2008
The effects of ramelteon on respiration during sleep in subjects with moderate to severe chronic obstructive pulmonary disease
Kryger M, Roth T, Wang-Weigand S, Zhang J. The effects of ramelteon on respiration during sleep in subjects with moderate to severe chronic obstructive pulmonary disease. Sleep And Breathing 2008, 13: 79-84. PMID: 18584227, DOI: 10.1007/s11325-008-0196-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultComorbidityCross-Over StudiesDouble-Blind MethodFemaleHumansIndenesMaleOximetryPolysomnographyPulmonary Disease, Chronic ObstructiveReceptors, MelatoninSeverity of Illness IndexSleep Apnea SyndromesSleep Apnea, ObstructiveSleep Initiation and Maintenance DisordersSleep StagesYoung AdultConceptsSevere chronic obstructive pulmonary diseaseChronic obstructive pulmonary diseaseEffects of ramelteonObstructive pulmonary diseasePulmonary diseaseMean SaO2Respiratory depressant effectsApnea-hypopnea indexPoor sleep qualityTotal sleep timeMelatonin receptor agonistResultsNo significant differencesSignificant differencesAbnormal breathing eventsRamelteon 8Primary endpointAdverse eventsPersistent sleepCrossover studyDepressant effectPolysomnographic monitoringReceptor agonistRespiratory effortInsomnia treatmentSleep quality
2007
The visual scoring of sleep in adults.
Silber MH, Ancoli-Israel S, Bonnet MH, Chokroverty S, Grigg-Damberger MM, Hirshkowitz M, Kapen S, Keenan SA, Kryger MH, Penzel T, Pressman MR, Iber C. The visual scoring of sleep in adults. Journal Of Clinical Sleep Medicine 2007, 3: 121-31. PMID: 17557422, DOI: 10.5664/jcsm.26814.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSafety of ramelteon in individuals with mild to moderate obstructive sleep apnea
Kryger M, Wang-Weigand S, Roth T. Safety of ramelteon in individuals with mild to moderate obstructive sleep apnea. Sleep And Breathing 2007, 11: 159-164. PMID: 17294232, DOI: 10.1007/s11325-006-0096-4.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaNext-day residual effectsApnea-hypopnea indexSleep apneaPost-sleep questionnaireAdverse eventsSelective MT1/MT2 receptor agonistMT1/MT2 receptor agonistMT2 receptor agonistSafety of ramelteonUrinary tract infectionArterial oxygen saturationControl of breathingRespiratory inductance plethysmographyRamelteon groupPlacebo groupTract infectionsCrossover studyWashout periodDepressant effectSleep QuestionnaireHypopneic eventsRespiratory effortInsomnia treatmentOxygen saturation
2005
Differences between Men and Women in the Clinical Presentation of Patients Diagnosed with Obstructive Sleep Apnea Syndrome
Shepertycky M, Banno K, Kryger MH. Differences between Men and Women in the Clinical Presentation of Patients Diagnosed with Obstructive Sleep Apnea Syndrome. Sleep 2005, 28: 309-314. PMID: 16173651, DOI: 10.1093/sleep/28.3.309.Peer-Reviewed Original ResearchConceptsEpworth Sleepiness Scale scoreApnea-hypopnea indexBody mass indexClinical presentationMass indexObstructive sleep apnea syndrome (OSA) resultsTertiary university-based medical centerScale scoreRetrospective chart review analysisObstructive sleep apnea syndromeUniversity-based medical centerLaboratory polysomnographic studiesMain presenting symptomChart review analysisUpper airway anatomySleep apnea syndromeHistory of depressionGender-related differencesLess alcohol consumptionPolysomnographic findingsPresenting symptomApnea syndromeHypothyroid diseasePolysomnographic studyPrimary complaint
1999
Upper Airway Resistance Syndrome: Effect of Nasal Dilation, Sleep Stage, and Sleep Position
