2020
Sleep in the Aging Population
Miner B, Kryger MH. Sleep in the Aging Population. Sleep Medicine Clinics 2020, 15: 311-318. PMID: 32386704, DOI: 10.1016/j.jsmc.2020.02.016.ChaptersCo-activation of rhythms during alpha band oscillations as an interictal biomarker of exploding head syndrome
Sakellariou D, Nesbitt AD, Higgins S, Beniczky S, Rosenzweig J, Drakatos P, Gildeh N, Murphy PB, Kent B, Williams AJ, Kryger M, Goadsby PJ, Leschziner GD, Rosenzweig I. Co-activation of rhythms during alpha band oscillations as an interictal biomarker of exploding head syndrome. Cephalalgia 2020, 40: 949-958. PMID: 32276548, PMCID: PMC7412948, DOI: 10.1177/0333102420902705.Peer-Reviewed Original ResearchConceptsHead syndromeRetrospective case-control studyPotential underlying pathophysiologyWhole-night EEGsSleep/wake periodsSleep disorders clinicCase-control studyWake-sleep statesExternal sensory stimuliElectroencephalographic biomarkerPatients' qualityUnderlying pathophysiologyDisorders ClinicSleep-wake transitionsPolysomnographic recordingsSyndromeAlpha-band oscillationsPatientsOscillatory activityWake periodAlpha rhythmSensory stimuliBand oscillationsLoud noisePreliminary findings
2019
Greater health care utilization and cost associated with untreated sleep apnea.
Ding Q, Kryger M. Greater health care utilization and cost associated with untreated sleep apnea. Journal Of Clinical Sleep Medicine 2019, 16: 5-6. PMID: 31957652, PMCID: PMC7053011, DOI: 10.5664/jcsm.8152.Commentaries, Editorials and LettersCenters for Medicare and Medicaid Services Positive Airway Pressure Adherence Criteria May Limit Treatment to Many Medicare Beneficiaries.
Naik S, Al-Halawani M, Kreinin I, Kryger M. Centers for Medicare and Medicaid Services Positive Airway Pressure Adherence Criteria May Limit Treatment to Many Medicare Beneficiaries. Journal Of Clinical Sleep Medicine 2019, 15: 245-251. PMID: 30736874, PMCID: PMC6374085, DOI: 10.5664/jcsm.7626.Peer-Reviewed Original ResearchConceptsEvents/hAdherence criteriaPAP treatmentObstructive sleep apnea treatmentPositive airway pressure devicesWithholding of therapyApnea-hypopnea indexObstructive sleep apneaSleep apnea treatmentMedicaid Services reimbursementAdherence reportsBaseline characteristicsPAP devicesPAP adherenceAdherent participantsApnea treatmentSleep apneaNonadherent participantsAdherence dataMedicare beneficiariesAdherence patternsCMS criteriaAdherence expectationsPatientsMonths
2016
Effects of Suvorexant, an Orexin Receptor Antagonist, on Respiration during Sleep In Patients with Obstructive Sleep Apnea.
