2016
Effects of Suvorexant, an Orexin Receptor Antagonist, on Respiration during Sleep In Patients with Obstructive Sleep Apnea.
Sun H, Palcza J, Card D, Gipson A, Rosenberg R, Kryger M, Lines C, Wagner JA, Troyer MD. Effects of Suvorexant, an Orexin Receptor Antagonist, on Respiration during Sleep In Patients with Obstructive Sleep Apnea. Journal Of Clinical Sleep Medicine 2016, 12: 9-17. PMID: 26194728, PMCID: PMC4702197, DOI: 10.5664/jcsm.5382.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaOrexin receptor antagonistMean AHIRespiratory effectsSleep apneaMultiple dosesReceptor antagonistIntra-individual variabilityModerate obstructive sleep apneaEffects of suvorexantLowest effective doseSleep laboratory studiesTotal sleep timeMean SpO2Single doseRespiratory functionOxygen saturationPulse oximetryPlaceboPatientsSleep timeAHIDay 4Mean increaseSuvorexant
2015
Effects of suvorexant, an orexin receptor antagonist, on breathing during sleep in patients with chronic obstructive pulmonary disease
Sun H, Palcza J, Rosenberg R, Kryger M, Siringhaus T, Rowe J, Lines C, Wagner JA, Troyer MD. Effects of suvorexant, an orexin receptor antagonist, on breathing during sleep in patients with chronic obstructive pulmonary disease. Respiratory Medicine 2015, 109: 416-426. PMID: 25661282, DOI: 10.1016/j.rmed.2014.12.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAzepinesCross-Over StudiesDouble-Blind MethodFemaleHumansMaleMiddle AgedOrexin Receptor AntagonistsPulmonary Disease, Chronic ObstructiveRespirationSeverity of Illness IndexSleepSleep Aids, PharmaceuticalSpirometryTreatment OutcomeTriazolesUnited StatesConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseSleep breathing disordersOrexin receptor antagonistPulmonary diseaseBreathing disordersReceptor antagonistModerate chronic obstructive pulmonary diseaseDay 4Effects of suvorexantModerate airflow limitationRespiratory depressant effectsApnea-hypopnea indexMaximum daily doseClinical research unitTotal sleep timeTreatment of insomniaMean AHICOPD patientsAirflow limitationHypopnea indexDaily doseMean SpO2Spirometry criteriaHypnotic medications
2008
The effects of ramelteon on respiration during sleep in subjects with moderate to severe chronic obstructive pulmonary disease
Kryger M, Roth T, Wang-Weigand S, Zhang J. The effects of ramelteon on respiration during sleep in subjects with moderate to severe chronic obstructive pulmonary disease. Sleep And Breathing 2008, 13: 79-84. PMID: 18584227, DOI: 10.1007/s11325-008-0196-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultComorbidityCross-Over StudiesDouble-Blind MethodFemaleHumansIndenesMaleOximetryPolysomnographyPulmonary Disease, Chronic ObstructiveReceptors, MelatoninSeverity of Illness IndexSleep Apnea SyndromesSleep Apnea, ObstructiveSleep Initiation and Maintenance DisordersSleep StagesYoung AdultConceptsSevere chronic obstructive pulmonary diseaseChronic obstructive pulmonary diseaseEffects of ramelteonObstructive pulmonary diseasePulmonary diseaseMean SaO2Respiratory depressant effectsApnea-hypopnea indexPoor sleep qualityTotal sleep timeMelatonin receptor agonistResultsNo significant differencesSignificant differencesAbnormal breathing eventsRamelteon 8Primary endpointAdverse eventsPersistent sleepCrossover studyDepressant effectPolysomnographic monitoringReceptor agonistRespiratory effortInsomnia treatmentSleep quality
2006
Gender differences on polysomnographic findings in Greek subjects with obstructive sleep apnea syndrome
Vagiakis E, Kapsimalis F, Lagogianni I, Perraki H, Minaritzoglou A, Alexandropoulou K, Roussos C, Kryger M. Gender differences on polysomnographic findings in Greek subjects with obstructive sleep apnea syndrome. Sleep Medicine 2006, 7: 424-430. PMID: 16740405, DOI: 10.1016/j.sleep.2005.12.014.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeApnea-hypopnea indexBody mass indexSleep apnea syndromeMale patientsApnea syndromeFemale patientsOnset latencyMean apnea-hypopnea indexSleep apnea hypopnea indexHigher apnea-hypopnea indexNon-rapid eye movement sleepSleep disorders centerREM onset latencyEye movement sleepAthens Medical SchoolPercent of menSleep efficiency indexTotal sleep timeGreek subjectsAspects of sleepSleep onset latencyNorth American clinicsEvangelismos HospitalNREM-AHI
2005
Use of polysomnography with synchronized digital video recording to diagnose pediatric sleep breathing disorders
