Featured Publications
Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement
Knauert M, Ayas N, Bosma K, Drouot X, Heavner M, Owens R, Watson P, Wilcox M, Anderson B, Cordoza M, Devlin J, Elliott R, Gehlbach B, Girard T, Kamdar B, Korwin A, Lusczek E, Parthasarathy S, Spies C, Sunderram J, Telias I, Weinhouse G, Zee P. Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement. American Journal Of Respiratory And Critical Care Medicine 2023, 207: e49-e68. PMID: 36999950, PMCID: PMC10111990, DOI: 10.1164/rccm.202301-0184st.Peer-Reviewed Original ResearchMorning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea.
Knauert M, Adekolu O, Xu Z, Deng A, Chu J, Baldassarri S, Kushida C, Yaggi H, Zinchuk A. Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2023, 20: 1182-1191. PMID: 36917194, PMCID: PMC10405611, DOI: 10.1513/annalsats.202210-885oc.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaCPAP adherenceMorning chronotypeCPAP useSleep apneaClinical trialsMorningness-Eveningness QuestionnaireSleep durationContinuous positive airway pressure therapyPositive airway pressure therapyContinuous positive airway pressureSevere obstructive sleep apneaChronotype of patientsDaily CPAP useAirway pressure therapyPositive airway pressureShort sleep durationCPAP armAirway pressureObese menPressure therapyPoor adherenceWeekend catchAdherence dataEvening chronotypeKeeping an eye on circadian time in clinical research and medicine
Klerman E, Brager A, Carskadon M, Depner C, Foster R, Goel N, Harrington M, Holloway P, Knauert M, LeBourgeois M, Lipton J, Merrow M, Montagnese S, Ning M, Ray D, Scheer F, Shea S, Skene D, Spies C, Staels B, St‐Onge M, Tiedt S, Zee P, Burgess H. Keeping an eye on circadian time in clinical research and medicine. Clinical And Translational Medicine 2022, 12: e1131. PMID: 36567263, PMCID: PMC9790849, DOI: 10.1002/ctm2.1131.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2024
Feeding critically ill patients at the right time of day
Dashti H, Wang Y, Knauert M. Feeding critically ill patients at the right time of day. Critical Care 2024, 28: 206. PMID: 38915028, PMCID: PMC11197374, DOI: 10.1186/s13054-024-04994-0.Peer-Reviewed Original ResearchEarly goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study
Powierza C, Doyle M, Wasden K, Intihar T, Korwin A, Honiden S, Knauert M. Early goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study. BMJ Open Respiratory Research 2024, 11: e001962. PMID: 38749534, PMCID: PMC11097881, DOI: 10.1136/bmjresp-2023-001962.Peer-Reviewed Original ResearchConceptsEarly enteral nutritionIn-hospital deathCritically ill adultsRetrospective cohort studyDays of intubationEnteral nutritionIll adultsAdult patientsCohort studyAssociated with decreased in-hospital deathsMechanically ventilated critically ill adultsGoal enteral nutritionIncreased hospital dischargeInitiation of ENCritically ill adult patientsMechanically ventilated adult patientsIncidence of in-hospital deathMedical intensive care unitAssociated with significant improvementsIll adult patientsDose of ENIntensive care unitClinical outcomesImprove mortalityPrimary outcome0230 Comparing Subjective and Objective Measures of Chronotypes and Their Associations with Age in Older Adults
