2007
The visual scoring of sleep in adults.
Silber MH, Ancoli-Israel S, Bonnet MH, Chokroverty S, Grigg-Damberger MM, Hirshkowitz M, Kapen S, Keenan SA, Kryger MH, Penzel T, Pressman MR, Iber C. The visual scoring of sleep in adults. Journal Of Clinical Sleep Medicine 2007, 3: 121-31. PMID: 17557422, DOI: 10.5664/jcsm.26814.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2005
Long-term treatment of sleep breathing disorder in a patient with Huntington's disease
Banno K, Hobson DE, Kryger MH. Long-term treatment of sleep breathing disorder in a patient with Huntington's disease. Parkinsonism & Related Disorders 2005, 11: 261-264. PMID: 15878590, DOI: 10.1016/j.parkreldis.2005.01.005.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureSleep breathing disordersApnea-hypopnea indexBreathing disordersHuntington's diseaseRapid eye movement (REM) sleepPositive airway pressureObstructive sleep apneaLong-term treatmentEye movement sleepQuality of lifeAutosomal dominant neurodegenerative disorderAirway pressureHD patientsSleep apneaRespiratory arousalsMovement sleepDominant neurodegenerative disorderDaytime alertnessSleep structureNeurodegenerative disordersDiseaseDisordersApneaPatients
1995
Irregular breathing during sleep in patients with panic disorder
Stein M, Millar T, Larsen D, Kryger M. Irregular breathing during sleep in patients with panic disorder. American Journal Of Psychiatry 1995, 152: 1168-1173. PMID: 7625465, DOI: 10.1176/ajp.152.8.1168.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsPanic disorderComparison subjectsIrregular breathingSleep panic attacksSubgroup of patientsMedication-free patientsNocturnal breathing patternsNocturnal breathingSleep breathingNight of sleepRespiratory irregularitiesTidal volumeVentilatory variabilityBreathing patternPatientsAwake statePanic attacksSubtle disordersBreathingDisordersSleepSleep samplesPossible relationshipSubjects
1993
Benzodiazepines in Congestive Heart Failure: Effects of Temazepam on Arousability and Cheyne-Stokes Respiration
Biberdorf D, Steens R, Millar T, Kryger M. Benzodiazepines in Congestive Heart Failure: Effects of Temazepam on Arousability and Cheyne-Stokes Respiration. Sleep 1993, 16: 529-538. PMID: 8235237, DOI: 10.1093/sleep/16.6.529.Peer-Reviewed Original ResearchConceptsCheyne-Stokes respirationCongestive heart failureTotal sleep timePercentage of TSTApnea/hypopnea indexOxygen saturationTotal wake timeEffects of temazepamHeart failureSleep architectureDouble-blind crossover trialSevere congestive heart failureOvernight oxygen saturationStage 1 sleepHours of sleepSleep stage proportionsCHF patientsHypopnea indexMale patientsDaytime somnolenceCrossover trialSignificant changesFrequent arousalsDaytime alertnessSleep timeNocturnal Cluster Headache Associated with Sleep Apnea. A Case Report
Buckle P, Kerr P, Kryger M. Nocturnal Cluster Headache Associated with Sleep Apnea. A Case Report. Sleep 1993, 16: 487-489. PMID: 8378690, DOI: 10.1093/sleep/16.5.487.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaCluster headacheRapid eye movement (REM) sleepChronic cluster headacheEye movement sleepNasal CPAPOxygen desaturationCase reportMovement sleepHeadache AssociatedBackup rateREM sleepTypical headacheHeadacheApneaSleep labFurther treatmentSleepDesaturationTreatmentBiPAPCPAPMedicationsEffects of Zolpidem and Triazolam on Sleep and Respiration in Mild to Moderate Chronic Obstructive Pulmonary Disease
Steens R, Pouliot Z, Millar T, Kryger M, George C. Effects of Zolpidem and Triazolam on Sleep and Respiration in Mild to Moderate Chronic Obstructive Pulmonary Disease. Sleep 1993, 16: 318-326. PMID: 8341892, DOI: 10.1093/sleep/16.4.318.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseModerate chronic obstructive pulmonary diseaseObstructive pulmonary diseaseEffects of zolpidemPulmonary diseaseDrug conditionsNocturnal arterial oxygen desaturationArterial oxygen desaturationApnea-hypopnea indexGroup of patientsArterial oxygen saturationNumber of awakeningsTotal sleep timeHours of sleepSignificant differencesSubjective sleep variablesNew hypnotic agentOxygen desaturationCrossover studyHypnotic agentsSleep problemsSleep qualityOxygen saturationSleep efficiencyActive drugSleep in nondepressed patients with panic disorder: II. Polysomnographic assessment of sleep architecture and sleep continuity
Stein M, Enns M, Kryger M. Sleep in nondepressed patients with panic disorder: II. Polysomnographic assessment of sleep architecture and sleep continuity. Journal Of Affective Disorders 1993, 28: 1-6. PMID: 8326076, DOI: 10.1016/0165-0327(93)90071-q.Peer-Reviewed Original ResearchConceptsPanic disorderAge-comparable healthy controlsNon-depressed patientsTotal sleep timeNondepressed patientsPolysomnographic assessmentDepressed patientsHealthy controlsMajor depressionSleep architectureSleep continuitySleep maintenanceDelta sleepEEG sleepPatientsNormal sleepSleep timeSleepDisordersModest reductionImpairment
1990
Sleep in Postpolio Syndrome
Steljes D, Kryger M, Kirk B, Millar T. Sleep in Postpolio Syndrome. CHEST Journal 1990, 98: 133-140. PMID: 2361379, DOI: 10.1378/chest.98.1.133.Peer-Reviewed Original ResearchConceptsNasal mask ventilationPost-polio patientsGroup 1 patientsNasal CPAPPoor sleep qualityMask ventilationMixed apneaSleep qualityHypoventilation syndromeRespiratory complaintsPercentage stage 1 sleepRapid eye movement (REM) sleepNasal mechanical ventilationNight-time polysomnographyPost-polio symptomsSignificant O2 desaturationGroup 2 patientsRespiratory muscle weaknessNumber of arousalsEye movement sleepImproved sleep qualityPost-polio syndromeStage 1 sleepTotal sleep timeSlow-wave sleepCheyne-Stokes respiration in cardiac failure.
