2024
The Right to Refuse Obstetrical Interventions: In Principle, in Practice
Malek J, Shamshirsaz A, Wilpers A, Premkumar A, Bahtiyar M. The Right to Refuse Obstetrical Interventions: In Principle, in Practice. The American Journal Of Bioethics 2024, 24: 44-45. PMID: 38295264, DOI: 10.1080/15265161.2023.2296428.Peer-Reviewed Original Research
2023
Early brain microstructural development among preterm infants requiring caesarean section versus those delivered vaginally
Bobba P, Weber C, Malhotra A, Bahtiyar M, Copel J, Taylor S, Ment L, Payabvash S. Early brain microstructural development among preterm infants requiring caesarean section versus those delivered vaginally. Scientific Reports 2023, 13: 21514. PMID: 38057452, PMCID: PMC10700578, DOI: 10.1038/s41598-023-48963-z.Peer-Reviewed Original Research
2020
Treatment and outcome of 370 cases with spontaneous or post‐laser twin anemia–polycythemia sequence managed in 17 fetal therapy centers
Tollenaar L, Slaghekke F, Lewi L, Ville Y, Lanna M, Weingertner A, Ryan G, Arévalo S, Khalil A, Brock C, Klaritsch P, Hecher K, Gardener G, Bevilacqua E, Kostyukov K, Bahtiyar M, Kilby M, Tiblad E, Oepkes D, Lopriore E, Middeldorp J, Haak M, Klumper F, Akkermans J, Delagrange H, Pandya V, Faiola S, Favre R, Hobson S, Rodo C, Thilaganathan B, Papanna R, Greimel P, de Sousa M, Carlin A, Gladkova K, Copel J. Treatment and outcome of 370 cases with spontaneous or post‐laser twin anemia–polycythemia sequence managed in 17 fetal therapy centers. Ultrasound In Obstetrics And Gynecology 2020, 56: 378-387. PMID: 32291846, PMCID: PMC7497010, DOI: 10.1002/uog.22042.Peer-Reviewed Original ResearchConceptsTwin anemia-polycythemia sequenceFetal therapy centersMonochorionic twin pregnanciesPost-laser twin anemia-polycythemia sequenceExpectant management groupSevere neonatal morbidityIntrauterine transfusionExpectant managementPerinatal mortalitySelective feticideTwin pregnanciesLaser surgeryNeonatal morbidityDelivery groupIUT groupDiagnosis of TAPSMiddle cerebral artery peak systolic velocityFetal middle cerebral artery peak systolic velocityBirth intervalLaser surgery groupProlongation of pregnancyTherapy CenterPeak systolic velocityLarge international cohortMedian diagnosisFetal interventions in the setting of the coronavirus disease 2019 pandemic: statement from the North American Fetal Therapy Network
Bahtiyar MO, Baschat A, Deprest J, Emery S, Goodnight W, Johnson A, McCullough L, Moldenhauer J, Ryan G, Tsao K, Van Mieghem T, Wagner A, Zaretsky M. Fetal interventions in the setting of the coronavirus disease 2019 pandemic: statement from the North American Fetal Therapy Network. American Journal Of Obstetrics And Gynecology 2020, 223: 281-284. PMID: 32348742, PMCID: PMC7194606, DOI: 10.1016/j.ajog.2020.04.025.Peer-Reviewed Original Research
2019
Antipsychotic Exposure in Pregnancy and the Risk of Gestational Diabetes: A Systematic Review and Meta-analysis
Kucukgoncu S, Guloksuz S, Celik K, Bahtiyar MO, Luykx JJ, Rutten BPF, Tek C. Antipsychotic Exposure in Pregnancy and the Risk of Gestational Diabetes: A Systematic Review and Meta-analysis. Schizophrenia Bulletin 2019, 46: 311-318. PMID: 31167033, PMCID: PMC7442324, DOI: 10.1093/schbul/sbz058.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusAntipsychotic exposureRisk ratioGDM riskHealthy controlsRisk of GDMControl groupSystematic reviewRisk of GestationalModifiable risk factorsConfidence intervalsCumulative risk ratioHealthy control groupSystematic literature searchLifestyle modificationDiabetes mellitusPrimary outcomeGestational ageAntipsychotic usePregnant womenRisk factorsStudy qualityExposure groupMeta-AnalysisPregnancy monitoringFetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation
