhonic ticsPurposeless movementsTic disordersClinical assessmentSensorimotor gatingControl disordersProper diagnosisMuscle groupsPremonitory urgesNeuropsychiatric disordersHyperactivity disorderDisordersAppropriate evaluationSyndromeSensory phenomena
2006
Tourette Syndrome: The Self Under Siege
Leckman JF, Bloch MH, Scahill L, King RA. Tourette Syndrome: The Self Under Siege. Journal Of Child Neurology 2006, 21: 642-649. PMID: 16970864, DOI: 10.1177/08830738060210081001.Peer-Reviewed Original ResearchConceptsTourette syndromeAttention deficit hyperactivity disorderSensorimotor gatingSimple motor ticsYears of ageAge 10 yearsPostmortem brain studiesVivo brain imagingObsessive-compulsive disorderPrepubertal onsetVisual-motor integrationElectrophysiologic recordingsMotor ticsVocal ticsTic severityFine motorMost childrenNatural historySyndromeBehavioral treatmentMotor responseCourse of monthsNeural circuitryMotor integrationStereotyped movements