2021
Comorbid Insomnia and Sleep Apnea: mechanisms and implications of an underrecognized and misinterpreted sleep disorder
Meira E Cruz M, Kryger MH, Morin CM, Palombini L, Salles C, Gozal D. Comorbid Insomnia and Sleep Apnea: mechanisms and implications of an underrecognized and misinterpreted sleep disorder. Sleep Medicine 2021, 84: 283-288. PMID: 34214960, DOI: 10.1016/j.sleep.2021.05.043.Peer-Reviewed Original ResearchMeSH KeywordsDisorders of Excessive SomnolenceHumansSleepSleep Apnea SyndromesSleep Initiation and Maintenance DisordersSleep Wake Disorders
2020
Danger!
Kryger MH. Danger! Sleep Health 2020, 6: 717. PMID: 33160902, DOI: 10.1016/j.sleh.2020.10.001.Commentaries, Editorials and Letters
2019
Greater health care utilization and cost associated with untreated sleep apnea.
Ding Q, Kryger M. Greater health care utilization and cost associated with untreated sleep apnea. Journal Of Clinical Sleep Medicine 2019, 16: 5-6. PMID: 31957652, PMCID: PMC7053011, DOI: 10.5664/jcsm.8152.Commentaries, Editorials and Letters
2012
Charles Dickens: impact on medicine and society.
Kryger M. Charles Dickens: impact on medicine and society. Journal Of Clinical Sleep Medicine 2012, 8: 333-8. PMID: 22701393, PMCID: PMC3365094, DOI: 10.5664/jcsm.1930.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSleep medicine: the shot heard around the world.
Kryger M. Sleep medicine: the shot heard around the world. Journal Of Clinical Sleep Medicine 2012, 8: 117-8. PMID: 22505853, PMCID: PMC3311405, DOI: 10.5664/jcsm.1754.Commentaries, Editorials and Letters
2008
The effects of ramelteon on respiration during sleep in subjects with moderate to severe chronic obstructive pulmonary disease
Kryger M, Roth T, Wang-Weigand S, Zhang J. The effects of ramelteon on respiration during sleep in subjects with moderate to severe chronic obstructive pulmonary disease. Sleep And Breathing 2008, 13: 79-84. PMID: 18584227, DOI: 10.1007/s11325-008-0196-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultComorbidityCross-Over StudiesDouble-Blind MethodFemaleHumansIndenesMaleOximetryPolysomnographyPulmonary Disease, Chronic ObstructiveReceptors, MelatoninSeverity of Illness IndexSleep Apnea SyndromesSleep Apnea, ObstructiveSleep Initiation and Maintenance DisordersSleep StagesYoung AdultConceptsSevere chronic obstructive pulmonary diseaseChronic obstructive pulmonary diseaseEffects of ramelteonObstructive pulmonary diseasePulmonary diseaseMean SaO2Respiratory depressant effectsApnea-hypopnea indexPoor sleep qualityTotal sleep timeMelatonin receptor agonistResultsNo significant differencesSignificant differencesAbnormal breathing eventsRamelteon 8Primary endpointAdverse eventsPersistent sleepCrossover studyDepressant effectPolysomnographic monitoringReceptor agonistRespiratory effortInsomnia treatmentSleep quality
2007
Directives de la Société Canadienne de Thoracologie: Diagnostic et Traitement des Troubles Respiratoires du Sommeil de L’Adulte
Fleetham J, Ayas N, Bradley D, Ferguson K, Fitzpatrick M, George C, Hanly P, Hill F, Kimoff J, Kryger M, Morrison D, Series F, Tsai W. Directives de la Société Canadienne de Thoracologie: Diagnostic et Traitement des Troubles Respiratoires du Sommeil de L’Adulte. Canadian Respiratory Journal 2007, 14: 31-36. PMID: 17315056, PMCID: PMC2690447, DOI: 10.1155/2007/592570.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2005
Increasing obesity trends in patients with sleep-disordered breathing referred to a sleep disorders center.
