2010
Chronic kidney disease induced in mice by reversible unilateral ureteral obstruction is dependent on genetic background
Puri T, Shakaib M, Chang A, Mathew L, Olayinka O, Minto A, Sarav M, Hack B, Quigg R. Chronic kidney disease induced in mice by reversible unilateral ureteral obstruction is dependent on genetic background. American Journal Of Physiology. Renal Physiology 2010, 298: f1024-f1032. PMID: 20089676, PMCID: PMC2853313, DOI: 10.1152/ajprenal.00384.2009.Peer-Reviewed Original ResearchConceptsReversible unilateral ureteral obstructionChronic kidney diseaseUnilateral ureteral obstructionDevelopment of chronic kidney diseaseUreteral obstructionBlood urea nitrogenC57BL/6 miceResistant to chronic kidney diseaseBALB/c miceKidney diseaseModel of chronic kidney diseaseDays of ureteral obstructionRelease of ureteral obstructionModel of renal fibrosisBackground Chronic kidney diseaseProliferative cellular responseResponse to injuryRenal injuryRenal fibrosisRenal architectureObstructionUrea nitrogenMiceC57BL/6Injury
2009
Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG
Sarav M, Wang Y, Hack B, Chang A, Jensen M, Bao L, Quigg R. Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG. Journal Of The American Society Of Nephrology 2009, 20: 1941-1952. PMID: 19661163, PMCID: PMC2736763, DOI: 10.1681/asn.2008090976.Peer-Reviewed Original ResearchConceptsElimination of IgGFcRn(-/-Renal lossFcRn(-/-) miceMinimal urinary excretionSerum albumin levelWild-type miceWild-type kidneysSerum concentrations of albuminProximal tubular epitheliumWild-type controlsDevelopment of hypoalbuminemiaNeonatal Fc receptorLoss of IgGLoss of albuminSerum levelsAlbumin levelsIncreased to wild-type levelsUrinary excretionSerum concentrationsFc receptorsTubular epitheliumConcentrations of albuminPlasma protein poolKidneyMesangial cell complement receptor 1‐related protein y limits complement‐dependent neutrophil accumulation in immune complex glomerulonephritis
Bao L, Wang Y, Chen P, Sarav M, Haas M, Minto A, Petkova M, Quigg R. Mesangial cell complement receptor 1‐related protein y limits complement‐dependent neutrophil accumulation in immune complex glomerulonephritis. Immunology 2009, 128: e895-e904. PMID: 19740350, PMCID: PMC2753953, DOI: 10.1111/j.1365-2567.2009.03102.x.Peer-Reviewed Original ResearchConceptsWild-type miceImmune complex glomerulonephritisCrry(-/-Complement receptor 1Weeks of immunizationNeutrophil infiltrationExpression of decay-accelerating factorMouse kidneyAlpha-smooth muscle actinLimits complement activationSerum C3 levelsImmune complex depositionProliferating cell nuclear antigenPathogenesis of immune complex glomerulonephritisCell nuclear antigenMesangial cell proliferationDecay-accelerating factorAbsent stainingRenal expressionC3 levelsProliferative GNNeutrophil recruitmentGlomerular hypercellularityNeutrophil accumulationLevels several-fold