2024
Long-Term Use of Muscle Relaxant Medications for Chronic Pain
Oldfield B, Gleeson B, Morford K, Adams Z, Funaro M, Becker W, Merlin J. Long-Term Use of Muscle Relaxant Medications for Chronic Pain. JAMA Network Open 2024, 7: e2434835. PMID: 39298168, PMCID: PMC11413720, DOI: 10.1001/jamanetworkopen.2024.34835.Peer-Reviewed Original ResearchConceptsLow back painBack painSkeletal muscle relaxantsChronic painRandomized clinical trialsNeck painCohort studyEfficacy of long-term useLong-term useSystematically searched Ovid MEDLINEMuscle relaxant medicationsModerate risk of biasOpioid prescribing guidelinesRisk of biasQuality of cohort studiesWeb of SciencePainful crampsRelaxant medicationsChronic pain syndromesPainful spasmsOvid MEDLINEPrescribing guidelinesSystematic reviewIncreased prescriptionModerate riskPrehospital use of point-of-care tests by community health workers: a scoping review
Ebbs D, Taricia M, Funaro M, O’Daniel M, Cappello M. Prehospital use of point-of-care tests by community health workers: a scoping review. Frontiers In Public Health 2024, 12: 1360322. PMID: 38721545, PMCID: PMC11076783, DOI: 10.3389/fpubh.2024.1360322.Peer-Reviewed Original ResearchConceptsCommunity health workersHealth workersPoint-of-care testingPrehospital settingLocal community health workersFull-text reviewMedical Subject HeadingsPRISMA extensionPrehospital useImplementation strategiesResource settingsEarly risk stratificationMedical librariansStudy criteriaSubject headingsPoint-of-carePrehospitalRisk stratificationWorkersCommunitySetsReviewPRISMAHIVMalariaNeural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis
Ibrahim K, Iturmendi-Sabater I, Vasishth M, Barron D, Guardavaccaro M, Funaro M, Holmes A, McCarthy G, Eickhoff S, Sukhodolsky D. Neural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis. Schizophrenia Research 2024, 264: 298-313. PMID: 38215566, PMCID: PMC10922721, DOI: 10.1016/j.schres.2023.12.003.Peer-Reviewed Original ResearchConceptsRight inferior frontal gyrusAutism spectrum disorderInferior frontal gyrusEye gaze processingActivation likelihood estimationRight fusiform gyrusGaze processingFrontal gyrusFusiform gyrusFrontotemporal circuitryFunctional decodingSpectrum disorderActivation likelihood estimation meta-analysisMeta-analytic connectivity modelingMeta-analytic connectivityNeural circuit disruptionsTransdiagnostic biomarkerEmotional processingLeft amygdalaNeurobiological dysfunctionSocial cognitionEmotion perceptionNeural mechanismsSchizophreniaSpatial cognition
2023
Common Pathways of Epileptogenesis in Patients With Epilepsy Post–Brain Injury
Misra S, Khan E, Lam T, Mazumder R, Gururangan K, Hickman L, Goswami V, Funaro M, Eldem E, Sansing L, Sico J, Quinn T, Liebeskind D, Montaner J, Kwan P, Mishra N. Common Pathways of Epileptogenesis in Patients With Epilepsy Post–Brain Injury. Neurology 2023, 101: e2243-e2256. PMID: 37550071, PMCID: PMC10727219, DOI: 10.1212/wnl.0000000000207749.Peer-Reviewed Original ResearchConceptsStandardized mean differencePoststroke epilepsyBrain injuryGenetic susceptibilityDisparate time pointsRisk of epileptogenesisLate-onset seizuresDevelopment of epilepsyBlood glucose levelsTraumatic brain injuryMean biomarker levelsIndividual genetic susceptibilityWeb of ScienceReported biomarkersPrimary outcomeEpileptogenic processBiofluid biomarkersBias assessmentBiomarker levelsCommon biological pathwaysEnrichment analysisGlucose levelsHigh riskPrognostic studiesEpilepsyClinical characteristics and outcomes of patients with post-stroke epilepsy: protocol for an individual patient data meta-analysis from the International Post-stroke Epilepsy Research Repository (IPSERR)
Mishra N, Kwan P, Tanaka T, Sunnerhagen K, Dawson J, Zhao Y, Misra S, Wang S, Sharma V, Mazumder R, Funaro M, Ihara M, Nicolo J, Liebeskind D, Yasuda C, Cendes F, Quinn T, Ge Z, Scalzo F, Zelano J, Kasner S, Consortium I, Mishra N, Kwan P, Friedman A, Engel J. Clinical characteristics and outcomes of patients with post-stroke epilepsy: protocol for an individual patient data meta-analysis from the International Post-stroke Epilepsy Research Repository (IPSERR). BMJ Open 2023, 13: e078684. PMID: 37968000, PMCID: PMC10660442, DOI: 10.1136/bmjopen-2023-078684.Peer-Reviewed Original ResearchConceptsPost-stroke epilepsyPost-stroke seizuresIndividual patient dataClinical characteristicsLate post-stroke seizuresPatient dataOutcomes of patientsFuture clinical trialsPatient outcome measuresComprehensive search strategyAcute strokePeer-reviewed journalsStroke patientsPrognostic valueStroke mortalityBias assessmentClinical trialsObservational studyOutcome measuresLanguage of publicationEpileptic seizuresPatientsEthics approvalStudy authorsIPD-MAOutcomes in Patients With Poststroke Seizures
