2019
Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions
Tuzovic L, Copel JA, Stitelman DH, Levit O, Bahtiyar MO. Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions. Journal Of Ultrasound In Medicine 2019, 38: 2361-2372. PMID: 30653685, DOI: 10.1002/jum.14931.Peer-Reviewed Original ResearchConceptsAbnormal cardiac axisNegative predictive valueFetal cardiac axisNeonatal respiratory morbidityRespiratory morbidityCongenital lung lesionsCardiac positionPositive predictive valuePredictive valueCardiac axisLung lesionsHigh negative predictive valueSevere respiratory morbidityRetrospective cohort studyRight-sided lesionsNormal cardiac axisCohort studyWeeks' gestationMorbidityCP assessmentWeeksDiagnostic performanceLesionsPatientsGestation
2018
Cesarean Scar Pregnancy, Incidence, and Recurrence
Grechukhina O, Deshmukh U, Fan L, Kohari K, Abdel-Razeq S, Bahtiyar MO, Sfakianaki AK. Cesarean Scar Pregnancy, Incidence, and Recurrence. Obstetrics And Gynecology 2018, 132: 1285-1295. PMID: 30303911, DOI: 10.1097/aog.0000000000002940.Peer-Reviewed Original ResearchMeSH KeywordsAbortifacient Agents, NonsteroidalAdultCesarean SectionCicatrixCombined Modality TherapyCurettageFemaleHumansHysteroscopyMethotrexatePotassium ChloridePregnancyPregnancy RatePregnancy, EctopicRecurrenceTertiary Care CentersUterine Artery EmbolizationUterine Balloon TamponadeWatchful WaitingYoung AdultConceptsCesarean scar pregnancyScar pregnancySubsequent pregnancy outcomeLocal methotrexatePregnancy outcomesTreatment modalitiesRecurrent cesarean scar pregnancyBilateral uterine artery embolizationElectronic medical record reviewYale-New Haven HospitalSubsequent spontaneous conceptionViable intrauterine pregnancyPrior cesarean deliveryMedical record reviewTime of diagnosisUterine artery embolizationPotassium chloride injectionFetal cardiac activityProducts of conceptionIntrauterine pregnancyPregnancy characteristicsSystemic methotrexateExpectant managementMethotrexate therapyArtery embolizationTenascin-X in amniotic fluid and reproductive tissues of pregnancies complicated by infection and preterm prelabor rupture of membranes†
Rood KM, Buhimschi CS, Zhao G, Oliver EA, Summerfield T, Bahtiyar MO, Buhimschi IA. Tenascin-X in amniotic fluid and reproductive tissues of pregnancies complicated by infection and preterm prelabor rupture of membranes†. Biology Of Reproduction 2018, 100: 773-782. PMID: 30277495, PMCID: PMC6437262, DOI: 10.1093/biolre/ioy216.Peer-Reviewed Original ResearchConceptsIntra-amniotic infection/inflammationPreterm prelabor ruptureFetal membranesAmniotic fluidTNX expressionPrelabor ruptureInfection/inflammationLung maturity testingMembrane statusSpontaneous PPROMPregnancy complicationsNormal outcomeTherapeutic targetGenetic karyotypingReproductive tissuesPPROMMRNA expressionMaturity testingPregnancyWestern blottingMRNA levelsQRT-PCRExtracellular matrix proteinsCervixInflammation
2016
Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes
Archabald KL, Buhimschi IA, Bahtiyar MO, Dulay AT, Abdel-Razeq SS, Pettker CM, Lipkind HS, Hardy JT, McCarthy ME, Zhao G, Bhandari V, Buhimschi CS. Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes. Fetal Diagnosis And Therapy 2016, 42: 99-110. PMID: 27794570, PMCID: PMC11588317, DOI: 10.1159/000450997.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisNeonatal outcomesPremature ruptureEarly deliveryIntrauterine infection/inflammationSetting of PPROMAdverse neonatal outcomesAmniotic fluid infectionPreterm premature ruptureShort-term outcomesInfection/inflammationIntra-amniotic infectionTerm neonatal outcomesSelect fetusesAntenatal exposureExpectant managementSingleton newbornsHospital dischargeNeonatal sepsisHaptoglobin-related proteinNewborn's riskFluid infectionGestational ageAdverse outcomesSelect subgroup
