2018
A Novel Approach to Serial Amnioinfusion in a Case of Premature Rupture of Membranes Near the Limit of Viability
Kohari K, Mehlhaff K, Merriam A, Abdel-Razeq S, Grechukhina O, Leon-Martinez D, Bahtiyar MO. A Novel Approach to Serial Amnioinfusion in a Case of Premature Rupture of Membranes Near the Limit of Viability. American Journal Of Perinatology Reports 2018, 08: e180-e183. PMID: 30250757, PMCID: PMC6138466, DOI: 10.1055/s-0038-1669964.Peer-Reviewed Original ResearchLimit of viabilityIntra-amniotic infectionSerial transabdominal amnioinfusionsIntra-amniotic infusionSerial amnioinfusionsMaternal morbidityPlacental abruptionPreterm laborTransabdominal amnioinfusionPrelabor rupturePulmonary hypoplasiaPremature rupturePersistent oligohydramniosNormal salineNeonatal survivalLatency periodClinical scenariosAdditional riskSignificant riskAmnioinfusionRiskFetusesInfectionImmediate riskRupture
2016
Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes
Archabald KL, Buhimschi IA, Bahtiyar MO, Dulay AT, Abdel-Razeq SS, Pettker CM, Lipkind HS, Hardy JT, McCarthy ME, Zhao G, Bhandari V, Buhimschi CS. Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes. Fetal Diagnosis And Therapy 2016, 42: 99-110. PMID: 27794570, PMCID: PMC11588317, DOI: 10.1159/000450997.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisNeonatal outcomesPremature ruptureEarly deliveryIntrauterine infection/inflammationSetting of PPROMAdverse neonatal outcomesAmniotic fluid infectionPreterm premature ruptureShort-term outcomesInfection/inflammationIntra-amniotic infectionTerm neonatal outcomesSelect fetusesAntenatal exposureExpectant managementSingleton newbornsHospital dischargeNeonatal sepsisHaptoglobin-related proteinNewborn's riskFluid infectionGestational ageAdverse outcomesSelect subgroup
2015
Compartmentalization of acute phase reactants Interleukin-6, C-Reactive Protein and Procalcitonin as biomarkers of intra-amniotic infection and chorioamnionitis
Dulay AT, Buhimschi IA, Zhao G, Bahtiyar MO, Thung SF, Cackovic M, Buhimschi CS. Compartmentalization of acute phase reactants Interleukin-6, C-Reactive Protein and Procalcitonin as biomarkers of intra-amniotic infection and chorioamnionitis. Cytokine 2015, 76: 236-243. PMID: 25957466, PMCID: PMC4824401, DOI: 10.1016/j.cyto.2015.04.014.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidAsymptomatic InfectionsBiomarkersCalcitoninCalcitonin Gene-Related PeptideChorioamnionitisC-Reactive ProteinFemaleFetal BloodFetal Membranes, Premature RuptureHumansInfant, NewbornInterleukin-6Obstetric Labor, PrematurePlacentaPregnancyPregnancy Complications, InfectiousPremature BirthProtein PrecursorsSystemic Inflammatory Response SyndromeConceptsIntra-amniotic infectionC-reactive proteinSubclinical intra-amniotic infectionIL-6Blood IL-6 levelsBlood IL-6Maternal blood levelsSystemic inflammatory responseIL-6 levelsNon-invasive biomarkersSubgroup of casesChorioamnionitis groupHistological chorioamnionitisInflammatory markersPreterm laborCRP levelsInflammatory biomarkersMaternal serumPlacental pathologyAcute phasePregnant womenBlood levelsSubclinical phaseInterleukin-6Cord blood
2013
836: Limiting exposure of a select group of fetuses to intra-amniotic infection (IAI) may improve short-term neonatal outcome in pregnancies complicated by PPROM
Archabald K, Buhimschi I, Bahtiyar M, Dulay A, Abdel-Razeq S, Pettker C, Lipkind H, Hardy J, McCarthy M, Zhao G, Bhandari V, Buhimschi C. 836: Limiting exposure of a select group of fetuses to intra-amniotic infection (IAI) may improve short-term neonatal outcome in pregnancies complicated by PPROM. American Journal Of Obstetrics And Gynecology 2013, 208: s349-s350. DOI: 10.1016/j.ajog.2012.10.174.Peer-Reviewed Original ResearchIntra-amniotic infectionShort-term neonatal outcomesNeonatal outcomesSelect groupPPROMPregnancyFetusesInfection
2011
625: Systematic evaluation of prototype acute phase reactants [Interleukin-6 (IL-6), C-reactive protein (CRP) and procalcitonin (PCT)] as non-invasive biomarkers of intra-amniotic infection (IAI)