Misra S, Kasner S, Dawson J, Tanaka T, Zhao Y, Zaveri H, Eldem E, Vazquez J, Silva L, Mohidat S, Hickman L, Khan E, Funaro M, Nicolo J, Mazumder R, Yasuda C, Sunnerhagen K, Ihara M, Ross J, Liebeskind D, Kwan P, Quinn T, Engel J, Mishra N. Outcomes in Patients With Poststroke Seizures. JAMA Neurology 2023, 80: 1155-1165. PMID: 37721736, PMCID: PMC10507596, DOI: 10.1001/jamaneurol.2023.3240.Peer-Reviewed Original ResearchConceptsPoststroke seizuresPoor functional outcomeLate seizuresEarly seizuresStroke subtypesFunctional outcomeOdds ratioSystematic reviewJoanna Briggs Institute toolsHemorrhagic stroke subtypesOutcomes of patientsHistory of strokeTrials of interventionsRisk of biasMeta-Analyses (PRISMA) checklistPreferred Reporting ItemsMeta-regression analysisWeb of ScienceRecurrent strokeGreater disabilityPoor outcomeDementia riskSubgroup analysisBias assessmentEgger's testThe state of evidence for social and emotional learning: A contemporary meta‐analysis of universal school‐based SEL interventions
Cipriano C, Strambler M, Naples L, Ha C, Kirk M, Wood M, Sehgal K, Zieher A, Eveleigh A, McCarthy M, Funaro M, Ponnock A, Chow J, Durlak J. The state of evidence for social and emotional learning: A contemporary meta‐analysis of universal school‐based SEL interventions. Child Development 2023, 94: 1181-1204. PMID: 37448158, DOI: 10.1111/cdev.13968.Peer-Reviewed Original ResearchConceptsSEL interventionsSchool-based SEL interventionsEmotional learning interventionSEL researchSchool climateStudent experienceSEL contentAcademic achievementLearning interventionEmotional learningImplementation qualitySchool functioningStudentsPeer relationshipsIntervention featuresState of evidenceKindergartenLearningSkillsAchievementAttitudesExperienceGradePracticeInterventionHow do smoking, vaping, and nicotine affect people with epilepsy and seizures? A scoping review protocol
Narrett J, Khan W, Funaro M, Moeller J. How do smoking, vaping, and nicotine affect people with epilepsy and seizures? A scoping review protocol. PLOS ONE 2023, 18: e0288120. PMID: 37418386, PMCID: PMC10328254, DOI: 10.1371/journal.pone.0288120.Peer-Reviewed Original ResearchConceptsSmoking cessationTobacco useReview protocolBurden of comorbiditiesType of epilepsyJoanna Briggs Institute ManualPopulation of personsPeer-reviewed journalsSeizure frequencyNicotine replacementControl seizuresPreventable deathsSide effectsSmokingEthical approvalEpilepsyHealth outcomesPrevalent diseaseSeizuresPersonalized careDirect further researchEvidence synthesisMajor causeSystematic screeningAPA PsycInfoLessons learned and future directions: A scoping review of American Indian and Alaska Native participants in the National Drug Abuse Treatment Clinical Trials Network
Crouch M, Venner K, Wendt D, Burlew A, Baukol P, Funaro M, Sorrell T, Haeny A. Lessons learned and future directions: A scoping review of American Indian and Alaska Native participants in the National Drug Abuse Treatment Clinical Trials Network. Journal Of Substance Use And Addiction Treatment 2023, 153: 209081. PMID: 37230391, PMCID: PMC10529616, DOI: 10.1016/j.josat.2023.209081.Peer-Reviewed Original ResearchWeight change among patients engaged in medication treatment for opioid use disorder: a scoping review
Carr M, Lou R, Macdonald-Gagnon G, Peltier M, Funaro M, Martino S, Masheb R. Weight change among patients engaged in medication treatment for opioid use disorder: a scoping review. The American Journal Of Drug And Alcohol Abuse 2023, 49: 551-565. PMID: 37200510, PMCID: PMC10840392, DOI: 10.1080/00952990.2023.2207720.Peer-Reviewed Original ResearchConceptsOpioid use disorderExcess weight gainWeight gainMedication treatmentUse disordersType of MOUDBuprenorphine/naloxoneRetrospective chart reviewUse of methadoneBody mass indexModerate weight gainMOUD initiationChart reviewCohort studyOpioid useBuprenorphine/Mass indexMedication doseMethadone treatmentNonrandomized studyCase reportEthnic disparitiesPotential associationMOUDPatientsDoes This Child With High Blood Pressure Have Secondary Hypertension?
