2022
Awakening
Kryger MH. Awakening. Sleep Health 2022, 8: 259-260. PMID: 35534389, DOI: 10.1016/j.sleh.2022.04.004.Commentaries, Editorials and Letters
2020
Home PAP devices in patients infected with COVID-19.
Kryger M, Thomas R. Home PAP devices in patients infected with COVID-19. Journal Of Clinical Sleep Medicine 2020, 16: 1217-1219. PMID: 32268933, PMCID: PMC7954070, DOI: 10.5664/jcsm.8490.Peer-Reviewed Original Research
2008
Influence of Sex on Sleep Regulatory Mechanisms
Paul KN, Turek FW, Kryger MH. Influence of Sex on Sleep Regulatory Mechanisms. Journal Of Women's Health 2008, 17: 1201-1208. PMID: 18710368, DOI: 10.1089/jwh.2008.0841.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCircadian RhythmFemaleGonadal HormonesHomeostasisHumansMaleSex FactorsSleepWakefulnessConceptsSleep regulatory mechanismsRodent studiesSleep-wake disordersReproductive hormonesExtended wakefulnessHomeostatic sleep regulatory mechanismsSleep consolidationSleep-wake amountsActivational influencesBiological sexRapid eye movement (REM) sleepSleep-wake architectureSleep amountSleep-wake cycleEffects of sexFemale reproductive hormonesSleepEye movement sleepSleep-wake statesInfluence of sexSleep disordersSleep statesPositive impactWakefulnessNeonatal exposure
2005
Cytokines and normal sleep
Kapsimalis F, Richardson G, Opp MR, Kryger M. Cytokines and normal sleep. Current Opinion In Pulmonary Medicine 2005, 11: 481-484. PMID: 16217172, DOI: 10.1097/01.mcp.0000183062.98665.6b.Peer-Reviewed Original ResearchConceptsNon-rapid eye movement sleepEye movement sleepNeurohormonal systemsMovement sleepSpontaneous non-rapid eye movement sleepMultiple biologic actionsHypothalamic preoptic areaReceptor-mediated effectsTumor necrosis factorNitric oxide synthesisEffects of cytokinesDirect receptor-mediated effectsImmune system responseMechanism of actionSleep-wake regulationSite of actionAdrenal axisBasal forebrainPreoptic areaNecrosis factorInterleukin-1Adrenal axesNormal sleepCytokinesOxide synthesis
2004
Review article: sleep and its relationship to gastro‐oesophageal reflux
Orr W, Heading R, Johnson L, Kryger M. Review article: sleep and its relationship to gastro‐oesophageal reflux. Alimentary Pharmacology & Therapeutics 2004, 20: 39-46. PMID: 15527463, DOI: 10.1111/j.1365-2036.2004.02239.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGastro-oesophageal reflux diseaseReflux eventsObstructive sleep apnea syndromeMost symptomatic patientsGastro-oesophageal refluxSleep apnea syndromeSlow gastric emptyingCommon gastrointestinal conditionsFrequency of swallowingReflux diseaseRespiratory complicationsSymptomatic patientsApnea syndromeGastric emptyingDecreased qualitySaliva productionPatientsSleepGastrointestinal conditionsPhysiological changesClearance behaviorConscious perceptionHeartburnComplicationsObesity
1997
Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy
Broughton R, Fleming J, George C, Hill J, Kryger M, Moldofsky H, Montplaisir J, Morehouse R, Moscovitch A, Murphy W. Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy. Neurology 1997, 49: 444-451. PMID: 9270575, DOI: 10.1212/wnl.49.2.444.Peer-Reviewed Original ResearchConceptsPlacebo-controlled crossover trialOnly significant adverse effectPlacebo-controlled trialExcessive daytime somnolenceMean sleep latencyPeriodic leg movementsEpworth Sleepiness ScaleDaytime sleep episodesInternational diagnostic criteriaSignificant adverse effectsHypertensive patientsMore nauseaBlood pressureDaily doseDaytime somnolenceExcessive daytimeSleep apneaCrossover trialSleep latencyModafinil 200Nocturnal sleepPatient's abilitySleepiness ScaleSleep initiationHeart rate
1989
The Effect of L-Tryptophan on Daytime Sleep Latency in Normals: Correlation with Blood Levels
George C, Millar T, Hanly P, Kryger M. The Effect of L-Tryptophan on Daytime Sleep Latency in Normals: Correlation with Blood Levels. Sleep 1989, 12: 345-353. PMID: 2669092, DOI: 10.1093/sleep/12.4.345.Peer-Reviewed Original ResearchConceptsSleep latencyBlood levelsRandom double-blind fashionRapid eye movement (REM) sleepDaytime sleep latencyL-tryptophan's effectsDouble-blind fashionEye movement sleepL-tryptophanSlow-wave sleepL-tryptophan levelsObjective sleepiness measuresKynurenic acidMovement sleepHealthy volunteersWave sleepDrug conditionsSeparate daysSleepSleepiness measuresPlaceboSignificant correlationEssential amino acidsDoseUrine