2014
Doppler abnormalities in monochorionic diamniotic twin pregnancies with discordant growth
Zuckerwise L, Nayeri U, Abdel-Razeq S, Copel J, Bahtiyar M. Doppler abnormalities in monochorionic diamniotic twin pregnancies with discordant growth. Journal Of Perinatology 2014, 35: 387-389. PMID: 25521562, DOI: 10.1038/jp.2014.223.Peer-Reviewed Original ResearchConceptsDoppler flow velocity waveformsFlow velocity waveformsDiscordant growthVelocity waveformsTwin gestationsSmall fetusesAbnormal umbilical artery Doppler flow velocity waveformsUmbilical artery Doppler flow velocity waveformsMonochorionic diamniotic twin gestationsMonochorionic diamniotic twin pregnanciesNeonatal intensive care unitDiamniotic twin gestationsMCDA twin pairsDiamniotic twin pregnanciesEnd-diastolic flowLow Apgar scoreBirth weight discordanceDiscordant fetal growthIntensive care unitTwin transfusion syndromeDoppler velocity waveformsT-testElectronic medical recordsTwin pairsStudent's t-test
2011
Neoadjuvant and Adjuvant Chemotherapy of Cervical Cancer
McCaffrey R, Bahtiyar M, Kohorn EI, Chambers JT, Schwartz PE, Chambers SK. Neoadjuvant and Adjuvant Chemotherapy of Cervical Cancer. International Journal Of Gynecological Cancer 2011, 21: 535-544. PMID: 21436702, DOI: 10.1097/igc.0b013e31820c4c8d.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAntineoplastic Combined Chemotherapy ProtocolsBleomycinCarcinoma, AdenosquamousCarcinoma, Squamous CellChemotherapy, AdjuvantCisplatinFemaleFluorouracilHumansLeucovorinMaximum Tolerated DoseMethotrexateMiddle AgedNeoadjuvant TherapyNeoplasm Recurrence, LocalNeoplasm StagingProspective StudiesSurvival RateTreatment OutcomeUterine Cervical NeoplasmsYoung AdultConceptsLymph nodesRadiation therapyResponse rateSurvival ratePathologic complete response rateCisplatin-based neoadjuvant chemotherapyAdjuvant chemotherapy armComplete response rateConsolidation radiation therapyStage IIB cancerDisease-free survivalHigh-risk featuresPercent of patientsPositive lymph nodesPostoperative radiation therapyChemotherapy response rateAdjuvant casesAdjuvant chemotherapyChemotherapy armChemotherapy eraNeoadjuvant groupNonsquamous histologyNeoadjuvant chemotherapyAdjuvant groupOverall survivalIL-6 Trans-Signaling System in Intra-Amniotic Inflammation, Preterm Birth, and Preterm Premature Rupture of the Membranes
Lee SY, Buhimschi IA, Dulay AT, Ali UA, Zhao G, Abdel-Razeq SS, Bahtiyar MO, Thung SF, Funai EF, Buhimschi CS. IL-6 Trans-Signaling System in Intra-Amniotic Inflammation, Preterm Birth, and Preterm Premature Rupture of the Membranes. The Journal Of Immunology 2011, 186: 3226-3236. PMID: 21282511, PMCID: PMC3800180, DOI: 10.4049/jimmunol.1003587.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidCytokine Receptor gp130FemaleFetal Membranes, Premature RuptureHumansInfant, NewbornInfant, PrematureInflammation MediatorsInterleukin-6Matrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsPregnancyPregnancy ComplicationsPremature BirthReceptors, Interleukin-6Signal TransductionYoung AdultConceptsIntra-amniotic inflammationSIL-6RIL-6RPremature ruptureIL-6Classic IL-6 signalingAF IL-6RT-PCRPreterm premature ruptureIL-6 signalingMatrix metalloprotease-9Real-time RT-PCRActivation of cellsPhysiologic constituentPreterm laborPreterm birthIL-6 TransGestational ageThird trimesterInflammatory cellsSecond trimesterNormal gestationMetalloprotease-9IL-6 bindsFetal membranes
