2018
Hours of service regulations for professional drivers in continental Latin America
Simonelli G, Bellone G, Golombek D, Chada D, Glozier N, Capaldi VF, Vigo DE, Kryger MH. Hours of service regulations for professional drivers in continental Latin America. Sleep Health 2018, 4: 472-475. PMID: 30241663, DOI: 10.1016/j.sleh.2018.07.009.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2005
Experience in using split-day studies for suspected obstructive sleep apnea syndrome
Banno K, Al Sabbagh A, Delaive K, Higami S, Kryger MH. Experience in using split-day studies for suspected obstructive sleep apnea syndrome. Respiratory Medicine 2005, 99: 1334-1339. PMID: 16140233, DOI: 10.1016/j.rmed.2005.02.030.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea syndromeSleep breathing disordersApnea syndromeInconclusive studiesSevere obstructive sleep apnea syndromeSevere daytime sleepinessEligible casesBreathing disordersDefinitive diagnosisFinal diagnosisDaytime sleepinessMovement disordersSleep disordersSleep studiesPatientsSleep deprivationDiagnosisSubjective sleepinessAdditional assessmentDisordersInsufficient dataSyndromeSleepinessConclusive studies
1999
Health Care Utilization in the 10 Years Prior to Diagnosis in Obstructive Sleep Apnea Syndrome Patients
Ronald J, Delaive K, Roos L, Manfreda J, Bahammam A, Kryger M. Health Care Utilization in the 10 Years Prior to Diagnosis in Obstructive Sleep Apnea Syndrome Patients. Sleep 1999, 22: 225-229. PMID: 10201067, DOI: 10.1093/sleep/22.2.225.Peer-Reviewed Original ResearchMeSH KeywordsCanadaDatabases as TopicFemaleHealth ServicesHumansMaleMiddle AgedSleep Apnea SyndromesTime FactorsConceptsObstructive sleep apnea syndrome (OSAS) patientsSleep apnea syndrome patientsOSAS patientsSyndrome patientsHealth servicesHealth care utilizationHealth service utilizationInitial diagnostic evaluationHealth care resourcesHealth care servicesOvernight hospitalizationOSA patientsSuch patientsCare utilizationSleep apneaTime patientsRisk factorsService utilizationDiagnostic evaluationGeneral populationTobacco consumptionPatientsCare resourcesCare servicesAlcohol usage
1993
A Developmental Study of the Dose-Response Curve of the Respiratory Sensory Reflex
Alvaro R, De Almeida V, Kwiatkowski K, Cates D, Kryger M, Rigatto H. A Developmental Study of the Dose-Response Curve of the Respiratory Sensory Reflex. American Journal Of Respiratory And Critical Care Medicine 1993, 148: 1013-1017. PMID: 8214918, DOI: 10.1164/ajrccm/148.4_pt_1.1013.Peer-Reviewed Original Research
1992
Nasal CPAP Reduces Gastroesophageal Reflux in Obstructive Sleep Apnea Syndrome
Kerr P, Shoenut J, Millar T, Buckle P, Kryger M. Nasal CPAP Reduces Gastroesophageal Reflux in Obstructive Sleep Apnea Syndrome. CHEST Journal 1992, 101: 1539-1544. PMID: 1600771, DOI: 10.1378/chest.101.6.1539.Peer-Reviewed Original ResearchConceptsNocturnal gastroesophageal refluxGastroesophageal refluxNasal CPAPIntrathoracic pressureNasal continuous positive airway pressureObstructive sleep apnea syndrome (OSAS) patientsContinuous positive airway pressureSleep apnea syndrome patientsObstructive sleep apnea syndromePositive airway pressureSleep apnea syndromeEsophageal pressure recordingAntireflux therapyGER frequencyAirway pressureOSAS patientsApnea syndromeClinical impressionSyndrome patientsPressure recordingsCPAPPatientsConsecutive daysNight twoMean percentage
1990
The Entrainment of Low Frequency Breathing Periodicity
Millar T, Hardy P, Hunt B, Frais M, Kryger M. The Entrainment of Low Frequency Breathing Periodicity. CHEST Journal 1990, 98: 1143-1148. PMID: 2225959, DOI: 10.1378/chest.98.5.1143.Peer-Reviewed Original Research
1988
Mortality and Apnea Index in Obstructive Sleep Apnea Experience in 385 Male Patients
He J, Kryger M, Zorick F, Conway W, Roth T. Mortality and Apnea Index in Obstructive Sleep Apnea Experience in 385 Male Patients. CHEST Journal 1988, 94: 9-14. PMID: 3289839, DOI: 10.1378/chest.94.1.9.Peer-Reviewed Original ResearchConceptsApnea indexObstructive sleep apneaNasal CPAPOSA patientsCumulative survivalObstructive sleep apnea experienceEight-year survivalMale OSAS patientsUntreated OSA patientsGreater mortalityYears of ageUPPP patientsLatter patientsMale patientsSleep apneaPatientsSurvival curvesMortalityTracheostomyCPAPSurvivalIndexApneaUPPPTherapy
1986
Alteration in Breathing Pattern with Progression of Chronic Obstructive Pulmonary Disease1,2