Pan Y, Cho G, Burzynski C, Polisetty L, Doyle M, Iannone L, Knauert M, Yaggi H, Gill T, Miner B. 0230 Comparing Subjective and Objective Measures of Chronotypes and Their Associations with Age in Older Adults. Sleep 2024, 47: a99-a99. DOI: 10.1093/sleep/zsae067.0230.Peer-Reviewed Original ResearchOlder adultsAssociated with ageCommunity-living older adultsSleep midpointSeven-daySelf-reported sleep complaintsDays of actigraphyChi-square testTwo-sample t-testActivity countsNo significant differencePearson correlation coefficientAdverse outcomesCT groupMinority raceVariability of chronotypeAdvanced ageObservational studyMorningness-Eveningness QuestionnaireMeasures of chronotypeDemographic factorsSleep onsetModerate correlationSleep disturbanceSignificant difference0309 Concordance in Electroencephalography-Headband versus Polysomnography by Demographics and Cognitive Status
Miner B, Pan Y, Cho G, Burzynski C, Polisetty L, Doyle M, Iannone L, Knauert M, Gill T, Yaggi H. 0309 Concordance in Electroencephalography-Headband versus Polysomnography by Demographics and Cognitive Status. Sleep 2024, 47: a133-a133. DOI: 10.1093/sleep/zsae067.0309.Peer-Reviewed Original ResearchTotal sleep timeIntraclass correlation coefficientMeasure total sleep timeMild cognitive impairmentCognitive statusSleep complaintsNight of home-based polysomnographyHome-based polysomnographySelf-reported sleep complaintsCommunity-living older adultsBetween-group differencesPaired t-testPresence of mild cognitive impairmentExcellent concordanceSleep timeAcceptable alternativeWASOPolysomnographyReduced concordancePSGSleep disturbanceOlder personsOlder adultsPeople of colorWomen0757 Association of Insomnia with Objective Short Sleep Duration and Other Phenotypes with Mortality in Older Persons
Miner B, Pan Y, Cho G, Knauert M, Yaggi H, Gill T, Stone K, Ensrud K, Zeitzer J, Yaffe K, Doyle M. 0757 Association of Insomnia with Objective Short Sleep Duration and Other Phenotypes with Mortality in Older Persons. Sleep 2024, 47: a324-a325. DOI: 10.1093/sleep/zsae067.0757.Peer-Reviewed Original ResearchAssociated with increased mortality riskAssociation of insomniaMortality riskOlder personsShort sleep durationOsteoporotic fracturesAdjusted modelsStudy of Osteoporotic FracturesSleep durationHigher mortality riskCox proportional hazards modelsMen Sleep StudyNormal sleepProportional hazards modelAssociated with mortalitySevere sleep-disordered breathingUnadjusted modelsUnadjusted analysisCausal pathwaysSleep-disordered breathingFollow-up timePrevalence ratesReference groupHazards modelRisk phenotypes0680 Body Clock and Aging: Relationships of Circadian Rhythm with Sleep Quality, Mental Health and Geriatric Conditions
Adirim Z, Pan Y, Doyle M, Knauert M, Yaggi H, Miner B. 0680 Body Clock and Aging: Relationships of Circadian Rhythm with Sleep Quality, Mental Health and Geriatric Conditions. Sleep 2024, 47: a291-a291. DOI: 10.1093/sleep/zsae067.0680.Peer-Reviewed Original ResearchOlder adult populationMental healthGeriatric conditionsSleep midpointSleep qualityAssociated with cognitive dysfunctionOlder adultsAdult populationAssociated with mental health diagnosesCommunity-dwelling older adultsAssociated with lower cognitive scoresMental health diagnosesAssociated with sleep qualityMental health conditionsSubjective sleep qualityReduced total sleep timeLower cognitive scoresCross-sectional studyGeneral adult populationPsychiatric symptomsTotal sleep timeSelf-reported sleep complaintsCognitive dysfunctionCircadian rhythmLater sleep midpointIntensive care unit interventions to promote sleep and circadian biology in reducing incident delirium: a scoping review
Wilcox M, Burry L, Englesakis M, Coman B, Daou M, van Haren F, Ely E, Bosma K, Knauert M. Intensive care unit interventions to promote sleep and circadian biology in reducing incident delirium: a scoping review. Thorax 2024, thorax-2023-220036. PMID: 38350730, DOI: 10.1136/thorax-2023-220036.Peer-Reviewed Original ResearchSeverity of deliriumIntensive care unitIncident deliriumCare bundleReducing incident deliriumSensitive search of electronic databasesSearch of electronic databasesEnglish-language studiesPromote sleepPromotion interventionsEvaluate interventionsIntensive care unit interventionsElectronic databasesNon-pharmacologicalInclusion criteriaIntervention strategiesDeliriumInterventionCare unitEye maskConference proceedingsVariable reportingSleepPharmacological interventionsAssociation
