Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG
Sarav M, Wang Y, Hack B, Chang A, Jensen M, Bao L, Quigg R. Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG. Journal Of The American Society Of Nephrology 2009, 20: 1941-1952. PMID: 19661163, PMCID: PMC2736763, DOI: 10.1681/asn.2008090976.Peer-Reviewed Original ResearchConceptsElimination of IgGFcRn(-/-Renal lossFcRn(-/-) miceMinimal urinary excretionSerum albumin levelWild-type miceWild-type kidneysSerum concentrations of albuminProximal tubular epitheliumWild-type controlsDevelopment of hypoalbuminemiaNeonatal Fc receptorLoss of IgGLoss of albuminSerum levelsAlbumin levelsIncreased to wild-type levelsUrinary excretionSerum concentrationsFc receptorsTubular epitheliumConcentrations of albuminPlasma protein poolKidney