Banno K, Walld R, Kryger MH. Increasing obesity trends in patients with sleep-disordered breathing referred to a sleep disorders center. Journal Of Clinical Sleep Medicine 2005, 1: 364-6. PMID: 17564402, DOI: 10.5664/jcsm.26362.Peer-Reviewed Original ResearchConceptsSleep-related breathing disordersBody mass indexSleep disorders centerMean body mass indexDisorders CenterBMI unitsObesity trendsSleep-disordered breathingPrevalence of obesityTime of referralYear of referralNumber of patientsMale patientsFemale patientsMass indexBreathing disordersMean ageNew patientsPatientsSignificant positive correlationReferralWomenObesityRegression analysisSexLong-term treatment of sleep breathing disorder in a patient with Huntington's disease
Banno K, Hobson DE, Kryger MH. Long-term treatment of sleep breathing disorder in a patient with Huntington's disease. Parkinsonism & Related Disorders 2005, 11: 261-264. PMID: 15878590, DOI: 10.1016/j.parkreldis.2005.01.005.Peer-Reviewed Original ResearchMeSH KeywordsContinuous Positive Airway PressureElectromyographyFemaleHumansHuntington DiseaseMiddle AgedPolysomnographySleep Apnea SyndromesSleep, REMSnoringConceptsContinuous positive airway pressureSleep breathing disordersApnea-hypopnea indexBreathing disordersHuntington's diseaseRapid eye movement (REM) sleepPositive airway pressureObstructive sleep apneaLong-term treatmentEye movement sleepQuality of lifeAutosomal dominant neurodegenerative disorderAirway pressureHD patientsSleep apneaRespiratory arousalsMovement sleepDominant neurodegenerative disorderDaytime alertnessSleep structureNeurodegenerative disordersDiseaseDisordersApneaPatientsExperience in using split-day studies for suspected obstructive sleep apnea syndrome
Banno K, Al Sabbagh A, Delaive K, Higami S, Kryger MH. Experience in using split-day studies for suspected obstructive sleep apnea syndrome. Respiratory Medicine 2005, 99: 1334-1339. PMID: 16140233, DOI: 10.1016/j.rmed.2005.02.030.Peer-Reviewed Original ResearchMeSH KeywordsDelivery of Health CareFemaleHumansMaleMiddle AgedPolysomnographySleep Apnea SyndromesSleep Wake DisordersTime FactorsConceptsObstructive sleep apnea syndromeSleep apnea syndromeSleep breathing disordersApnea syndromeInconclusive studiesSevere obstructive sleep apnea syndromeSevere daytime sleepinessEligible casesBreathing disordersDefinitive diagnosisFinal diagnosisDaytime sleepinessMovement disordersSleep disordersSleep studiesPatientsSleep deprivationDiagnosisSubjective sleepinessAdditional assessmentDisordersInsufficient dataSyndromeSleepinessConclusive studiesAuto-Titrating Continuous Positive Airway Pressure for Heart Failure Patients With Cheyne-Stokes Respiration and Central Sleep Apnea
Banno K, Okamura K, Kryger MH. Auto-Titrating Continuous Positive Airway Pressure for Heart Failure Patients With Cheyne-Stokes Respiration and Central Sleep Apnea. Circulation Journal 2005, 69: 1295. PMID: 16200689, DOI: 10.1253/circj.69.1295.Peer-Reviewed Original ResearchMeSH KeywordsCheyne-Stokes RespirationHeart FailureHumansOximetryPositive-Pressure RespirationSleep Apnea Syndromes
2004
Factors limiting access to services for sleep apnea patients
Banno K, Kryger MH. Factors limiting access to services for sleep apnea patients. Sleep Medicine Reviews 2004, 8: 253-255. PMID: 15233953, DOI: 10.1016/j.smrv.2004.05.001.Peer-Reviewed Original Research
2002
Cardiovascular medication use in patients with undiagnosed obstructive sleep apnoea
Otake K, Delaive K, Walld R, Manfreda J, Kryger M. Cardiovascular medication use in patients with undiagnosed obstructive sleep apnoea. Thorax 2002, 57: 417. PMID: 11978918, PMCID: PMC1746332, DOI: 10.1136/thorax.57.5.417.Peer-Reviewed Original ResearchMeSH KeywordsBody Mass IndexCardiovascular AgentsDrug CostsElectrocardiographyElectromyographyFemaleHumansMaleMiddle AgedOdds RatioPolysomnographySleep Apnea SyndromesConceptsMore daily dosesCardiovascular diseaseSystemic hypertensionMedication usePrescribed medicationsDaily dosesMore prescriptionsOdds ratioSleep apnoea/hypopnoea syndromeUndiagnosed obstructive sleep apnoeaObstructive sleep apnoeaCardiovascular medication useCongestive heart failureUse of medicationsGeneral population controlsOSAS casesMore medicationsSecondary preventionAngina pectorisHeart failureSleep apnoeaMedication costsSuch medicationsMyocardial infarctionOSAS diagnosis