Kryger M, Hanly P. Cheyne-Stokes respiration in cardiac failure. Progress In Clinical And Biological Research 1990, 345: 215-24; discussion 224-6. PMID: 2377634.Peer-Reviewed Original Research
1988
Sleep Apnea and Body Position during Sleep
George C, Millar T, Kryger M. Sleep Apnea and Body Position during Sleep. Sleep 1988, 11: 90-99. PMID: 3363274, DOI: 10.1093/sleep/11.1.90.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexRapid eye movementLateral decubitus positionApnea durationObese patientsSleep apneaDecubitus positionBody positionSleep stagesSevere sleep apneaObstructive sleep apneaNon-REM sleepMajor treatment interventionApnea frequencyOvernight studyPatientsTreatment interventionsApneaNREMEye movementsSleepPrevious studiesPolysomnogramSupinePosition changes
1987
Oxygenation and Breathing Pattern During Phasic and Tonic REM in Patients with Chronic Obstructive Pulmonary Disease
George C, West P, Kryger M. Oxygenation and Breathing Pattern During Phasic and Tonic REM in Patients with Chronic Obstructive Pulmonary Disease. Sleep 1987, 10: 234-243. PMID: 3629085, DOI: 10.1093/sleep/10.3.234.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseTonic REMPhasic REMBreathing patternOxygen desaturationPulmonary diseaseSevere chronic obstructive pulmonary diseaseBreathing pattern changesAwake SaO2Nadir SaO2Total REMRespiratory neuronsMore desaturationMotor neuronsOxygen saturationREM sleepSaO2SaO2 differenceTransient decreaseRespiratory amplitudeNight studiesSleepDesaturationPatients
1985
Sleep and Respiration: Terminology and Methodology
West P, Kryger M. Sleep and Respiration: Terminology and Methodology. Clinics In Chest Medicine 1985, 6: 691-712. PMID: 3936667, DOI: 10.1016/s0272-5231(21)00406-8.ChaptersSleep and Control of Heart Rate
George C, Kryger M. Sleep and Control of Heart Rate. Clinics In Chest Medicine 1985, 6: 595-601. PMID: 3853478, DOI: 10.1016/s0272-5231(21)00397-x.Peer-Reviewed Original ResearchConceptsHeart rateTotal peripheral vascular resistanceSinus arrhythmiaExaggerated sinus arrhythmiaAutonomic nervous system activityPeripheral vascular resistanceTransient AV blockNormal hemoglobin concentrationAutonomic nervous activityNervous system activityHeart rate responseStages of sleepVascular resistanceBlood pressureVentricular functionCardiac outputAV blockRhythm disturbancesCarotid bodyLung inflationNervous activityREM sleepRespiratory arrhythmiaHemoglobin concentrationRespiratory rateBreathing during Sleep in Patients with Interstitial Lung Disease1–3
Perez-Padilla R, West P, Lertzman M, Kryger M. Breathing during Sleep in Patients with Interstitial Lung Disease1–3. American Journal Of Respiratory And Critical Care Medicine 1985, 132: 224-9. PMID: 2411177, DOI: 10.1164/arrd.1985.132.2.224.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseTi/TtotControl subjectsSleep qualityREM sleepRapid shallow breathing patternSex-matched control subjectsIncidence of snoringShallow breathing patternIncidence of apneaPoor sleep qualityAwake SaO2Lung diseaseExpiratory timeInspiratory timeLung reflexesOxygen saturationGreater abnormalitiesNREM sleepSleep structureHypopnea periodsBreathing patternPatientsVolume indexSleep
1982
Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial
Brownell L, West P, Sweatman P, Acres J, Kryger M. Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial. New England Journal Of Medicine 1982, 307: 1037-1042. PMID: 6750396, DOI: 10.1056/nejm198210213071701.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTotal sleep timeApnea timeApnea durationBody weightSleep timeDouble-blind crossover studyDouble-blind trialMonths of treatmentWeeks of treatmentNocturnal oxygenationREM reductionDaytime somnolenceCrossover studyTricyclic antidepressantsApneaArousal frequencySimilar decreaseProtriptylineSimilar improvementsTreatmentOxygenationDurationSomnolence
1981
Sleep Disorders in Chronic Airflow Obstruction
Fleetham J, Kryger M. Sleep Disorders in Chronic Airflow Obstruction. Medical Clinics Of North America 1981, 65: 549-561. PMID: 7017303, DOI: 10.1016/s0025-7125(16)31513-9.Peer-Reviewed Original ResearchConceptsChronic airflow obstructionAirflow obstructionPulmonary hypertensionCardiac arrhythmiasLess rapid eye movement sleepRapid eye movement (REM) sleepSecondary pulmonary hypertensionNocturnal oxygen therapyGas exchange abnormalitiesSleep apnea syndromeEye movement sleepSleep stage changesApnea syndromeOxygen therapyPhysiologic disturbancesMovement sleepSleep disordersSleep profilesPatientsObstructionSleepHypertensionArrhythmiasStage changesSyndrome