1998
Prognostic significance of colony-stimulating factor receptor expression in ipsilateral breast cancer recurrence.
Maher M, Sapi E, Turner B, Gumbs A, Perrotta P, Carter D, Kacinski B, Haffty B. Prognostic significance of colony-stimulating factor receptor expression in ipsilateral breast cancer recurrence. Clinical Cancer Research 1998, 4: 1851-6. PMID: 9717811.Peer-Reviewed Original ResearchConceptsIpsilateral breast tumor recurrenceCSF-1R antibodyCSF-1R expressionIpsilateral breast cancer recurrenceBreast tumor recurrenceBreast cancer patientsBreast cancer recurrencePoor prognostic roleColony-stimulating factor receptor expressionCSF-1RFactor receptor expressionEarly stage IBreast carcinoma cellsDifferentiation of macrophagesConservative surgeryControl patientsLocal relapseNodal statusPrognostic roleDistant metastasisClinical stagePrognostic significanceCancer patientsTumor recurrenceCancer recurrence
1997
Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody
Flick M, Sapi E, Perrotta P, Maher M, Halaban R, Carter D, Kacinski B. Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody. Oncogene 1997, 14: 2553-2561. PMID: 9191055, DOI: 10.1038/sj.onc.1201092.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodiesAntibody SpecificityBreast NeoplasmsCarcinoma in SituCells, CulturedCross ReactionsEpitopesFibroblastsGenes, fmsHumansImmunohistochemistryMacrophagesMiceMice, Inbred BALB CPhosphopeptidesPhosphorylationPhosphotyrosineProto-Oncogene MasReceptor, Macrophage Colony-Stimulating FactorTumor Cells, CulturedConceptsCSF-1RMultiple signal transduction pathwaysC-fms proto-oncogenePhosphorylation state-specific antibodiesSignal transduction pathwaysCSF-1 receptorAnchorage-independent growthImmunoblots of lysatesActivation/phosphorylationEffector proteinsVivo phosphorylationCytoplasmic domainDifferentiation of macrophagesPhosphospecific antibodiesTransduction pathwaysCellular phenotypesInvasive human breast tumoursSpecific phosphopeptidesC-fms oncogeneCSF-1Proto-oncogeneHuman breast carcinomaFirst direct evidenceNormal proliferationFactor receptor