2008
The effects of ramelteon on respiration during sleep in subjects with moderate to severe chronic obstructive pulmonary disease
Kryger M, Roth T, Wang-Weigand S, Zhang J. The effects of ramelteon on respiration during sleep in subjects with moderate to severe chronic obstructive pulmonary disease. Sleep And Breathing 2008, 13: 79-84. PMID: 18584227, DOI: 10.1007/s11325-008-0196-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultComorbidityCross-Over StudiesDouble-Blind MethodFemaleHumansIndenesMaleOximetryPolysomnographyPulmonary Disease, Chronic ObstructiveReceptors, MelatoninSeverity of Illness IndexSleep Apnea SyndromesSleep Apnea, ObstructiveSleep Initiation and Maintenance DisordersSleep StagesYoung AdultConceptsSevere chronic obstructive pulmonary diseaseChronic obstructive pulmonary diseaseEffects of ramelteonObstructive pulmonary diseasePulmonary diseaseMean SaO2Respiratory depressant effectsApnea-hypopnea indexPoor sleep qualityTotal sleep timeMelatonin receptor agonistResultsNo significant differencesSignificant differencesAbnormal breathing eventsRamelteon 8Primary endpointAdverse eventsPersistent sleepCrossover studyDepressant effectPolysomnographic monitoringReceptor agonistRespiratory effortInsomnia treatmentSleep quality
2006
Gender differences on polysomnographic findings in Greek subjects with obstructive sleep apnea syndrome
Vagiakis E, Kapsimalis F, Lagogianni I, Perraki H, Minaritzoglou A, Alexandropoulou K, Roussos C, Kryger M. Gender differences on polysomnographic findings in Greek subjects with obstructive sleep apnea syndrome. Sleep Medicine 2006, 7: 424-430. PMID: 16740405, DOI: 10.1016/j.sleep.2005.12.014.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeApnea-hypopnea indexBody mass indexSleep apnea syndromeMale patientsApnea syndromeFemale patientsOnset latencyMean apnea-hypopnea indexSleep apnea hypopnea indexHigher apnea-hypopnea indexNon-rapid eye movement sleepSleep disorders centerREM onset latencyEye movement sleepAthens Medical SchoolPercent of menSleep efficiency indexTotal sleep timeGreek subjectsAspects of sleepSleep onset latencyNorth American clinicsEvangelismos HospitalNREM-AHI
2005
Auto-Titrating Continuous Positive Airway Pressure for Heart Failure Patients With Cheyne-Stokes Respiration and Central Sleep Apnea
Banno K, Okamura K, Kryger MH. Auto-Titrating Continuous Positive Airway Pressure for Heart Failure Patients With Cheyne-Stokes Respiration and Central Sleep Apnea. Circulation Journal 2005, 69: 1295. PMID: 16200689, DOI: 10.1253/circj.69.1295.Peer-Reviewed Original Research
2003
Oximeter Performance and Diagnostic Accuracy of Sleep Studies
Kryger M. Oximeter Performance and Diagnostic Accuracy of Sleep Studies. CHEST Journal 2003, 123: 2160. PMID: 12796211, DOI: 10.1378/chest.123.6.2160.Peer-Reviewed Original Research
1995
Nocturnal Oximetry: Is It a Screening Tool for Sleep Disorders?
Yamashiro Y, Kryger M. Nocturnal Oximetry: Is It a Screening Tool for Sleep Disorders? Sleep 1995, 18: 167-171. PMID: 7610312, DOI: 10.1093/sleep/18.3.167.Peer-Reviewed Original ResearchConceptsUpper airway resistance syndromeExcessive daytime sleepinessHome oximetrySleep disordersSevere OSA patientsTertiary referral hospitalPeriodic limb movementsSleep disorders centerNumber of desaturationsSleep-breathing disordersDisorders of sleepOxygen saturation dataMild OSAOSA patientsPolysomnographic diagnosisReferral hospitalSleep apneaResistance syndromeDaytime sleepinessDisorders CenterBlinded comparisonClinical diagnosisOximetryPolysomnographyPatients
1992
Polysomnography in Acutely III Intensive Care Unit Patients
Buckle P, Pouliot Z, Millar T, Kerr P, Kryger M. Polysomnography in Acutely III Intensive Care Unit Patients. CHEST Journal 1992, 102: 288-291. PMID: 1623769, DOI: 10.1378/chest.102.1.288.Peer-Reviewed Original ResearchConceptsCase reportDescriptive studyDouble-blind clinical trialIntensive care unit patientsStudy designCare unit patientsSeries of patientsCase report studySeries of casesUnit patientsCause of diseaseInvestigational protocolsClinical trialsClinical relevanceClinical researchReport studyChestGold standardPatientsReportPolysomnographyTherapyStudyThe importance of nasal resistance in obstructive sleep apnea syndrome.
Kerr P, Millar T, Buckle P, Kryger M. The importance of nasal resistance in obstructive sleep apnea syndrome. Journal Of Otolaryngology 1992, 21: 189-95. PMID: 1404570.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeUpper airway collapseSleep apnea syndromeNasal resistanceOSAS patientsApnea syndromeAirway collapseAmount of apneaArousals/hourChronic nasal obstructionNasal airflow resistanceBaseline data collectionNocturnal oxygenationOSAS populationTopical vasoconstrictorOSAS severityNasal obstructionClinical evidenceNocturnal polysomnographyPSG studiesSubjective improvementPosterior rhinomanometryElevated nasal resistanceConditions of baselineSleep architecture
1987
Dynamic in Vivo Response Characteristics of Three Oximeters: Hewlett-Packard 47201A, Biox III, and Nellcor N-100
West P, George C, Kryger M. Dynamic in Vivo Response Characteristics of Three Oximeters: Hewlett-Packard 47201A, Biox III, and Nellcor N-100. Sleep 1987, 10: 263-271. PMID: 3629089, DOI: 10.1093/sleep/10.3.263.Peer-Reviewed Original ResearchConceptsOxygen saturation measurementsHeart rateSaO2 measurementsOxygen saturationSleep apnea syndrome patientsArterial oxygen saturationPulse oximeterHewlett-Packard 47201ASyndrome patientsLinear regression analysisSaturation measurementsNellcor NOximeter sensorBiox IIIOximeterPatientsRegression analysisResponse relationshipSleepPulse oximeter sensorSaO2