Nugent J, Jiang K, Funaro M, Saran I, Young C, Ghazi L, Bakhoum C, Wilson F, Greenberg J. Does This Child With High Blood Pressure Have Secondary Hypertension? JAMA 2023, 329: 1012-1021. PMID: 36976276, DOI: 10.1001/jama.2023.3184.Peer-Reviewed Original ResearchConceptsBlood pressure loadAmbulatory blood pressure monitoringSecondary hypertensionBlood pressure monitoringPrimary hypertensionFamily historyBlood pressurePressure monitoringDiastolic blood pressure loadSystolic blood pressure loadSerum uric acid concentrationAmbulatory blood pressureHigh blood pressureHistory of prematurityPrimary care clinicsRisk of biasNumber of patientsDatabases of MEDLINEDiagnostic Accuracy Studies toolLower body weightRandom-effects modelingUric acid concentrationWeb of ScienceLikelihood ratioAsymptomatic presentationEvaluating the validity of game-based assessments measuring cognitive function among children and adolescents: A systematic review and meta-analysis
Aneni K, Gomati de la Vega I, Jiao M, Funaro M, Fiellin L. Evaluating the validity of game-based assessments measuring cognitive function among children and adolescents: A systematic review and meta-analysis. Progress In Brain Research 2023, 279: 1-36. PMID: 37661161, DOI: 10.1016/bs.pbr.2023.02.002.Peer-Reviewed Original Research
2022
Multidimensional assessment of access to medications for opioid use disorder across urban and rural communities: A scoping review
Bommersbach T, Justen M, Bunting A, Funaro M, Winstanley E, Joudrey P. Multidimensional assessment of access to medications for opioid use disorder across urban and rural communities: A scoping review. International Journal Of Drug Policy 2022, 112: 103931. PMID: 36563489, DOI: 10.1016/j.drugpo.2022.103931.Peer-Reviewed Original ResearchConceptsOpioid use disorderMOUD accessUse disordersPatient's perspectiveMajority of patientsTailoring of interventionsPatient-centered accessMOUD deliveryTreatment outcomesInclusion criteriaPatient's abilityMOUD servicesDimensions of accessElectronic databasesStudy characteristicsQualitative synthesisUnique articlesRural communitiesStudy sampleHealthcare systemCommunity-engaged researchAccess dimensionsMedicationsDisordersCOVID-19Machine Learning and Non-Affective Psychosis: Identification, Differential Diagnosis, and Treatment
Ferrara M, Franchini G, Funaro M, Cutroni M, Valier B, Toffanin T, Palagini L, Zerbinati L, Folesani F, Murri M, Caruso R, Grassi L. Machine Learning and Non-Affective Psychosis: Identification, Differential Diagnosis, and Treatment. Current Psychiatry Reports 2022, 24: 925-936. PMID: 36399236, PMCID: PMC9780131, DOI: 10.1007/s11920-022-01399-0.Peer-Reviewed Original ResearchConceptsMachine learning techniquesBinary classification caseSetting of hyperparametersSupport vector machineArtificial intelligenceLearning techniquesMachine learningML applicationsElectronic health recordsDigital contentML toolsSupervised approachClassification casesVector machineRandom forestGradient boostingML approachHealth recordsIllness detectionOverall performancePromising resultsSources of dataIdentification toolToolPreprocessingExamining weight bias before and/or after bariatric surgery: A systematic review
Bennett BL, Lawson JL, Funaro MC, Ivezaj V. Examining weight bias before and/or after bariatric surgery: A systematic review. Obesity Reviews 2022, 23: e13500. PMID: 36053042, DOI: 10.1111/obr.13500.Peer-Reviewed Original ResearchConceptsBariatric surgeryWeight biasPeer-reviewed quantitative studiesRisk of biasBariatric populationMedical sequelaeHigh riskSurgeryBehavioral sequelaeSystematic reviewFuture patientsGreater riskWeight stigmaSequelaePatientsRiskSample of individualsPresent studyMost studiesNegative correlatesRigorous researchReviewStudyCurrent status of clinical outcome measures in inclusion body myositis: a systematised review.