Sun H, Palcza J, Card D, Gipson A, Rosenberg R, Kryger M, Lines C, Wagner JA, Troyer MD. Effects of Suvorexant, an Orexin Receptor Antagonist, on Respiration during Sleep In Patients with Obstructive Sleep Apnea. Journal Of Clinical Sleep Medicine 2016, 12: 9-17. PMID: 26194728, PMCID: PMC4702197, DOI: 10.5664/jcsm.5382.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaOrexin receptor antagonistMean AHIRespiratory effectsSleep apneaMultiple dosesReceptor antagonistIntra-individual variabilityModerate obstructive sleep apneaEffects of suvorexantLowest effective doseSleep laboratory studiesTotal sleep timeMean SpO2Single doseRespiratory functionOxygen saturationPulse oximetryPlaceboPatientsSleep timeAHIDay 4Mean increaseSuvorexant
2015
The Use of a Fully Automated Automatic Adaptive Servoventilation Algorithm in the Acute and Long-term Treatment of Central Sleep Apnea
Javaheri S, Winslow D, McCullough P, Wylie P, Kryger MH. The Use of a Fully Automated Automatic Adaptive Servoventilation Algorithm in the Acute and Long-term Treatment of Central Sleep Apnea. CHEST Journal 2015, 148: 1454-1461. PMID: 25950507, DOI: 10.1378/chest.14-2966.Peer-Reviewed Original ResearchConceptsCentral apnea indexApnea-hypopnea indexCentral sleep apneaSleep apneaSleep qualityComplex sleep-disordered breathingASV deviceASV titrationAdaptive servoventilation devicesCongestive heart failureMonths of treatmentSleep-disordered breathingEpworth Sleepiness ScaleLong-term treatmentImproved sleep qualityMixed sleep apneaBetter sleep qualityApnea indexHeart failureObservational trialObstructive apneaBreathing disordersInspiratory pressureArousal indexDaytime sleepinessEffects of suvorexant, an orexin receptor antagonist, on breathing during sleep in patients with chronic obstructive pulmonary disease
Sun H, Palcza J, Rosenberg R, Kryger M, Siringhaus T, Rowe J, Lines C, Wagner JA, Troyer MD. Effects of suvorexant, an orexin receptor antagonist, on breathing during sleep in patients with chronic obstructive pulmonary disease. Respiratory Medicine 2015, 109: 416-426. PMID: 25661282, DOI: 10.1016/j.rmed.2014.12.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAzepinesCross-Over StudiesDouble-Blind MethodFemaleHumansMaleMiddle AgedOrexin Receptor AntagonistsPulmonary Disease, Chronic ObstructiveRespirationSeverity of Illness IndexSleepSleep Aids, PharmaceuticalSpirometryTreatment OutcomeTriazolesUnited StatesConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseSleep breathing disordersOrexin receptor antagonistPulmonary diseaseBreathing disordersReceptor antagonistModerate chronic obstructive pulmonary diseaseDay 4Effects of suvorexantModerate airflow limitationRespiratory depressant effectsApnea-hypopnea indexMaximum daily doseClinical research unitTotal sleep timeTreatment of insomniaMean AHICOPD patientsAirflow limitationHypopnea indexDaily doseMean SpO2Spirometry criteriaHypnotic medications
2014
A Matched Cohort Study of Postoperative Outcomes in Obstructive Sleep Apnea
Mutter TC, Chateau D, Moffatt M, Ramsey C, Roos LL, Kryger M. A Matched Cohort Study of Postoperative Outcomes in Obstructive Sleep Apnea. Anesthesiology 2014, 121: 707-718. PMID: 25247853, DOI: 10.1097/aln.0000000000000407.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressure therapyPositive airway pressure therapyObstructive sleep apneaAirway pressure therapySleep apneaPressure therapyOSA patientsCardiovascular complicationsPostoperative outcomesDiagnosis of OSAUndiagnosed obstructive sleep apneaAdult OSA patientsImportant risk modifiersPostoperative cardiovascular complicationsMatched Cohort StudyHealth administrative dataType of surgeryLarger efficacy trialPostoperative complicationsRespiratory complicationsCohort studyOSA severityPostoperative dayPreoperative diagnosisCardiac arrest
2013
The use of combined thermal/pressure polyvinylidene fluoride film airflow sensor in polysomnography
Kryger M, Eiken T, Qin L. The use of combined thermal/pressure polyvinylidene fluoride film airflow sensor in polysomnography. Sleep And Breathing 2013, 17: 1267-1273. PMID: 23716021, DOI: 10.1007/s11325-013-0832-5.Peer-Reviewed Original Research