Bahammam A, Tate R, Manfreda J, Kryger M. Upper Airway Resistance Syndrome: Effect of Nasal Dilation, Sleep Stage, and Sleep Position. Sleep 1999, 22: 592-598. PMID: 10450594, DOI: 10.1093/sleep/22.5.592.Peer-Reviewed Original ResearchConceptsUpper airway resistance syndromeStage 1 sleepSleep positionNasal dilationDesaturation timeSleep architectureExternal nasal dilationArousal indexCardiorespiratory parametersSleep stagesNREM sleepNasal cross-sectional areaExternal nasal dilatorSlow-wave sleepObstructive sleepAirway collapsibilityConsecutive patientsNasal dilatorNasal obstructionResistance syndromeSupine positionIntrapharyngeal pressureIndirect markerWave sleepCrossover designClinical presentations of obstructive sleep apnea syndrome
Skomro R, Kryger M. Clinical presentations of obstructive sleep apnea syndrome. Progress In Cardiovascular Diseases 1999, 41: 331-340. PMID: 10406327, DOI: 10.1053/pcad.1999.0410331.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea syndromeQuality of lifeApnea syndromeClinical presentationTreatment of OSASClinical practiceBlood pressure controlIschemic heart diseaseHealth care professionalsMiddle-aged adultsCardiovascular morbidityPulmonary hypertensionMajor sequelaeUnderrecognized disorderCardiorespiratory failureDaytime somnolenceUpper airwayPrompt evaluationHeart diseaseRisk factorsClinical impressionNeurocognitive complaintsCare professionalsPressure control
1998
Susceptibility of LDL to Oxidative Stress in Obstructive Sleep Apnea
Wali S, Bahammam A, Massaeli H, Pierce G, Iliskovic N, Singal P, Kryger M. Susceptibility of LDL to Oxidative Stress in Obstructive Sleep Apnea. Sleep 1998, 21: 290-296. PMID: 9595608, DOI: 10.1093/sleep/21.3.290.Peer-Reviewed Original ResearchConceptsLow-density lipoproteinObstructive sleep apneaOSA patientsNormal controlsOxidative stressSleep apneaPatient groupSevere hypoxiaSusceptibility of LDLFree radical challengeSame age groupCPAP therapySevere hypoxemiaRed blood cellsCardiovascular diseaseAntioxidant reserveGeneral populationPatientsIndividual low-density lipoproteinHours of exposureControl groupAge groupsGlutathione peroxidaseBlood cellsConjugated dienes
1997
Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy
Broughton R, Fleming J, George C, Hill J, Kryger M, Moldofsky H, Montplaisir J, Morehouse R, Moscovitch A, Murphy W. Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy. Neurology 1997, 49: 444-451. PMID: 9270575, DOI: 10.1212/wnl.49.2.444.Peer-Reviewed Original ResearchConceptsPlacebo-controlled crossover trialOnly significant adverse effectPlacebo-controlled trialExcessive daytime somnolenceMean sleep latencyPeriodic leg movementsEpworth Sleepiness ScaleDaytime sleep episodesInternational diagnostic criteriaSignificant adverse effectsHypertensive patientsMore nauseaBlood pressureDaily doseDaytime somnolenceExcessive daytimeSleep apneaCrossover trialSleep latencyModafinil 200Nocturnal sleepPatient's abilitySleepiness ScaleSleep initiationHeart rate
1996
L-DOPA/Carbidopa for Nocturnal Movement Disorders in Uremia
Walker S, Fine A, Kryger M. L-DOPA/Carbidopa for Nocturnal Movement Disorders in Uremia. Sleep 1996, 19: 214-218. PMID: 8723378, DOI: 10.1093/sleep/19.3.214.Peer-Reviewed Original ResearchConceptsL-dopa/carbidopaRestless legs syndromeSlow-wave sleepLeg movementsSleep timeTreatment of RLSMovement arousal indexNocturnal movement disordersSingle bedtime doseChronic hemodialysis patientsPeriodic limb movementsHours of sleepBedtime doseActive medicationHemodialysis patientsCrossover studyLegs syndromeUremic patientsArousal indexMovement disordersSleep disruptionFrequent dosingObjective improvementSleep disordersEffective treatmentEffect of severe gastroesophageal reflux on sleep stage in patients with aperistaltic esophagus
Shoenut J, Yamashiro Y, Orr W, Kerr P, Micflikier A, Kryger M. Effect of severe gastroesophageal reflux on sleep stage in patients with aperistaltic esophagus. Digestive Diseases And Sciences 1996, 41: 372-376. PMID: 8601385, DOI: 10.1007/bf02093831.Peer-Reviewed Original Research
1995
Sleep apnea a risk factor for poor driving.