Irani RA, Buhimschi CS, Cross SN, Zhao G, Copel JA, Bhandari V, Buhimschi IA, Bahtiyar MO. Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation. American Journal Of Perinatology 2019, 37: 745-753. PMID: 31121635, DOI: 10.1055/s-0039-1688909.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidBiomarkersChorioamnionitisEchocardiography, DopplerFemaleFetal BloodFetal HeartHumansInfant, NewbornInfant, PrematureInflammationInterleukin-6MaleMass SpectrometryNatriuretic Peptide, BrainPeptide FragmentsPlacentaPregnancyPremature BirthVentricular Function, LeftConceptsIntra-amniotic infection/inflammationBrain natriuretic proteinAmniotic fluidNT-proBNPTei indexNatriuretic proteinVentricular functionFetal exposureCord bloodCord IL-6Intra-amniotic inflammationFetal myocardial functionInfection/inflammationBlood NT-proBNPFetal heart functionNT-proBNP immunoassaysEnzyme-linked immunosorbentGestational agePremature fetusesFetal echocardiogramIL-6Circulatory levelsMyocardial functionHeart functionFetusesUtility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions
Tuzovic L, Copel JA, Stitelman DH, Levit O, Bahtiyar MO. Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions. Journal Of Ultrasound In Medicine 2019, 38: 2361-2372. PMID: 30653685, DOI: 10.1002/jum.14931.Peer-Reviewed Original ResearchConceptsAbnormal cardiac axisNegative predictive valueFetal cardiac axisNeonatal respiratory morbidityRespiratory morbidityCongenital lung lesionsCardiac positionPositive predictive valuePredictive valueCardiac axisLung lesionsHigh negative predictive valueSevere respiratory morbidityRetrospective cohort studyRight-sided lesionsNormal cardiac axisCohort studyWeeks' gestationMorbidityCP assessmentWeeksDiagnostic performanceLesionsPatientsGestation
2018
Deep-learned placental vessel segmentation for intraoperative video enhancement in fetoscopic surgery
Sadda P, Imamoglu M, Dombrowski M, Papademetris X, Bahtiyar MO, Onofrey J. Deep-learned placental vessel segmentation for intraoperative video enhancement in fetoscopic surgery. International Journal Of Computer Assisted Radiology And Surgery 2018, 14: 227-235. PMID: 30484115, PMCID: PMC6438174, DOI: 10.1007/s11548-018-1886-4.Peer-Reviewed Original ResearchCesarean Scar Pregnancy, Incidence, and Recurrence
Grechukhina O, Deshmukh U, Fan L, Kohari K, Abdel-Razeq S, Bahtiyar MO, Sfakianaki AK. Cesarean Scar Pregnancy, Incidence, and Recurrence. Obstetrics And Gynecology 2018, 132: 1285-1295. PMID: 30303911, DOI: 10.1097/aog.0000000000002940.Peer-Reviewed Original ResearchMeSH KeywordsAbortifacient Agents, NonsteroidalAdultCesarean SectionCicatrixCombined Modality TherapyCurettageFemaleHumansHysteroscopyMethotrexatePotassium ChloridePregnancyPregnancy RatePregnancy, EctopicRecurrenceTertiary Care CentersUterine Artery EmbolizationUterine Balloon TamponadeWatchful WaitingYoung AdultConceptsCesarean scar pregnancyScar pregnancySubsequent pregnancy outcomeLocal methotrexatePregnancy outcomesTreatment modalitiesRecurrent cesarean scar pregnancyBilateral uterine artery embolizationElectronic medical record reviewYale-New Haven HospitalSubsequent spontaneous conceptionViable intrauterine pregnancyPrior cesarean deliveryMedical record reviewTime of diagnosisUterine artery embolizationPotassium chloride injectionFetal cardiac activityProducts of conceptionIntrauterine pregnancyPregnancy characteristicsSystemic methotrexateExpectant managementMethotrexate therapyArtery embolizationTenascin-X in amniotic fluid and reproductive tissues of pregnancies complicated by infection and preterm prelabor rupture of membranes†
