2020
Co-activation of rhythms during alpha band oscillations as an interictal biomarker of exploding head syndrome
Sakellariou D, Nesbitt AD, Higgins S, Beniczky S, Rosenzweig J, Drakatos P, Gildeh N, Murphy PB, Kent B, Williams AJ, Kryger M, Goadsby PJ, Leschziner GD, Rosenzweig I. Co-activation of rhythms during alpha band oscillations as an interictal biomarker of exploding head syndrome. Cephalalgia 2020, 40: 949-958. PMID: 32276548, PMCID: PMC7412948, DOI: 10.1177/0333102420902705.Peer-Reviewed Original ResearchMeSH KeywordsAgedBrainCase-Control StudiesElectroencephalographyFemaleHumansMaleMiddle AgedParasomniasRetrospective StudiesConceptsHead syndromeRetrospective case-control studyPotential underlying pathophysiologyWhole-night EEGsSleep/wake periodsSleep disorders clinicCase-control studyWake-sleep statesExternal sensory stimuliElectroencephalographic biomarkerPatients' qualityUnderlying pathophysiologyDisorders ClinicSleep-wake transitionsPolysomnographic recordingsSyndromeAlpha-band oscillationsPatientsOscillatory activityWake periodAlpha rhythmSensory stimuliBand oscillationsLoud noisePreliminary findings
2007
Effect of Ramelteon, a selective MT1/MT2-receptor agonist, on respiration during sleep in mild to moderate COPD
Kryger M, Wang-Weigand S, Zhang J, Roth T. Effect of Ramelteon, a selective MT1/MT2-receptor agonist, on respiration during sleep in mild to moderate COPD. Sleep And Breathing 2007, 12: 243-250. PMID: 18060441, DOI: 10.1007/s11325-007-0156-4.Peer-Reviewed Original ResearchConceptsModerate chronic obstructive pulmonary diseaseChronic obstructive pulmonary diseaseAbnormal breathing eventsSelective MT1/MT2 receptor agonistMT1/MT2 receptor agonistMean apnea-hypopnea indexBreathing eventsEffects of ramelteonMT2 receptor agonistSingle bedtime doseApnea-hypopnea indexObstructive pulmonary diseaseNumber of awakeningsTotal sleep timeMelatonin receptor agonistBedtime dosePlacebo groupAdverse eventsPulmonary diseaseCrossover studyPhysical examinationReceptor agonistSleep efficiencySleep durationSleep timeThe visual scoring of sleep in adults.
Silber MH, Ancoli-Israel S, Bonnet MH, Chokroverty S, Grigg-Damberger MM, Hirshkowitz M, Kapen S, Keenan SA, Kryger MH, Penzel T, Pressman MR, Iber C. The visual scoring of sleep in adults. Journal Of Clinical Sleep Medicine 2007, 3: 121-31. PMID: 17557422, DOI: 10.5664/jcsm.26814.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdultElectroencephalographyElectrooculographyHumansPolysomnographyResearchResearch DesignSleepSleep StagesSleep Wake DisordersSleep, REM
2006
Hyperthyroidism in a patient referred for an assessment of obstructive sleep apnea syndrome
Banno K, Okamura K, Kryger MH. Hyperthyroidism in a patient referred for an assessment of obstructive sleep apnea syndrome. Sleep Medicine 2006, 7: 195-196. PMID: 16458602, DOI: 10.1016/j.sleep.2005.09.001.Peer-Reviewed Original Research
2005
Utilization of Healthcare Resources in Obstructive Sleep Apnea Syndrome: a 5Year Follow-Up Study in Men Using CPAP
Albarrak M, Banno K, Sabbagh AA, Delaive K, Walld R, Manfreda J, Kryger MH. Utilization of Healthcare Resources in Obstructive Sleep Apnea Syndrome: a 5Year Follow-Up Study in Men Using CPAP. Sleep 2005, 28: 1306-1311. PMID: 16295216, DOI: 10.1093/sleep/28.10.1306.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea syndromeIschemic heart diseaseHealthcare utilizationApnea syndromeHeart diseaseTreatment of OSASContinuous positive airway pressure useUntreated obstructive sleep apnea syndromeRetrospective observational cohort studyPositive airway pressure useEpworth Sleepiness Scale scoreLong-term health benefitsHigher healthcare utilizationObservational cohort studyApnea-hypopnea indexBody mass indexCPAP treatmentCohort studyPhysician visitsMass indexEligible menOSAS diagnosisFifth yearOSA diagnosis