Lertzman M, Wali S, Kryger M. Sleep apnea a risk factor for poor driving. Canadian Medical Association Journal 1995, 153: 1063. PMID: 7553506, PMCID: PMC1487308.Commentaries, Editorials and Letters
1993
Benzodiazepines in Congestive Heart Failure: Effects of Temazepam on Arousability and Cheyne-Stokes Respiration
Biberdorf D, Steens R, Millar T, Kryger M. Benzodiazepines in Congestive Heart Failure: Effects of Temazepam on Arousability and Cheyne-Stokes Respiration. Sleep 1993, 16: 529-538. PMID: 8235237, DOI: 10.1093/sleep/16.6.529.Peer-Reviewed Original ResearchConceptsCheyne-Stokes respirationCongestive heart failureTotal sleep timePercentage of TSTApnea/hypopnea indexOxygen saturationTotal wake timeEffects of temazepamHeart failureSleep architectureDouble-blind crossover trialSevere congestive heart failureOvernight oxygen saturationStage 1 sleepHours of sleepSleep stage proportionsCHF patientsHypopnea indexMale patientsDaytime somnolenceCrossover trialSignificant changesFrequent arousalsDaytime alertnessSleep timeEffects of Zolpidem and Triazolam on Sleep and Respiration in Mild to Moderate Chronic Obstructive Pulmonary Disease
Steens R, Pouliot Z, Millar T, Kryger M, George C. Effects of Zolpidem and Triazolam on Sleep and Respiration in Mild to Moderate Chronic Obstructive Pulmonary Disease. Sleep 1993, 16: 318-326. PMID: 8341892, DOI: 10.1093/sleep/16.4.318.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseModerate chronic obstructive pulmonary diseaseObstructive pulmonary diseaseEffects of zolpidemPulmonary diseaseDrug conditionsNocturnal arterial oxygen desaturationArterial oxygen desaturationApnea-hypopnea indexGroup of patientsArterial oxygen saturationNumber of awakeningsTotal sleep timeHours of sleepSignificant differencesSubjective sleep variablesNew hypnotic agentOxygen desaturationCrossover studyHypnotic agentsSleep problemsSleep qualityOxygen saturationSleep efficiencyActive drugSleep in nondepressed patients with panic disorder: II. Polysomnographic assessment of sleep architecture and sleep continuity
Stein M, Enns M, Kryger M. Sleep in nondepressed patients with panic disorder: II. Polysomnographic assessment of sleep architecture and sleep continuity. Journal Of Affective Disorders 1993, 28: 1-6. PMID: 8326076, DOI: 10.1016/0165-0327(93)90071-q.Peer-Reviewed Original ResearchConceptsPanic disorderAge-comparable healthy controlsNon-depressed patientsTotal sleep timeNondepressed patientsPolysomnographic assessmentDepressed patientsHealthy controlsMajor depressionSleep architectureSleep continuitySleep maintenanceDelta sleepEEG sleepPatientsNormal sleepSleep timeSleepDisordersModest reductionImpairment
1991
Subjective Versus Objective Evaluation of Hypnotic Efficacy: Experience with Zolpidem
Kryger M, Steljes D, Pouliot Z, Neufeld H, Odynski T. Subjective Versus Objective Evaluation of Hypnotic Efficacy: Experience with Zolpidem. Sleep 1991, 14: 399-407. PMID: 1759092, DOI: 10.1093/sleep/14.5.399.Peer-Reviewed Original ResearchConceptsTotal sleep timeSleep latencyNumber of awakeningsSleep timePSG findingsPersistent sleepHypnotic efficacySleep qualityPatients' subjective evaluationSubjective sleep qualityDecreased sleep latencyQuality of sleepShortened sleep latencyTotal wake timeObjective measuresPolysomnographic findingsSleepy patientsChronic insomniaWeeks' useIndividual patientsSleep efficiencySubjective reductionSubjective increaseObjective efficacyPatientsCentral sleep apnoea in congenital muscular dystrophy.