Rood KM, Buhimschi CS, Zhao G, Oliver EA, Summerfield T, Bahtiyar MO, Buhimschi IA. Tenascin-X in amniotic fluid and reproductive tissues of pregnancies complicated by infection and preterm prelabor rupture of membranes†. Biology Of Reproduction 2018, 100: 773-782. PMID: 30277495, PMCID: PMC6437262, DOI: 10.1093/biolre/ioy216.Peer-Reviewed Original ResearchConceptsIntra-amniotic infection/inflammationPreterm prelabor ruptureFetal membranesAmniotic fluidTNX expressionPrelabor ruptureInfection/inflammationLung maturity testingMembrane statusSpontaneous PPROMPregnancy complicationsNormal outcomeTherapeutic targetGenetic karyotypingReproductive tissuesPPROMMRNA expressionMaturity testingPregnancyWestern blottingMRNA levelsQRT-PCRExtracellular matrix proteinsCervixInflammationIn utero Partial Exchange Transfusion Combined with in utero Blood Transfusion for Prenatal Management of Twin Anemia-Polycythemia Sequence
Bahtiyar MO, Ekmekci E, Demirel E, Irani RA, Copel JA. In utero Partial Exchange Transfusion Combined with in utero Blood Transfusion for Prenatal Management of Twin Anemia-Polycythemia Sequence. Fetal Diagnosis And Therapy 2018, 45: 28-35. PMID: 29533957, DOI: 10.1159/000486198.Peer-Reviewed Original ResearchConceptsTwin anemia-polycythemia sequencePlacental vascular connectionsBlood transfusionTwin-twin transfusion syndromePartial exchange transfusionMonochorionic twin pregnanciesVascular connectionsFetoscopic laser photocoagulationLimited outcome dataAbsence of polyhydramniosAnemic twinPlacental territoryTAPS casesDonor twinRecipient twinPlacental sharingTransfusion syndromeChronic anemiaTwin pregnanciesDangerous complicationExchange transfusionPlacental vesselsUnique complicationsLaser photocoagulationPrenatal treatment
2017
Minimally invasive abdominal cerclage compared to laparotomy: a comparison of surgical and obstetric outcomes
Kim S, Hill A, Menderes G, Cross S, Azodi M, Bahtiyar MO. Minimally invasive abdominal cerclage compared to laparotomy: a comparison of surgical and obstetric outcomes. Journal Of Robotic Surgery 2017, 12: 295-301. PMID: 28721634, DOI: 10.1007/s11701-017-0726-9.Peer-Reviewed Original ResearchConceptsAbdominal cerclage placementAbdominal cerclageObstetric outcomesCerclage placementInvasive groupLive birthsYale-New Haven HospitalSubsequent obstetric outcomesRetrospective cohort studyAverage operative timeHigh-risk pregnanciesCohort of womenElectronic medical chartsRobotic-assisted laparoscopyInvasive gynecologic surgeryNew Haven HospitalElectronic medical recordsObstetric informationHospital stayCohort studyReferral centerBlood lossMedical chartsOperative timeGynecologic surgeryMaternal Anxiety Related to Prenatal Diagnoses of Fetal Anomalies That Require Surgery
Wilpers AB, Kennedy HP, Wall D, Funk M, Bahtiyar MO. Maternal Anxiety Related to Prenatal Diagnoses of Fetal Anomalies That Require Surgery. Journal Of Obstetric Gynecologic & Neonatal Nursing 2017, 46: 456-464. PMID: 28390224, DOI: 10.1016/j.jogn.2017.02.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxiety DisordersCase-Control StudiesCongenital AbnormalitiesFemaleFetusHumansMaternal AgeMothersNew EnglandPilot ProjectsPregnancyPregnancy OutcomePregnancy Trimester, SecondPregnancy Trimester, ThirdPregnancy, High-RiskPrenatal DiagnosisProspective StudiesReference ValuesRisk AssessmentUltrasonography, PrenatalConceptsNurse care coordinatorsFetal anomaliesMaternal ageMaternal anxietyAnxiety scoresComparison pilot studyOlder maternal ageEarly third trimesterHealth history dataU.S. academic medical centersFetal care centersAcademic medical centerMean state anxiety scoreSpielberger State-Trait Anxiety InventoryMental health issuesState-Trait Anxiety InventoryEmotional supportThird trimesterCare coordinatorsMedical recordsRisk factorsCare centerMedical CenterState anxiety scoresPregnancy