2012
Respiratory Event Detection by a Positive Airway Pressure Device
Berry RB, Kushida CA, Kryger MH, Soto-Calderon H, Staley B, Kuna ST. Respiratory Event Detection by a Positive Airway Pressure Device. Sleep 2012, 35: 361-367. PMID: 22379242, PMCID: PMC3274337, DOI: 10.5665/sleep.1696.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaEvents/hrPositive airway pressure devicesApnea indexHypopnea indexPAP devicesRespiratory eventsSleep disorders centerPressure deviceBetter treatment efficacyRespiratory event detectionOxygen desaturationSleep apneaPAP treatmentBland-Altman analysisDisorders CenterPolysomnographyTreatment efficacyAHIInadequate treatmentManual scoringHypopnea detectionTrue negative eventsHrTreatment
2011
Positive Airway Pressure Initiation: A Randomized Controlled Trial to Assess the Impact of Therapy Mode and Titration Process on Efficacy, Adherence, and Outcomes
Kushida CA, Berry RB, Blau A, Crabtree T, Fietze I, Kryger MH, Kuna ST, Pegram GV, Penzel T. Positive Airway Pressure Initiation: A Randomized Controlled Trial to Assess the Impact of Therapy Mode and Titration Process on Efficacy, Adherence, and Outcomes. Sleep 2011, 34: 1083-1092. PMID: 21804670, PMCID: PMC3138163, DOI: 10.5665/sleep.1166.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureMinimum oxygen saturationAirway pressureFunctional outcomeOxygen saturationVeterans Affairs Medical CenterPositive pressure treatmentApnea-hypopnea indexObstructive sleep apneaSevere OSAMulticenter trialTreatment satisfactionControlled TrialsSleep apneaMajor efficacyStudy treatmentOutcome measuresMedical CenterSleep qualityTherapy modesMask comfortAdherenceEfficacyMonths
2009
Evidence‐Based Recommendations for the Assessment and Management of Sleep Disorders in Older Persons
Bloom HG, Ahmed I, Alessi CA, Ancoli‐Israel S, Buysse DJ, Kryger MH, Phillips BA, Thorpy MJ, Vitiello MV, Zee PC. Evidence‐Based Recommendations for the Assessment and Management of Sleep Disorders in Older Persons. Journal Of The American Geriatrics Society 2009, 57: 761-789. PMID: 19484833, PMCID: PMC2748127, DOI: 10.1111/j.1532-5415.2009.02220.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSpecific sleep disordersSleep disordersExpert-based recommendationsOlder personsRestless legs syndromeCircadian rhythm sleep disordersEvidence-based recommendationsSleep-related disordersPatient care practicesSerious medical problemTerm care settingsOlder adult populationMultiple medicationsPsychosocial comorbiditiesLegs syndromeSleep apneaCerebrovascular diseaseStrong bidirectional relationshipCardiovascular diseaseHigh prevalenceCare settingsSleep problemsHigh riskAmbulatory settingCare practices
2008
Association of Sleep Apnea Severity and Obesity with Insulin Resistance, C-Reactive Protein, and Leptin Levels in Male Patients with Obstructive Sleep Apnea
Kapsimalis F, Varouchakis G, Manousaki A, Daskas S, Nikita D, Kryger M, Gourgoulianis K. Association of Sleep Apnea Severity and Obesity with Insulin Resistance, C-Reactive Protein, and Leptin Levels in Male Patients with Obstructive Sleep Apnea. Lung 2008, 186: 209-217. PMID: 18365276, DOI: 10.1007/s00408-008-9082-x.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea severityObstructive sleep apneaNon-OSA groupBody mass indexModerate OSAS groupCRP levelsInsulin resistanceApnea severityOSAS groupMale patientsLeptin levelsSleep apneaSevere obstructive sleep apnea syndromeHomeostasis model assessment methodSevere sleep apneaSevere OSAS groupSleep apnea syndromeC-reactive proteinTotal sleep timeNocturnal hypoxemiaApnea syndromeModel assessment methodHip ratioMass index
2007
Effect of Ramelteon, a selective MT1/MT2-receptor agonist, on respiration during sleep in mild to moderate COPD