Roy B, Lucchini M, Lilleker J, Goyal N, Naddaf E, Adler B, Alfano L, Malandraki G, Focht Garand K, Mochel D, Badrising U, Machado P, Pagkatipunan R, Ramdharry G, Wang L, Funaro M, Schmidt J, Kushlaf H, Schiopu E, Stipancic K, Goyal N, d'Alessandro M, Conticini E, Cruz-Coble B, Lloyd T. Current status of clinical outcome measures in inclusion body myositis: a systematised review. Clinical And Experimental Rheumatology 2022, 41: 370-378. PMID: 36762744, DOI: 10.55563/clinexprheumatol/ifacv3.Peer-Reviewed Original ResearchConceptsIBM functional rating scaleInclusion body myositisIdiopathic inflammatory myopathiesOutcome measuresClinical studiesBody myositisMuscle testingClinical trialsMaximal voluntary isometric contraction testingOpen-label clinical trialSix-minute walk distanceSporadic inclusion body myositisQuantitative muscle testingSecondary outcome measuresManual muscle testingPrimary outcome measureClinical outcome measuresCore set measuresNew potential therapeuticsSuitable outcome measuresThigh muscle volumeDifferent outcome measuresInflammatory myopathiesWalk distancePharmacological therapyRacial and ethnic differences in alcohol, cannabis, and illicit substance use treatment: a systematic review and narrative synthesis of studies done in the USA
Jordan A, Quainoo S, Nich C, Babuscio TA, Funaro MC, Carroll KM. Racial and ethnic differences in alcohol, cannabis, and illicit substance use treatment: a systematic review and narrative synthesis of studies done in the USA. The Lancet Psychiatry 2022, 9: 660-675. PMID: 35752192, DOI: 10.1016/s2215-0366(22)00160-2.Peer-Reviewed Original ResearchConceptsSubstance use outcomesTreatment initiationJoanna Briggs Institute appraisal toolsSystematic reviewSubstance use disordersSignificant differencesSubstance use treatmentDissemination of treatmentUncontrolled trialsClinical trialsBaseline differencesStudy qualityInclusion criteriaUse disordersRCTsNarrative synthesisSocial determinantsUse treatmentAppraisal toolLatinx adultsEthnic differencesEthnic populationsOutcomesTrialsLatinx populationsEvidence-based service delivery interventions for testing, linking, treating, and retaining children and adolescents living with HIV in primary health care settings: Protocol for a systematic review
Putta N, Hansen CE, Funaro MC, Campbell M, Essajee S, Mbori-Ngacha D, Frimpong S, Wang SY, Paintsil E. Evidence-based service delivery interventions for testing, linking, treating, and retaining children and adolescents living with HIV in primary health care settings: Protocol for a systematic review. PLOS ONE 2022, 17: e0269063. PMID: 35709211, PMCID: PMC9202933, DOI: 10.1371/journal.pone.0269063.Peer-Reviewed Original ResearchConceptsSystematic reviewPrimary health care settingsService delivery interventionsMeta-analysis protocolPairs of reviewersHealth care providersEvidence-based service deliveryPreferred Reporting ItemsHealth care settingsRandom-effects modelComprehensive search strategyImmunologic outcomesPregnant womenCochrane LibraryTreatment optionsDelivery interventionsRetention of childrenInclusion criteriaCare settingsCare providersHIVRegistration numberReporting ItemsCare deliveryNarrative synthesisAn umbrella review on the use of antipsychotics in anxiety disorders: A registered report protocol
Garakani A, Freire RC, Buono FD, Thom RP, Larkin K, Funaro MC, Salehi M, Perez-Rodriguez MM. An umbrella review on the use of antipsychotics in anxiety disorders: A registered report protocol. PLOS ONE 2022, 17: e0269772. PMID: 35709149, PMCID: PMC9202921, DOI: 10.1371/journal.pone.0269772.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSelective serotonin reuptake inhibitorsSerotonin-norepinephrine reuptake inhibitorsUse of antipsychoticsLong-term riskAnxiety disordersReuptake inhibitorsUmbrella reviewSide effectsPanic disorderSystematic reviewNon-antipsychotic medicationsUse of quetiapineFirst-line treatmentSerotonin reuptake inhibitorsNorepinephrine reuptake inhibitorsEvidence of efficacyCommon psychiatric disordersTraditional pharmacologic treatmentTreatment of anxietyAdjunctive treatmentPharmacologic treatmentTricyclic antidepressantsAntipsychoticsPsychiatric disordersSocial anxiety disorderGenerativity Among Persons Providing or Receiving Peer or Mutual Support: A Scoping Review
Jordan G, Grazioplene R, Florence A, Hammer P, Funaro MC, Davidson L, Bellamy CD. Generativity Among Persons Providing or Receiving Peer or Mutual Support: A Scoping Review. Psychiatric Rehabilitation Journal 2022, 45: 123-135. PMID: 34618488, DOI: 10.1037/prj0000498.Peer-Reviewed Original Research