2018
Feline calicivirus- and murine norovirus-induced COX-2/PGE2 signaling pathway has proviral effects
Alfajaro M, Cho E, Park J, Kim J, Soliman M, Baek Y, Kang M, Park S, Cho K. Feline calicivirus- and murine norovirus-induced COX-2/PGE2 signaling pathway has proviral effects. PLOS ONE 2018, 13: e0200726. PMID: 30021004, PMCID: PMC6051663, DOI: 10.1371/journal.pone.0200726.Peer-Reviewed Original ResearchConceptsCOX-2/COX-1/Production of PGE2COX-2 enzymePharmacological inhibitorsProviral effectCOX-1COX-2/PGE2Potential therapeutic candidateAddition of PGE2Small interfering RNAsSame virus familyReplication of virusesInfection of cellsTime-dependent mannerAntiviral effectMNV infectionTherapeutic candidatePGE2Virus replicationMNV replicationPathophysiological conditionsInhibitory effectGenus SapovirusInfection
2017
Activation of COX-2/PGE2 Promotes Sapovirus Replication via the Inhibition of Nitric Oxide Production
Alfajaro M, Choi J, Kim D, Seo J, Kim J, Park J, Soliman M, Baek Y, Cho E, Kwon J, Kwon H, Park S, Lee W, Kang M, Hosmillo M, Goodfellow I, Cho K. Activation of COX-2/PGE2 Promotes Sapovirus Replication via the Inhibition of Nitric Oxide Production. Journal Of Virology 2017, 91: 10.1128/jvi.01656-16. PMID: 27881647, PMCID: PMC5244346, DOI: 10.1128/jvi.01656-16.Peer-Reviewed Original ResearchConceptsCOX/PGENonsteroidal anti-inflammatory drugsAnti-inflammatory drugsCOX-2Sapovirus infectionAcute gastroenteritisProstaglandin ECOX-1/2 inhibitor indomethacinAntiviral effector mechanismsCOX-2 specific inhibitor NS-398Severe acute gastroenteritisCOX-1 levelsInhibitor NS-398New targetsNitric oxide synthaseProduction of PGENitric oxide productionCOX-2 mRNASmall interfering RNAsPorcine sapovirusMajor etiological agentPotential new targetsInhibitor indomethacinOxide synthaseEffector mechanisms