2023
Consecutive Inpatient Hematology Consultation Service Utilization across 11 Years in the Medical Intensive Care Unit
Allen C, Streiff M, Naik R, Knauert M, Goshua G. Consecutive Inpatient Hematology Consultation Service Utilization across 11 Years in the Medical Intensive Care Unit. Blood 2023, 142: 2323. DOI: 10.1182/blood-2023-184891.Peer-Reviewed Original ResearchMedical intensive care unitIntensive care unitHematology consultationCare unitHematology consultMICU admissionLymphoproliferative disordersHematologic malignanciesMalignant hematologyService utilizationConsecutive patients 18 yearsHospital discharge statusPatients 18 yearsCritical care managementRetrospective observational studySingle academic centerPlasma cell dyscrasiaQuality improvement metricsDay of consultationHigh clinical volumeService needsDescriptive statisticsExpedient careICU consultationBaseline demographics0726 Agreement Between an Electroencephalography-Measuring Headband and Polysomnography in Older Adults with Sleep Disturbances
Miner B, Pan Y, Burzynski C, Iannone L, Knauert M, Gill T, Yaggi H. 0726 Agreement Between an Electroencephalography-Measuring Headband and Polysomnography in Older Adults with Sleep Disturbances. Sleep 2023, 46: a319-a320. DOI: 10.1093/sleep/zsad077.0726.Peer-Reviewed Original Research0733 The Association of Nocturia and Napping with Obstructive Sleep Apnea Among Older Adults with Insomnia and/or Daytime Sleepiness
Polisetty L, Pan Y, Iannone L, Knauert M, Yaggi K, Gill T, Miner B. 0733 The Association of Nocturia and Napping with Obstructive Sleep Apnea Among Older Adults with Insomnia and/or Daytime Sleepiness. Sleep 2023, 46: a322-a323. DOI: 10.1093/sleep/zsad077.0733.Peer-Reviewed Original ResearchApnea-hypopnea indexObstructive sleep apneaAssociation of nocturiaMinutes/weekDaytime sleepinessNap durationOlder adultsSleep apneaClaude D. Pepper Older Americans Independence CenterIntroduction Obstructive sleep apneaMean apnea-hypopnea indexHigher apnea-hypopnea indexCommunity-dwelling older adultsSymptoms of nocturiaCommunity-Living AdultsIdentification of OSAEvents/hrSelf-reported average numberHome-based polysomnographySymptoms of insomniaSelf-reported numberMore nocturiaHypopnea indexMean ageNocturia0841 Feasibility of Actigraphy during a Daytime Bright Pilot Study in the Medical ICU
Lukas M, Doyle M, Intihar T, Wright K, Redeker N, Pisani M, Yaggi H, Knauert M. 0841 Feasibility of Actigraphy during a Daytime Bright Pilot Study in the Medical ICU. Sleep 2023, 46: a370-a371. DOI: 10.1093/sleep/zsad077.0841.Peer-Reviewed Original ResearchRest-activity patternsCircadian quotientMICU patientsPilot studyCosinor analysisStudy days 1Illness severity scoresCritical illnessMedical ICUMethods PatientsOngoing RCTsMean ageSeverity scorePatient outcomesActigraphy recordingsPatientsDay 1Patient careCircadian disruptionResults ThirteenActigraphyTotal recordingCircadian alignmentCircadian misalignmentMesor0842 Feasibility of daytime bright light exposure and urinary 6-sulfatoxymelatonin profiling in the medical ICU: A pilot study