2010
The role of urinary soluble endoglin in the diagnosis of pre‐eclampsia: comparison with soluble fms‐like tyrosine kinase 1 to placental growth factor ratio
Buhimschi C, Baumbusch M, Dulay A, Lee S, Wehrum M, Zhao G, Bahtiyar M, Pettker C, Ali U, Funai E, Buhimschi I. The role of urinary soluble endoglin in the diagnosis of pre‐eclampsia: comparison with soluble fms‐like tyrosine kinase 1 to placental growth factor ratio. BJOG An International Journal Of Obstetrics & Gynaecology 2010, 117: 321-330. PMID: 19943826, DOI: 10.1111/j.1471-0528.2009.02434.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntigens, CDBiomarkersChronic DiseaseDiagnosis, DifferentialEndoglinFemaleGrowth HormoneHumansHypertensionPlacental HormonesPre-EclampsiaPregnancyPregnancy Complications, CardiovascularProspective StudiesReceptors, Cell SurfaceSensitivity and SpecificityVascular Endothelial Growth Factor Receptor-1Young AdultConceptsSoluble fms-like tyrosine kinase-1Fms-like tyrosine kinase-1Tyrosine kinase-1Placental growth factor ratioGrowth factor ratioSoluble endoglinDiagnosis of PEGestational agePlGF ratioChronic hypertensionHealthy controlsPreterm PEUrinary levelsSevere PEMild PEWeeks of GATertiary referral university hospitalKinase 1Prospective observational cohortSoluble endoglin levelsReferral university hospitalWeeks of gestationIdentification of womenSeverity of PEUrine of women
2009
Fetal renal artery impedance as assessed by Doppler ultrasound in pregnancies complicated by intraamniotic inflammation and preterm birth
Azpurua H, Dulay AT, Buhimschi IA, Bahtiyar MO, Funai E, Abdel-Razeq SS, Luo G, Bhandari V, Copel JA, Buhimschi CS. Fetal renal artery impedance as assessed by Doppler ultrasound in pregnancies complicated by intraamniotic inflammation and preterm birth. American Journal Of Obstetrics And Gynecology 2009, 200: 203.e1-203.e11. PMID: 19185102, PMCID: PMC3791328, DOI: 10.1016/j.ajog.2008.11.001.Peer-Reviewed Original ResearchConceptsCord blood IL-6End-diastolic blood flowRenal artery pulsatility indexArtery pulsatility indexBlood IL-6Amniotic fluid indexIntraamniotic inflammationResistance indexPulsatility indexPreterm birthIL-6Blood flowSerum blood urea nitrogen levelAF IL-6 levelsInflammation-associated preterm birthRenal artery resistance indexSystolic/diastolic ratioBlood urea nitrogen levelsAge-reference rangeCord blood interleukinRenal vascular bedIL-6 levelsHours of lifeUrea nitrogen levelsBlood interleukin
2008
Acute Chest Syndrome during Pregnancy as Initial Presentation of Sickle Cell Disease: A Case Report
Campbell K, Ali U, Bahtiyar M. Acute Chest Syndrome during Pregnancy as Initial Presentation of Sickle Cell Disease: A Case Report. American Journal Of Perinatology 2008, 25: 547-549. PMID: 18756432, DOI: 10.1055/s-0028-1085628.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnemia, Sickle CellCesarean SectionChest PainDiagnosis, DifferentialErythrocyte TransfusionFemaleHumansPlasmapheresisPostnatal CarePregnancyPregnancy Complications, HematologicPregnancy OutcomePregnancy Trimester, ThirdPrenatal CareRespiratory InsufficiencyRisk AssessmentSeverity of Illness IndexSyndromeYoung Adult