Anti-rotaviral effects of Glycyrrhiza uralensis extract in piglets with rotavirus diarrhea
Alfajaro M, Kim H, Park J, Ryu E, Kim J, Jeong Y, Kim D, Hosmillo M, Son K, Lee J, Kwon H, Ryu Y, Park S, Park S, Lee W, Cho K. Anti-rotaviral effects of Glycyrrhiza uralensis extract in piglets with rotavirus diarrhea. Virology Journal 2012, 9: 310. PMID: 23244491, PMCID: PMC3547719, DOI: 10.1186/1743-422x-9-310.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAnti-Inflammatory Agents, Non-SteroidalAntiviral AgentsCell LineColostrumDiarrheaDose-Response Relationship, DrugDrug Evaluation, PreclinicalFecesGlycyrrhiza uralensisInterleukin-8Intestine, SmallMAP Kinase Signaling SystemModels, AnimalNF-kappa BPhytotherapyPlant ExtractsPlant RootsRNA, MessengerRotavirusRotavirus InfectionsSpleenSwineSwine DiseasesTumor Necrosis Factor-alphaVirus SheddingConceptsInflammation-related cytokinesGlycyrrhiza uralensis extractMRNA expression levelsSmall intestineRotavirus diarrheaRotaviral enteritisAnti-rotaviral effectAnti-inflammatory effectsFecal virus sheddingOnset of diarrheaColostrum-deprived pigletsExpression levelsIntestinal lesion scoresFecal consistency scoreAntiviral efficacyVirus sheddingHistological changesSevere gastroenteritisFecal virusAntiviral agentsDiarrheaLesion scoresViable medicationsHerbal medicineAntiviral properties