Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways.
Turner B, Zhang J, Gumbs A, Maher M, Kaplan L, Carter D, Glazer P, Hurst H, Haffty B, Williams T. Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways. Cancer Research 1998, 58: 5466-72. PMID: 9850080.Peer-Reviewed Original ResearchMeSH KeywordsBinding SitesBreastBreast NeoplasmsDNA-Binding ProteinsEpitheliumFemaleHumansImmunohistochemistryPrognosisPromoter Regions, GeneticReceptor, ErbB-2Receptor, IGF Type 1Receptors, EstrogenReceptors, Growth FactorReceptors, ProgesteroneSignal TransductionTranscription Factor AP-2Transcription FactorsTumor Cells, CulturedUp-RegulationConceptsAP-2 transcription factorsAP-2-binding sitesTranscription factorsAP-2gammaAP-2alphaAP-2 gene familyAP-2 geneAP-2 family membersInsulin-like growth factor I receptorAP-2 familySignal transduction moleculesAP-2 proteinsAP-2alpha proteinMammalian developmentGene familyHuman breast cancerGrowth factor receptorTransduction moleculesProximal promoterBreast cancerReceptor promoterMultiple growth factorsBreast cancer cell linesCell growthAP-2gamma expressionPrognostic significance of colony-stimulating factor receptor expression in ipsilateral breast cancer recurrence.
Maher M, Sapi E, Turner B, Gumbs A, Perrotta P, Carter D, Kacinski B, Haffty B. Prognostic significance of colony-stimulating factor receptor expression in ipsilateral breast cancer recurrence. Clinical Cancer Research 1998, 4: 1851-6. PMID: 9717811.Peer-Reviewed Original ResearchConceptsIpsilateral breast tumor recurrenceCSF-1R antibodyCSF-1R expressionIpsilateral breast cancer recurrenceBreast tumor recurrenceBreast cancer patientsBreast cancer recurrencePoor prognostic roleColony-stimulating factor receptor expressionCSF-1RFactor receptor expressionEarly stage IBreast carcinoma cellsDifferentiation of macrophagesConservative surgeryControl patientsLocal relapseNodal statusPrognostic roleDistant metastasisClinical stagePrognostic significanceCancer patientsTumor recurrenceCancer recurrence