Intihar T, Doyle M, Lukas M, Wright K, Redeker N, Pisani M, Yaggi H, Knauert M. 0842 Feasibility of daytime bright light exposure and urinary 6-sulfatoxymelatonin profiling in the medical ICU: A pilot study. Sleep 2023, 46: a371-a371. DOI: 10.1093/sleep/zsad077.0842.Peer-Reviewed Original ResearchMedical intensive care unitMICU patientsDaytime bright light exposureStudy days 1Intensive care unitIllness severity scoresBright light exposureWarrants further investigationCircadian outcomesMedical ICUCritical illnessIll patientsOngoing RCTsCare unitCircadian timingMean ageMelatonin useCircadian phaseSeverity scorePilot trialSufficient urinePatientsStudy daysBright lightDay 10846 Prevalence of Obstructive Sleep Apnea Among Medical ICU Patients
Ehrenberg M, Kongpakpaisarn K, Intihar T, Doyle M, Knauert M. 0846 Prevalence of Obstructive Sleep Apnea Among Medical ICU Patients. Sleep 2023, 46: a373-a373. DOI: 10.1093/sleep/zsad077.0846.Peer-Reviewed Original ResearchPre-existing OSAObstructive sleep apneaHigh clinical suspicionMICU patientsOSA diagnosisClinical suspicionSleep apneaMedical intensive care unit patientsSeverity of OSAIntensive care unit patientsAcute respiratory failureMedical ICU patientsProspective observational studyCare unit patientsPast medical historyAPACHE II severityBody mass indexElectronic medical recordsRespiratory failureChart reviewClinical characteristicsICU populationOSA patientsPatient demographicsUnit patients
2022
Insomnia with objective short sleep duration in community‐living older persons: A multifactorial geriatric health condition
Miner B, Doyle M, Knauert M, Yaggi H, Stone K, Ancoli‐Israel S, Cauley J, Redline S, Blackwell T, Gill T, Groups F. Insomnia with objective short sleep duration in community‐living older persons: A multifactorial geriatric health condition. Journal Of The American Geriatrics Society 2022, 71: 1198-1208. PMID: 36524599, PMCID: PMC10089942, DOI: 10.1111/jgs.18195.Peer-Reviewed Original ResearchConceptsShort sleep durationObjective short sleep durationCommunity-living older personsSleep durationOsteoporotic fracturesOlder menCommunity-living older menOlder personsMultiple predisposingHealth conditionsMen Sleep StudyModifiable risk factorsSeparate logistic regression modelsPoor sleep qualityHigh-risk phenotypeCross-sectional studyCross-sectional associationsMiddle-aged personsLogistic regression modelsClinical correlatesRisk factorsMultivariable modelSleep studiesSleep qualityOlder womenINFLUENCE OF DEMOGRAPHIC FACTORS ON RESEARCH PARTICIPATION
SAMOJEDNY V, INTIHAR T, KNAUERT M. INFLUENCE OF DEMOGRAPHIC FACTORS ON RESEARCH PARTICIPATION. CHEST Journal 2022, 162: a1479. DOI: 10.1016/j.chest.2022.08.1246.Peer-Reviewed Original ResearchSleep in Critical Illness: Future Directions
Knauert M, Parthasarathy S. Sleep in Critical Illness: Future Directions. 2022, 291-309. DOI: 10.1007/978-3-031-06447-0_17.ChaptersIntensive care unitCritical illnessSleep disruptionSleep promotionCircadian disruptionAcute illness factorsCritical care outcomesCritical illness outcomesAspects of sleepICU sleepCare unitICU cliniciansIllness factorsPatient outcomesMethodologic limitationsIllness outcomesSleep interventionsCare outcomesClinical practiceSleep measuresSleep deficiencyNatural historyLimited evidenceSleepIllnessBest Practice for Improving Sleep in the ICU. Part I: Non-pharmacologic
Korwin A, Knauert M. Best Practice for Improving Sleep in the ICU. Part I: Non-pharmacologic. 2022, 231-248. DOI: 10.1007/978-3-031-06447-0_14.ChaptersIntensive care unitICU patientsNormal sleepCritical care treatmentNon-pharmacologic therapiesNon-pharmacologic interventionsMost ICU patientsAbnormal circadian rhythmPoor quality sleepCircadian functionAcute illnessCritical illnessPatient characteristicsIll adultsCare unitChronotherapeutic interventionsCare treatmentSleep preferenceCurrent evidencePatient careCircadian disruptionSleepPatientsFuture interventionsPractice change