Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG
Sarav M, Wang Y, Hack B, Chang A, Jensen M, Bao L, Quigg R. Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG. Journal Of The American Society Of Nephrology 2009, 20: 1941-1952. PMID: 19661163, PMCID: PMC2736763, DOI: 10.1681/asn.2008090976.Peer-Reviewed Original ResearchConceptsElimination of IgGFcRn(-/-Renal lossFcRn(-/-) miceMinimal urinary excretionSerum albumin levelWild-type miceWild-type kidneysSerum concentrations of albuminProximal tubular epitheliumWild-type controlsDevelopment of hypoalbuminemiaNeonatal Fc receptorLoss of IgGLoss of albuminSerum levelsAlbumin levelsIncreased to wild-type levelsUrinary excretionSerum concentrationsFc receptorsTubular epitheliumConcentrations of albuminPlasma protein poolKidneyMesangial cell complement receptor 1‐related protein y limits complement‐dependent neutrophil accumulation in immune complex glomerulonephritis
Bao L, Wang Y, Chen P, Sarav M, Haas M, Minto A, Petkova M, Quigg R. Mesangial cell complement receptor 1‐related protein y limits complement‐dependent neutrophil accumulation in immune complex glomerulonephritis. Immunology 2009, 128: e895-e904. PMID: 19740350, PMCID: PMC2753953, DOI: 10.1111/j.1365-2567.2009.03102.x.Peer-Reviewed Original ResearchConceptsWild-type miceImmune complex glomerulonephritisCrry(-/-Complement receptor 1Weeks of immunizationNeutrophil infiltrationExpression of decay-accelerating factorMouse kidneyAlpha-smooth muscle actinLimits complement activationSerum C3 levelsImmune complex depositionProliferating cell nuclear antigenPathogenesis of immune complex glomerulonephritisCell nuclear antigenMesangial cell proliferationDecay-accelerating factorAbsent stainingRenal expressionC3 levelsProliferative GNNeutrophil recruitmentGlomerular hypercellularityNeutrophil accumulationLevels several-fold