1993
Benzodiazepines in Congestive Heart Failure: Effects of Temazepam on Arousability and Cheyne-Stokes Respiration
Biberdorf D, Steens R, Millar T, Kryger M. Benzodiazepines in Congestive Heart Failure: Effects of Temazepam on Arousability and Cheyne-Stokes Respiration. Sleep 1993, 16: 529-538. PMID: 8235237, DOI: 10.1093/sleep/16.6.529.Peer-Reviewed Original ResearchConceptsCheyne-Stokes respirationCongestive heart failureTotal sleep timePercentage of TSTApnea/hypopnea indexOxygen saturationTotal wake timeEffects of temazepamHeart failureSleep architectureDouble-blind crossover trialSevere congestive heart failureOvernight oxygen saturationStage 1 sleepHours of sleepSleep stage proportionsCHF patientsHypopnea indexMale patientsDaytime somnolenceCrossover trialSignificant changesFrequent arousalsDaytime alertnessSleep timeReview: Sleep in Heart Failure
Yamashiro Y, Kryger M. Review: Sleep in Heart Failure. Sleep 1993, 16: 513-523. PMID: 8235235, DOI: 10.1093/sleep/16.6.513.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1992
Polysomnography in Acutely III Intensive Care Unit Patients
Buckle P, Pouliot Z, Millar T, Kerr P, Kryger M. Polysomnography in Acutely III Intensive Care Unit Patients. CHEST Journal 1992, 102: 288-291. PMID: 1623769, DOI: 10.1378/chest.102.1.288.Peer-Reviewed Original ResearchConceptsCase reportDescriptive studyDouble-blind clinical trialIntensive care unit patientsStudy designCare unit patientsSeries of patientsCase report studySeries of casesUnit patientsCause of diseaseInvestigational protocolsClinical trialsClinical relevanceClinical researchReport studyChestGold standardPatientsReportPolysomnographyTherapyStudyThe importance of nasal resistance in obstructive sleep apnea syndrome.
Kerr P, Millar T, Buckle P, Kryger M. The importance of nasal resistance in obstructive sleep apnea syndrome. Journal Of Otolaryngology 1992, 21: 189-95. PMID: 1404570.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeUpper airway collapseSleep apnea syndromeNasal resistanceOSAS patientsApnea syndromeAirway collapseAmount of apneaArousals/hourChronic nasal obstructionNasal airflow resistanceBaseline data collectionNocturnal oxygenationOSAS populationTopical vasoconstrictorOSAS severityNasal obstructionClinical evidenceNocturnal polysomnographyPSG studiesSubjective improvementPosterior rhinomanometryElevated nasal resistanceConditions of baselineSleep architecture
1991
Subjective Versus Objective Evaluation of Hypnotic Efficacy: Experience with Zolpidem
Kryger M, Steljes D, Pouliot Z, Neufeld H, Odynski T. Subjective Versus Objective Evaluation of Hypnotic Efficacy: Experience with Zolpidem. Sleep 1991, 14: 399-407. PMID: 1759092, DOI: 10.1093/sleep/14.5.399.Peer-Reviewed Original ResearchConceptsTotal sleep timeSleep latencyNumber of awakeningsSleep timePSG findingsPersistent sleepHypnotic efficacySleep qualityPatients' subjective evaluationSubjective sleep qualityDecreased sleep latencyQuality of sleepShortened sleep latencyTotal wake timeObjective measuresPolysomnographic findingsSleepy patientsChronic insomniaWeeks' useIndividual patientsSleep efficiencySubjective reductionSubjective increaseObjective efficacyPatientsCentral sleep apnoea in congenital muscular dystrophy.
