Mesangial cell complement receptor 1‐related protein y limits complement‐dependent neutrophil accumulation in immune complex glomerulonephritis
Bao L, Wang Y, Chen P, Sarav M, Haas M, Minto A, Petkova M, Quigg R. Mesangial cell complement receptor 1‐related protein y limits complement‐dependent neutrophil accumulation in immune complex glomerulonephritis. Immunology 2009, 128: e895-e904. PMID: 19740350, PMCID: PMC2753953, DOI: 10.1111/j.1365-2567.2009.03102.x.Peer-Reviewed Original ResearchConceptsWild-type miceImmune complex glomerulonephritisCrry(-/-Complement receptor 1Weeks of immunizationNeutrophil infiltrationExpression of decay-accelerating factorMouse kidneyAlpha-smooth muscle actinLimits complement activationSerum C3 levelsImmune complex depositionProliferating cell nuclear antigenPathogenesis of immune complex glomerulonephritisCell nuclear antigenMesangial cell proliferationDecay-accelerating factorAbsent stainingRenal expressionC3 levelsProliferative GNNeutrophil recruitmentGlomerular hypercellularityNeutrophil accumulationLevels several-fold