2016
Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes
Archabald KL, Buhimschi IA, Bahtiyar MO, Dulay AT, Abdel-Razeq SS, Pettker CM, Lipkind HS, Hardy JT, McCarthy ME, Zhao G, Bhandari V, Buhimschi CS. Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes. Fetal Diagnosis And Therapy 2016, 42: 99-110. PMID: 27794570, PMCID: PMC11588317, DOI: 10.1159/000450997.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisNeonatal outcomesPremature ruptureEarly deliveryIntrauterine infection/inflammationSetting of PPROMAdverse neonatal outcomesAmniotic fluid infectionPreterm premature ruptureShort-term outcomesInfection/inflammationIntra-amniotic infectionTerm neonatal outcomesSelect fetusesAntenatal exposureExpectant managementSingleton newbornsHospital dischargeNeonatal sepsisHaptoglobin-related proteinNewborn's riskFluid infectionGestational ageAdverse outcomesSelect subgroupEvidence for participation of neutrophil gelatinase‐associated lipocalin/matrix metalloproteinase‐9 (NGAL•MMP‐9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth
Rood KM, Buhimschi IA, Rodewald Millen K, Bahtiyar MO, Thung S, Summerfield T, Zhao G, Ackerman W, Shellhaas C, Samuels P, Buhimschi CS. Evidence for participation of neutrophil gelatinase‐associated lipocalin/matrix metalloproteinase‐9 (NGAL•MMP‐9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth. American Journal Of Reproductive Immunology 2016, 76: 108-117. PMID: 27251223, PMCID: PMC4942349, DOI: 10.1111/aji.12523.Peer-Reviewed Original ResearchConceptsIntra-amniotic infection/inflammationNeutrophil gelatinase-associated lipocalinMatrix metalloproteinase-9Preterm birthNGAL mRNA expressionGelatinase-associated lipocalinNormal pregnancy outcomeAmniotic fluid levelsInfection/inflammationPlacental villous trophoblastNGAL levelsPregnancy outcomesInflammatory conditionsInflammatory responseMetalloproteinase-9Villous trophoblastFluid levelsInnate immunityCollagenolytic effectMRNA expressionGelatinolytic activityPregnancyHost-microbe interactionsQRT-PCRAmniochorion
2015
The North American Fetal Therapy Network Consensus Statement
Emery SP, Bahtiyar MO, Moise KJ. The North American Fetal Therapy Network Consensus Statement. Obstetrics And Gynecology 2015, 126: 575-584. PMID: 26244534, DOI: 10.1097/aog.0000000000000994.Peer-Reviewed Original ResearchConceptsNorth American Fetal Therapy NetworkBetter patient counselingMonochorionic gestationsRegional treatment centreMonochorionic pregnanciesMultidisciplinary careTimely referralPatient counselingConsensus statementFetal therapyObstetric practitionersFetal disordersTreatment centersTherapy NetworkMedical institutionsManagement optionsNAFTNetComplicationsPregnancyGestationPathophysiologyReferralTherapyScreening for Congenital Heart Disease During Anatomical Survey Ultrasonography