Loveridge B, West P, Kryger M, Anthonisen N. Alteration in Breathing Pattern with Progression of Chronic Obstructive Pulmonary Disease1,2. American Journal Of Respiratory And Critical Care Medicine 1986, 134: 930-934. PMID: 3777689, DOI: 10.1164/arrd.1986.134.5.930.Peer-Reviewed Original ResearchMeSH KeywordsForced Expiratory VolumeHumansLung Diseases, ObstructiveRespirationSpirometryTidal VolumeTime FactorsConceptsChronic obstructive pulmonary diseaseRespiratory failureSevere groupBreathing patternRespiratory inductance plethysmographStable chronic obstructive pulmonary diseaseRespiratory failure groupChronic obstructive pulmonaryObstructive pulmonary diseaseSignificant decreaseVT/TISeverity of diseasePulmonary diseaseAcute reliefFailure groupSupplemental O2Minute ventilationVentilatory controlTidal volumeModerate groupMechanical abnormalitiesInductance plethysmographBreathing frequencySeated positionFEV1
1984
Breathing Patterns in Patients with Chronic Obstructive Pulmonary Disease1,2
Loveridge B, West P, Anthonisen N, Kryger M. Breathing Patterns in Patients with Chronic Obstructive Pulmonary Disease1,2. American Journal Of Respiratory And Critical Care Medicine 1984, 130: 730-3. PMID: 6497155, DOI: 10.1164/arrd.1984.130.5.730.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseCOPD groupRespiratory inductance plethysmographRib cageStable chronic obstructive pulmonary diseaseSex-matched control subjectsChronic obstructive pulmonaryObstructive pulmonary diseaseTi/TtotCOPD patientsMean PaO2Pulmonary diseaseControl subjectsMinute ventilationExpiratory timeInspiratory flowSitting positionTidal volumeNormal subjectsBreathing patternInductance plethysmographPatientsRespiratory cycleMean numberNeural control
1983
The role of protriptyline in obstructive sleep apnea.
Brownell L, Perez-Padilla R, West P, Kryger M. The role of protriptyline in obstructive sleep apnea. European Respiratory Journal 1983, 19: 621-4. PMID: 6360257.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTreatment of mildLong-term treatmentTricyclic agentsObese patientsObstructive apneaClinical statusCrossover trialImproved oxygenationInvasive treatmentTerm treatmentPatientsApneaArousal frequencySomnolenceProtriptylineTreatmentTrialsOxygenationREMTherapyMildMonths
1982
Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial
Brownell L, West P, Sweatman P, Acres J, Kryger M. Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial. New England Journal Of Medicine 1982, 307: 1037-1042. PMID: 6750396, DOI: 10.1056/nejm198210213071701.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTotal sleep timeApnea timeApnea durationBody weightSleep timeDouble-blind crossover studyDouble-blind trialMonths of treatmentWeeks of treatmentNocturnal oxygenationREM reductionDaytime somnolenceCrossover studyTricyclic antidepressantsApneaArousal frequencySimilar decreaseProtriptylineSimilar improvementsTreatmentOxygenationDurationSomnolence
1980
The Effect of Low Flow Oxygen Therapy on the Chemical Control of Ventilation in Patients with Hypoxemic COPD1–3
Fleetham J, Bradley C, Kryger M, Anthonisen N. The Effect of Low Flow Oxygen Therapy on the Chemical Control of Ventilation in Patients with Hypoxemic COPD1–3. American Journal Of Respiratory And Critical Care Medicine 1980, 122: 833-40. PMID: 6779682, DOI: 10.1164/arrd.1980.122.6.833.Peer-Reviewed Original ResearchMeSH KeywordsCarbon DioxideHumansHypoxiaLung Diseases, ObstructiveOxygen Inhalation TherapyRespirationTime FactorsConceptsChronic obstructive pulmonary diseaseHypoxemic chronic obstructive pulmonary diseaseOxygen therapyHypoxic responseLow-flow oxygen therapyCentral ventilatory driveFlow oxygen therapyNocturnal oxygen therapyObstructive pulmonary diseaseArterial O2 saturationNocturnal oxygenPulmonary diseaseSuch patientsVentilatory driveMinute ventilationInspiratory flowO2 saturationPatientsTherapyContinuous oxygenMonthsHypoxiaInitial responseHypoxemiaVentilation
1976
Clinical Semi-Starvation — Depression of Hypoxic Ventilatory Response
Doekel R, Zwillich C, Scoggin C, Kryger M, Weil J. Clinical Semi-Starvation — Depression of Hypoxic Ventilatory Response. New England Journal Of Medicine 1976, 295: 358-361. PMID: 819829, DOI: 10.1056/nejm197608122950703.Peer-Reviewed Original ResearchConceptsHypoxic ventilatory responseVentilatory responseHypercapnic ventilatory responseMetabolic rateRespiratory failureIntravenous fluidsDecreased metabolic rateCarbohydrate dietNormal subjectsCaloric restrictionDay 10HypercapniaSupplemental electrolytesResponse responseSubjectsResponseHypoxemiaDecreaseHypoxiaAlimentation