2016
Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes
Archabald KL, Buhimschi IA, Bahtiyar MO, Dulay AT, Abdel-Razeq SS, Pettker CM, Lipkind HS, Hardy JT, McCarthy ME, Zhao G, Bhandari V, Buhimschi CS. Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes. Fetal Diagnosis And Therapy 2016, 42: 99-110. PMID: 27794570, PMCID: PMC11588317, DOI: 10.1159/000450997.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisNeonatal outcomesPremature ruptureEarly deliveryIntrauterine infection/inflammationSetting of PPROMAdverse neonatal outcomesAmniotic fluid infectionPreterm premature ruptureShort-term outcomesInfection/inflammationIntra-amniotic infectionTerm neonatal outcomesSelect fetusesAntenatal exposureExpectant managementSingleton newbornsHospital dischargeNeonatal sepsisHaptoglobin-related proteinNewborn's riskFluid infectionGestational ageAdverse outcomesSelect subgroup
2011
IL-6 Trans-Signaling System in Intra-Amniotic Inflammation, Preterm Birth, and Preterm Premature Rupture of the Membranes
Lee SY, Buhimschi IA, Dulay AT, Ali UA, Zhao G, Abdel-Razeq SS, Bahtiyar MO, Thung SF, Funai EF, Buhimschi CS. IL-6 Trans-Signaling System in Intra-Amniotic Inflammation, Preterm Birth, and Preterm Premature Rupture of the Membranes. The Journal Of Immunology 2011, 186: 3226-3236. PMID: 21282511, PMCID: PMC3800180, DOI: 10.4049/jimmunol.1003587.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidCytokine Receptor gp130FemaleFetal Membranes, Premature RuptureHumansInfant, NewbornInfant, PrematureInflammation MediatorsInterleukin-6Matrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsPregnancyPregnancy ComplicationsPremature BirthReceptors, Interleukin-6Signal TransductionYoung AdultConceptsIntra-amniotic inflammationSIL-6RIL-6RPremature ruptureIL-6Classic IL-6 signalingAF IL-6RT-PCRPreterm premature ruptureIL-6 signalingMatrix metalloprotease-9Real-time RT-PCRActivation of cellsPhysiologic constituentPreterm laborPreterm birthIL-6 TransGestational ageThird trimesterInflammatory cellsSecond trimesterNormal gestationMetalloprotease-9IL-6 bindsFetal membranes
2006
Lactate dehydrogenase (LDH) isoform activity in the vaginal “pool” - a marker of intra-amniotic infection in women with preterm premature rupture of membranes
Magloire L, Buhimschi C, Pettker C, Abdel-Razeq S, Rosenberg V, Cackovic M, Bahtiyar M, Buhimschi I. Lactate dehydrogenase (LDH) isoform activity in the vaginal “pool” - a marker of intra-amniotic infection in women with preterm premature rupture of membranes. American Journal Of Obstetrics And Gynecology 2006, 195: s64. DOI: 10.1016/j.ajog.2006.10.199.Peer-Reviewed Original ResearchA low vaginal “pool” amniotic fluid glucose measurement is a predictive but not a sensitive marker for infection in women with preterm premature rupture of membranes
Buhimschi CS, Sfakianaki AK, Hamar BG, Pettker CM, Bahtiyar MO, Funai E, Norwitz ER, Copel JA, Lockwood CJ, Buhimschi IA. A low vaginal “pool” amniotic fluid glucose measurement is a predictive but not a sensitive marker for infection in women with preterm premature rupture of membranes. American Journal Of Obstetrics And Gynecology 2006, 194: 309-316. PMID: 16458622, DOI: 10.1016/j.ajog.2005.07.070.Peer-Reviewed Original ResearchConceptsIntra-amniotic infectionPreterm premature rupturePredictive valuePremature ruptureGlucose measurementsCohen's kappa measureGlucose levelsGlucose concentrationIntra-amniotic infection/inflammationEnd of enrollmentInfection/inflammationRed blood cell countBlood cell countPositive microbial culturesNegative AF cultureCharacteristic curve analysisNegative microbial culturesNegative predictive valuePositive predictive valueClinical laboratory analysisKappa measureConsecutive womenNoninfected groupTransabdominal amniocentesisSensitive marker
2004
Defining standards of care in maternal-fetal medicine
Norwitz ER, Bahtiyar MO, Sibai BM. Defining standards of care in maternal-fetal medicine. American Journal Of Obstetrics And Gynecology 2004, 191: 1491-1496. PMID: 15507989, DOI: 10.1016/j.ajog.2004.06.043.Peer-Reviewed Original ResearchConceptsMaternal-fetal medicineCurrent practice patternsStandard of carePractice patternsMagnesium sulfate seizure prophylaxisMaternal-fetal medicine specialistsObstetric care providersPreterm premature ruptureContemporary practice patternsUniversity-based settingCervical cerclageSeizure prophylaxisTocolytic therapyHELLP syndromePreterm birthObstetric treatmentProgesterone supplementationPremature ruptureObstetric medicineCare providersMedicine specialistsControversial topicSpecialty trainingTherapyControversial areas