Bahtiyar MO, Copel JA. Screening for Congenital Heart Disease During Anatomical Survey Ultrasonography. Obstetrics And Gynecology Clinics Of North America 2015, 42: 209-223. PMID: 26002162, DOI: 10.1016/j.ogc.2015.01.001.Peer-Reviewed Original ResearchConceptsCongenital heart diseasePrevalence of CHDFetal heart examinationCommon congenital abnormalityPrenatal ultrasound examinationNeonatal outcomesHeart diseaseUltrasound examinationHeart examinationHigh prevalenceLive birthsCongenital abnormalitiesPrevalenceAbnormalitiesDetection rateRegular feedbackTraining programExaminationCompartmentalization of acute phase reactants Interleukin-6, C-Reactive Protein and Procalcitonin as biomarkers of intra-amniotic infection and chorioamnionitis
Dulay AT, Buhimschi IA, Zhao G, Bahtiyar MO, Thung SF, Cackovic M, Buhimschi CS. Compartmentalization of acute phase reactants Interleukin-6, C-Reactive Protein and Procalcitonin as biomarkers of intra-amniotic infection and chorioamnionitis. Cytokine 2015, 76: 236-243. PMID: 25957466, PMCID: PMC4824401, DOI: 10.1016/j.cyto.2015.04.014.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidAsymptomatic InfectionsBiomarkersCalcitoninCalcitonin Gene-Related PeptideChorioamnionitisC-Reactive ProteinFemaleFetal BloodFetal Membranes, Premature RuptureHumansInfant, NewbornInterleukin-6Obstetric Labor, PrematurePlacentaPregnancyPregnancy Complications, InfectiousPremature BirthProtein PrecursorsSystemic Inflammatory Response SyndromeConceptsIntra-amniotic infectionC-reactive proteinSubclinical intra-amniotic infectionIL-6Blood IL-6 levelsBlood IL-6Maternal blood levelsSystemic inflammatory responseIL-6 levelsNon-invasive biomarkersSubgroup of casesChorioamnionitis groupHistological chorioamnionitisInflammatory markersPreterm laborCRP levelsInflammatory biomarkersMaternal serumPlacental pathologyAcute phasePregnant womenBlood levelsSubclinical phaseInterleukin-6Cord bloodThe North American Fetal Therapy Network Consensus Statement
Emery SP, Bahtiyar MO, Dashe JS, Wilkins-Haug LE, Johnson A, Paek BW, Moon-Grady AJ, Skupski DW, O'Brien BM, Harman CR, Simpson LL. The North American Fetal Therapy Network Consensus Statement. Obstetrics And Gynecology 2015, 125: 1236-1243. PMID: 25932853, DOI: 10.1097/aog.0000000000000723.Peer-Reviewed Original ResearchConceptsMonochorionic gestationsNorth American Fetal Therapy NetworkUnequal placental sharingDetection of complicationsUnique disease processDichorionic gestationsUltrasonographic surveillanceEarly referralPlacental sharingPermanent disabilityConsensus statementPrenatal managementBetter outcomesDisease processClinical practiceGestationSingle placentaTherapy NetworkEarly detectionComplicationsVascular connectionsDeathSurveillanceReferralAngioarchitectureAmniotic Fluid Soluble Myeloid Differentiation‐2 (sMD‐2) as Regulator of Intra‐amniotic Inflammation in Infection‐induced Preterm Birth
Dulay AT, Buhimschi CS, Zhao G, Oliver EA, Abdel-Razeq SS, Shook LL, Bahtiyar MO, Buhimschi IA. Amniotic Fluid Soluble Myeloid Differentiation‐2 (sMD‐2) as Regulator of Intra‐amniotic Inflammation in Infection‐induced Preterm Birth. American Journal Of Reproductive Immunology 2015, 73: 507-521. PMID: 25605324, PMCID: PMC4430418, DOI: 10.1111/aji.12362.Peer-Reviewed Original ResearchConceptsMyeloid differentiation 2Preterm birthSMD-2Fetal membranesInflammation-induced preterm birthHuman AFIntra-amniotic inflammatory responseInfection-induced preterm birthIntra-amniotic inflammationIL-6 levelsNormal pregnancy outcomeDifferentiation 2MD-2 mRNATime-dependent fashionPregnancy outcomesImmunohistochemistry findingsTLR4 ligandInflammatory cytokinesInflammatory responseHost responseMRNA expressionLevel of expressionWestern blottingHistological localizationAF samples