Banno K, Kryger MH. Use of polysomnography with synchronized digital video recording to diagnose pediatric sleep breathing disorders. Canadian Medical Association Journal 2005, 173: 28-30. PMID: 15997038, PMCID: PMC1167805, DOI: 10.1503/cmaj.1041413.Peer-Reviewed Original Research
2002
Gender and Obstructive Sleep Apnea Syndrome, Part 1: Clinical Features
Kapsimalis F, Kryger MH. Gender and Obstructive Sleep Apnea Syndrome, Part 1: Clinical Features. Sleep 2002, 25: 409-416. PMID: 12071542, DOI: 10.1093/sleep/25.4.409.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObstructive sleep apnea syndromeSleep apnea syndromeApnea syndromeGeneral populationPrevalence of OSASOSAS casesPolysomnography findingsMale predominanceClinical featuresClinical presentationFemale patientsClinic populationEpidemiologic studiesPathophysiologic studiesSyndromeFemalesMalesPopulationLatest studiesPatientsPrevalenceDiseaseStudyOnly malesWomen
1993
Nasal Continuous Positive Airway Pressure
Kerr P, Shoenut J, Steens R, Millar T, Micflikier A, Kryger M. Nasal Continuous Positive Airway Pressure. Journal Of Clinical Gastroenterology 1993, 17: 276-280. PMID: 8308210, DOI: 10.1097/00004836-199312000-00002.Peer-Reviewed Original ResearchConceptsNasal continuous positive airway pressureContinuous positive airway pressureNocturnal gastroesophageal refluxLower esophageal pressurePositive airway pressureGastroesophageal refluxReflux patientsAirway pressureEsophageal pressureObstructive sleep apnea syndrome (OSAS) patientsSleep apnea syndrome patientsMean reflux durationNon-OSA patientsHealthy adult volunteersCPAP effectsNocturnal refluxEsophageal manometryMean durationIntraesophageal pressureLongest refluxSyndrome patientsHealthy volunteersReflux durationPatientsAdult volunteers
1991
Sleep quality in children with asthma treated with theophylline or cromolyn sodium
Avital A, Steljes D, Pasterkamp H, Kryger M, Sanchez I, Chernick V. Sleep quality in children with asthma treated with theophylline or cromolyn sodium. The Journal Of Pediatrics 1991, 119: 979-984. PMID: 1960623, DOI: 10.1016/s0022-3476(05)83062-8.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAsthmaChildCromolyn SodiumDouble-Blind MethodFemaleHumansMaleSleepTheophyllineConceptsCromolyn sodiumTheophylline periodPlacebo-controlled trialArterial oxygen desaturationTheophylline blood levelsArterial oxygen saturationTotal sleep timeYears of ageOxygen desaturationPulmonary functionTheophylline treatmentBlood levelsChild's asthmaCentral originSleep latencyProtective effectSleep qualityOxygen saturationSleep efficiencySleep timeAsthmaMicrograms/SleepMovement timeTreatment
1978
Flexible Fiberoptic Bronchoscopy in the Teaching Hospital Yield and Complications
Dreisin R, Albert R, Talley P, Kryger M, Scoggin C, Zwillich C. Flexible Fiberoptic Bronchoscopy in the Teaching Hospital Yield and Complications. CHEST Journal 1978, 74: 144-149. PMID: 679742, DOI: 10.1378/chest.74.2.144.Peer-Reviewed Original ResearchConceptsFiberoptic bronchoscopic proceduresBronchoscopic proceduresMalignant neoplasmsRate of complicationsFlexible fiberoptic bronchoscopyLobar atelectasisSevere bronchospasmAsthmatic patientsImmunosuppressed patientsTherapeutic subgroupsFiberoptic bronchoscopyTransbronchial biopsyPeripheral nodulesPulmonary disordersBronchoscopic lavageFiberoptic bronchoscopeInflammatory diseasesTeaching hospitalPatientsNormal hostsComplicationsOverall rateNeoplasmsPercentReliable toolFamilial aspects of decreased hypoxic drive in endurance athletes
Scoggin C, Doekel R, Kryger M, Zwillich C, Weil J. Familial aspects of decreased hypoxic drive in endurance athletes. Journal Of Applied Physiology 1978, 44: 464-468. PMID: 632187, DOI: 10.1152/jappl.1978.44.3.464.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCarbon DioxideFemaleGenesHumansHypercapniaHypoxiaMaleRespirationSports MedicineConceptsVentilatory responseEndurance athletesLong-distance runnersHypoxic ventilatory responseUnexplained respiratory failureFamilies of patientsHypercapnic responseRespiratory failureVentilatory responsivenessEndurance athleticsHealthy parentsShape parameter ANonathletic controlsHypoxic responseHypoxiaSimilar extentFamilial aspectsHypercapniaConsequence of conditioningAthletesRecent studiesFamilial influencesRunnersResponsePatients