Kryger M, Wang-Weigand S, Zhang J, Roth T. Effect of Ramelteon, a selective MT1/MT2-receptor agonist, on respiration during sleep in mild to moderate COPD. Sleep And Breathing 2007, 12: 243-250. PMID: 18060441, DOI: 10.1007/s11325-007-0156-4.Peer-Reviewed Original ResearchConceptsModerate chronic obstructive pulmonary diseaseChronic obstructive pulmonary diseaseAbnormal breathing eventsSelective MT1/MT2 receptor agonistMT1/MT2 receptor agonistMean apnea-hypopnea indexBreathing eventsEffects of ramelteonMT2 receptor agonistSingle bedtime doseApnea-hypopnea indexObstructive pulmonary diseaseNumber of awakeningsTotal sleep timeMelatonin receptor agonistBedtime dosePlacebo groupAdverse eventsPulmonary diseaseCrossover studyPhysical examinationReceptor agonistSleep efficiencySleep durationSleep timeSleepy older drivers
Kryger M, George C. Sleepy older drivers. Canadian Medical Association Journal 2007, 177: 376-377. PMID: 17698831, PMCID: PMC1942097, DOI: 10.1503/cmaj.1070079.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2005
Symptoms of Obstructive Sleep Apnea in Patients with Nonalcoholic Fatty Liver Disease
Singh H, Pollock R, Uhanova J, Kryger M, Hawkins K, Minuk GY. Symptoms of Obstructive Sleep Apnea in Patients with Nonalcoholic Fatty Liver Disease. Digestive Diseases And Sciences 2005, 50: 2338-2343. PMID: 16416185, DOI: 10.1007/s10620-005-3058-y.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseSymptoms of OSANonalcoholic fatty liverObstructive sleep apneaFatty liver diseaseNAFLD patientsNASH patientsNonalcoholic steatohepatitisRisk factorsLiver diseaseSleep apneaInsulin resistancePrevalence of OSASleep apnea questionnaireIndependent risk factorPrevalence of diabetesBody mass indexPeripheral insulin resistanceLiver biopsyFatty liverMass indexTriglyceride levelsQuestionnaire criteriaPrevalence ratesPatients
2004
Sleep, health, and aging....
Kryger M. Sleep, health, and aging.... Geriatrics 2004, 59: 23. PMID: 14755864.Commentaries, Editorials and LettersSleep, health, and aging. Bridging the gap between science and clinical practice.
Kryger M, Monjan A, Bliwise D, Ancoli-Israel S. Sleep, health, and aging. Bridging the gap between science and clinical practice. Geriatrics 2004, 59: 24-6, 29-30. PMID: 14755865.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsExcessive daytime sleepinessPrevalence of insomniaProblems of sleepSlow-wave sleepQuality of lifeAdults age 65Age-related processesGeriatric populationDaytime sleepinessSleep disordersSleep efficiencyClinical practiceRestful sleepAge 65Depressed moodOlder populationSleepInsomniaLater lifeAdverse changesMemory problemsNight resultsComorbiditiesPopulationSleepiness
2002
What Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis?
Smith R, Ronald J, Delaive K, Walld R, Manfreda J, Kryger MH. What Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis? CHEST Journal 2002, 121: 164-172. PMID: 11796446, DOI: 10.1378/chest.121.1.164.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeBody mass indexChronic obstructive airways diseaseObstructive airways diseaseHealth care utilizationSleep apnea patientsControl subjectsApnea patientsAirway diseaseOSAS patientsCardiovascular diseaseObstructive sleep apnea patientsHealth care utilization measuresApnea-hypopnea indexCongestive heart failureEffect of obesityIschemic heart diseaseSleep apnea syndromeDegree of hypoxemiaSignificant independent predictorsLogistic regression analysisCertain cardiovascular disordersHealth care resourcesRegression analysisApnea syndrome
1998
Susceptibility of LDL to Oxidative Stress in Obstructive Sleep Apnea
Wali S, Bahammam A, Massaeli H, Pierce G, Iliskovic N, Singal P, Kryger M. Susceptibility of LDL to Oxidative Stress in Obstructive Sleep Apnea. Sleep 1998, 21: 290-296. PMID: 9595608, DOI: 10.1093/sleep/21.3.290.Peer-Reviewed Original ResearchConceptsLow-density lipoproteinObstructive sleep apneaOSA patientsNormal controlsOxidative stressSleep apneaPatient groupSevere hypoxiaSusceptibility of LDLFree radical challengeSame age groupCPAP therapySevere hypoxemiaRed blood cellsCardiovascular diseaseAntioxidant reserveGeneral populationPatientsIndividual low-density lipoproteinHours of exposureControl groupAge groupsGlutathione peroxidaseBlood cellsConjugated dienes