Kryger M, Steljes D, Yee W, Mate E, Smith S, Mahowald M. Central sleep apnoea in congenital muscular dystrophy. Journal Of Neurology Neurosurgery & Psychiatry 1991, 54: 710. PMID: 1940943, PMCID: PMC1014476, DOI: 10.1136/jnnp.54.8.710.Peer-Reviewed Original ResearchConceptsCentral sleep apnoeaSleep-disordered breathingCongenital muscular dystrophyMorning headachesSleep apnoeaNocturnal seizuresCongestive heart failureMuscular dystrophyPulmonary hypertensionClinical weaknessHeart failureExcessive daytimeNeuromuscular syndromeRespiratory dysfunctionNeuromuscular disordersApnoeaHeadacheSeizuresSymptomsBreathingDystrophyHypertensionDysfunctionSyndrome
1990
Cheyne-Stokes respiration in cardiac failure.
Kryger M, Hanly P. Cheyne-Stokes respiration in cardiac failure. Progress In Clinical And Biological Research 1990, 345: 215-24; discussion 224-6. PMID: 2377634.Peer-Reviewed Original Research
1989
The effect of oxygen on respiration and sleep in patients with congestive heart failure.
Hanly P, Millar T, Steljes D, Baert R, Frais M, Kryger M. The effect of oxygen on respiration and sleep in patients with congestive heart failure. Annals Of Internal Medicine 1989, 111: 777-82. PMID: 2817624, DOI: 10.7326/0003-4819-111-10-777.Peer-Reviewed Original ResearchConceptsStable congestive heart failureCheyne-Stokes respirationCongestive heart failureHeart failureTotal sleep timeOxygen therapySleep timeStage 1 NREM sleepPlacebo-controlled crossover studyLow-flow oxygenNocturnal oxygen saturationNocturnal oxygen therapyOutpatient cardiology clinicApnea-hypopnea indexNumber of arousalsStage 1 sleepStage 2 sleepSlow-wave sleepHyperpneic phaseNocturnal hypoxemiaSleep hypoxemiaMale patientsNasal cannulaeCardiology clinicCrossover studyRespiration and Abnormal Sleep in Patients with Congestive Heart Failure
Hanly B, Millar T, Steljes D, Boert R, Frais M, Kryger M. Respiration and Abnormal Sleep in Patients with Congestive Heart Failure. CHEST Journal 1989, 96: 480-488. PMID: 2766808, DOI: 10.1378/chest.96.3.480.Peer-Reviewed Original ResearchConceptsCheyne-Stokes respirationCongestive heart failureStage 2 NREM sleepSlow-wave sleepSleep stage changesNREM sleepHyperpneic phaseHeart failureREM sleepAwake arterial oxygen saturationStable congestive heart failureSevere congestive heart failureStage 1Mean minimum SaO2Outcomes of patientsNumber of arousalsArterial oxygen saturationStage 1 sleepMinimum SaO2Severe hypoxemiaArterial oxygenationSignificant hypoxemiaClinical statusMean durationAbnormal sleepThe Effect of L-Tryptophan on Daytime Sleep Latency in Normals: Correlation with Blood Levels
George C, Millar T, Hanly P, Kryger M. The Effect of L-Tryptophan on Daytime Sleep Latency in Normals: Correlation with Blood Levels. Sleep 1989, 12: 345-353. PMID: 2669092, DOI: 10.1093/sleep/12.4.345.Peer-Reviewed Original ResearchConceptsSleep latencyBlood levelsRandom double-blind fashionRapid eye movement (REM) sleepDaytime sleep latencyL-tryptophan's effectsDouble-blind fashionEye movement sleepL-tryptophanSlow-wave sleepL-tryptophan levelsObjective sleepiness measuresKynurenic acidMovement sleepHealthy volunteersWave sleepDrug conditionsSeparate daysSleepSleepiness measuresPlaceboSignificant correlationEssential amino acidsDoseUrine