Kryger M, Steljes D, Yee W, Mate E, Smith S, Mahowald M. Central sleep apnoea in congenital muscular dystrophy. Journal Of Neurology Neurosurgery & Psychiatry 1991, 54: 710. PMID: 1940943, PMCID: PMC1014476, DOI: 10.1136/jnnp.54.8.710.Peer-Reviewed Original ResearchConceptsCentral sleep apnoeaSleep-disordered breathingCongenital muscular dystrophyMorning headachesSleep apnoeaNocturnal seizuresCongestive heart failureMuscular dystrophyPulmonary hypertensionClinical weaknessHeart failureExcessive daytimeNeuromuscular syndromeRespiratory dysfunctionNeuromuscular disordersApnoeaHeadacheSeizuresSymptomsBreathingDystrophyHypertensionDysfunctionSyndrome
1989
Respiration and Abnormal Sleep in Patients with Congestive Heart Failure
Hanly B, Millar T, Steljes D, Boert R, Frais M, Kryger M. Respiration and Abnormal Sleep in Patients with Congestive Heart Failure. CHEST Journal 1989, 96: 480-488. PMID: 2766808, DOI: 10.1378/chest.96.3.480.Peer-Reviewed Original ResearchConceptsCheyne-Stokes respirationCongestive heart failureStage 2 NREM sleepSlow-wave sleepSleep stage changesNREM sleepHyperpneic phaseHeart failureREM sleepAwake arterial oxygen saturationStable congestive heart failureSevere congestive heart failureStage 1Mean minimum SaO2Outcomes of patientsNumber of arousalsArterial oxygen saturationStage 1 sleepMinimum SaO2Severe hypoxemiaArterial oxygenationSignificant hypoxemiaClinical statusMean durationAbnormal sleepThe Effect of L-Tryptophan on Daytime Sleep Latency in Normals: Correlation with Blood Levels
George C, Millar T, Hanly P, Kryger M. The Effect of L-Tryptophan on Daytime Sleep Latency in Normals: Correlation with Blood Levels. Sleep 1989, 12: 345-353. PMID: 2669092, DOI: 10.1093/sleep/12.4.345.Peer-Reviewed Original ResearchConceptsSleep latencyBlood levelsRandom double-blind fashionRapid eye movement (REM) sleepDaytime sleep latencyL-tryptophan's effectsDouble-blind fashionEye movement sleepL-tryptophanSlow-wave sleepL-tryptophan levelsObjective sleepiness measuresKynurenic acidMovement sleepHealthy volunteersWave sleepDrug conditionsSeparate daysSleepSleepiness measuresPlaceboSignificant correlationEssential amino acidsDoseUrine
1987
Snoring in Normal Young Adults: Prevalence in Sleep Stages and Associated Changes in Oxygen Saturation, Heart Rate, and Breathing Pattern
Perez-Padilla J, West P, Kryger M. Snoring in Normal Young Adults: Prevalence in Sleep Stages and Associated Changes in Oxygen Saturation, Heart Rate, and Breathing Pattern. Sleep 1987, 10: 249-253. PMID: 3629087, DOI: 10.1093/sleep/10.3.249.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsElectroencephalographyFemaleHeart RateHumansMaleOxygenRespirationSleep Apnea SyndromesSleep StagesSnoringConceptsHeart rateContinuous snoringSleep stagesOxygen saturationPrevalence of snoringSignificant O2 desaturationMean heart rateNormal young adultsMean SaO2O2 desaturationDifferent pathogenesisDifferent sleep stagesNormal subjectsBreathing patternLight snorersBreathing frequencySnoringArrhythmiasYoung adultsPrevalenceStage 3Same sleep stageStage 2Associated ChangesSubjectsOxygenation and Breathing Pattern During Phasic and Tonic REM in Patients with Chronic Obstructive Pulmonary Disease
George C, West P, Kryger M. Oxygenation and Breathing Pattern During Phasic and Tonic REM in Patients with Chronic Obstructive Pulmonary Disease. Sleep 1987, 10: 234-243. PMID: 3629085, DOI: 10.1093/sleep/10.3.234.Peer-Reviewed Original ResearchMeSH KeywordsAgedElectroencephalographyFemaleHumansLung Diseases, ObstructiveMaleOxygenRespirationSleep StagesSleep, REMConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseTonic REMPhasic REMBreathing patternOxygen desaturationPulmonary diseaseSevere chronic obstructive pulmonary diseaseBreathing pattern changesAwake SaO2Nadir SaO2Total REMRespiratory neuronsMore desaturationMotor neuronsOxygen saturationREM sleepSaO2SaO2 differenceTransient decreaseRespiratory amplitudeNight studiesSleepDesaturationPatients
1985
Sleep and Respiration: Terminology and Methodology
West P, Kryger M. Sleep and Respiration: Terminology and Methodology. Clinics In Chest Medicine 1985, 6: 691-712. PMID: 3936667, DOI: 10.1016/s0272-5231(21)00406-8.Chapters
1983
Sighs During Sleep in Adult Humans
Perez-Padilla R, West P, Kryger M. Sighs During Sleep in Adult Humans. Sleep 1983, 6: 234-243. PMID: 6622880, DOI: 10.1093/sleep/6.3.234.Peer-Reviewed Original ResearchMeSH KeywordsAdultElectroencephalographyElectromyographyFemaleHeart RateHumansMaleRespirationRespiratory SoundsSleepSleep Apnea SyndromesSleep StagesTidal VolumeConceptsSleep stage changesCentral apneaGreat intersubject variationExpiratory flowRespiratory centerInspiratory flowEMG activityHeart rateRespiratory rateNormal adultsRespiratory cycleSleepIntersubject variationAdult humansRespiratory controlSleep stagesEEG frequenciesStage 1Normal variabilityPrevious breathStage changesSighsArousalHypoventilationApnea