Dulay A, Buhimschi I, Zhao G, Ali U, Abdel-Razeq S, Bahtiyar M, Thung S, Han C, Campbell K, Paidas M, Buhimschi C. 625: Systematic evaluation of prototype acute phase reactants [Interleukin-6 (IL-6), C-reactive protein (CRP) and procalcitonin (PCT)] as non-invasive biomarkers of intra-amniotic infection (IAI). American Journal Of Obstetrics And Gynecology 2011, 204: s248. DOI: 10.1016/j.ajog.2010.10.645.Peer-Reviewed Original Research
2007
The receptor for advanced glycation end products (RAGE) system in women with intraamniotic infection and inflammation
Buhimschi IA, Zhao G, Pettker CM, Bahtiyar MO, Magloire LK, Thung S, Fairchild T, Buhimschi CS. The receptor for advanced glycation end products (RAGE) system in women with intraamniotic infection and inflammation. American Journal Of Obstetrics And Gynecology 2007, 196: 181.e1-181.e13. PMID: 17306673, DOI: 10.1016/j.ajog.2006.09.001.Peer-Reviewed Original ResearchConceptsIntra-amniotic infectionPolymerase chain reactionAF cultureAdvanced glycation end productsAmniotic fluid inflammationThird-trimester controlsEarlier gestational agePlacental villous tissueDegree of inflammationAcute histologic chorioamnionitisNegative AF culturePositive AF cultureExtravillous trophoblast cellsGlycation end productsGestational age dependenceReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionHistologic chorioamnionitisIntraamniotic infectionPreterm deliveryInflammatory biomarkersPlacental pathologyGestational ageRAGE systemAcute inflammationProteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis
Buhimschi CS, Bhandari V, Hamar BD, Bahtiyar MO, Zhao G, Sfakianaki AK, Pettker CM, Magloire L, Funai E, Norwitz ER, Paidas M, Copel JA, Weiner CP, Lockwood CJ, Buhimschi IA. Proteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis. PLOS Medicine 2007, 4: e18. PMID: 17227133, PMCID: PMC1769412, DOI: 10.1371/journal.pmed.0040018.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmniocentesisAmniotic FluidBiomarkersFemaleHumansInflammationMiddle AgedPregnancyPregnancy Complications, InfectiousPregnancy OutcomeProteomeProteomicsReproducibility of ResultsSensitivity and SpecificitySepsisSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationConceptsEarly-onset neonatal sepsisAmniotic fluid inflammationIntra-amniotic infectionMR scoreNeonatal sepsisAmniotic fluidHistological chorioamnionitisDelivery intervalNewborn Special Care UnitGram stainEarly-onset sepsisIntra-amniotic inflammationDegree of inflammationSpecial care unitsIntrauterine inflammationPlacental inflammationShorter amniocentesisPreterm deliveryPreterm laborSingleton pregnanciesConsecutive womenPreterm birthCare unitGestational agePremature rupture
2006
Lactate dehydrogenase (LDH) isoform activity in the vaginal “pool” - a marker of intra-amniotic infection in women with preterm premature rupture of membranes
Magloire L, Buhimschi C, Pettker C, Abdel-Razeq S, Rosenberg V, Cackovic M, Bahtiyar M, Buhimschi I. Lactate dehydrogenase (LDH) isoform activity in the vaginal “pool” - a marker of intra-amniotic infection in women with preterm premature rupture of membranes. American Journal Of Obstetrics And Gynecology 2006, 195: s64. DOI: 10.1016/j.ajog.2006.10.199.Peer-Reviewed Original ResearchA low vaginal “pool” amniotic fluid glucose measurement is a predictive but not a sensitive marker for infection in women with preterm premature rupture of membranes
Buhimschi CS, Sfakianaki AK, Hamar BG, Pettker CM, Bahtiyar MO, Funai E, Norwitz ER, Copel JA, Lockwood CJ, Buhimschi IA. A low vaginal “pool” amniotic fluid glucose measurement is a predictive but not a sensitive marker for infection in women with preterm premature rupture of membranes. American Journal Of Obstetrics And Gynecology 2006, 194: 309-316. PMID: 16458622, DOI: 10.1016/j.ajog.2005.07.070.Peer-Reviewed Original ResearchConceptsIntra-amniotic infectionPreterm premature rupturePredictive valuePremature ruptureGlucose measurementsCohen's kappa measureGlucose levelsGlucose concentrationIntra-amniotic infection/inflammationEnd of enrollmentInfection/inflammationRed blood cell countBlood cell countPositive microbial culturesNegative AF cultureCharacteristic curve analysisNegative microbial culturesNegative predictive valuePositive predictive valueClinical laboratory analysisKappa measureConsecutive womenNoninfected groupTransabdominal amniocentesisSensitive marker