2000
Canadian Thoracic Society Guidelines: Diagnosis and Treatment of Sleep Disordered Breathing in Adults
Fleetham J, Ayas N, Bradley D, Ferguson K, Fitzpatrick M, George C, Hanly P, Hill F, Kimoff J, Kryger M, Morrison D, Series F, Tsai W, Committee T. Canadian Thoracic Society Guidelines: Diagnosis and Treatment of Sleep Disordered Breathing in Adults. Canadian Respiratory Journal 2000, 13: 387-392. PMID: 17036094, PMCID: PMC2683294, DOI: 10.1155/2006/627096.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsDiagnosis and management of sleep apnea syndrome
Kryger M. Diagnosis and management of sleep apnea syndrome. Clinical Cornerstone 2000, 2: 39-44. PMID: 10875045, DOI: 10.1016/s1098-3597(00)90039-5.Peer-Reviewed Original ResearchConceptsSleep apnea syndromeApnea syndromeContinuous positive airway pressureMain presenting symptomPositive airway pressureSleep breathing disordersConstellation of signsPresenting symptomAirway pressureMost patientsExcessive daytimeSleep apneaBreathing disordersAbnormal breathingComplete resolutionSleep disruptionBusy cliniciansSymptomsSyndromeSleepDiagnosisDisordersEpisodesHypoxemiaApnea
1999
Health Care Utilization in Males with Obstructive Sleep Apnea Syndrome Two Years After Diagnosis and Treatment
Bahammam A, Delaive K, Ronald J, Manfreda J, Roos L, Kryger M. Health Care Utilization in Males with Obstructive Sleep Apnea Syndrome Two Years After Diagnosis and Treatment. Sleep 1999, 22: 740-747. PMID: 10505819, DOI: 10.1093/sleep/22.6.740.Peer-Reviewed Original ResearchConceptsOSA patientsGeneral populationProspective observational cohort studyObservational cohort studySubgroup of patientsSleep disorders centerTreatment of patientsTwo yearsOSAS groupCohort studyPAT groupControl subjectsDisorders CenterPhysician claimsPatientsUtilization dataOne-yearDiagnosisYears one yearTreatmentYearsCanadian provincesOSASGroupHospitalUpper Airway Resistance Syndrome: Effect of Nasal Dilation, Sleep Stage, and Sleep Position
Bahammam A, Tate R, Manfreda J, Kryger M. Upper Airway Resistance Syndrome: Effect of Nasal Dilation, Sleep Stage, and Sleep Position. Sleep 1999, 22: 592-598. PMID: 10450594, DOI: 10.1093/sleep/22.5.592.Peer-Reviewed Original ResearchConceptsUpper airway resistance syndromeStage 1 sleepSleep positionNasal dilationDesaturation timeSleep architectureExternal nasal dilationArousal indexCardiorespiratory parametersSleep stagesNREM sleepNasal cross-sectional areaExternal nasal dilatorSlow-wave sleepObstructive sleepAirway collapsibilityConsecutive patientsNasal dilatorNasal obstructionResistance syndromeSupine positionIntrapharyngeal pressureIndirect markerWave sleepCrossover designClinical presentations of obstructive sleep apnea syndrome
Skomro R, Kryger M. Clinical presentations of obstructive sleep apnea syndrome. Progress In Cardiovascular Diseases 1999, 41: 331-340. PMID: 10406327, DOI: 10.1053/pcad.1999.0410331.Peer-Reviewed Original ResearchMeSH KeywordsDiagnosis, DifferentialFemaleHumansMaleMedical History TakingPhysical ExaminationSleep Apnea SyndromesSleep StagesConceptsObstructive sleep apnea syndromeSleep apnea syndromeQuality of lifeApnea syndromeClinical presentationTreatment of OSASClinical practiceBlood pressure controlIschemic heart diseaseHealth care professionalsMiddle-aged adultsCardiovascular morbidityPulmonary hypertensionMajor sequelaeUnderrecognized disorderCardiorespiratory failureDaytime somnolenceUpper airwayPrompt evaluationHeart diseaseRisk factorsClinical impressionNeurocognitive complaintsCare professionalsPressure controlHealth Care Utilization in the 10 Years Prior to Diagnosis in Obstructive Sleep Apnea Syndrome Patients
Ronald J, Delaive K, Roos L, Manfreda J, Bahammam A, Kryger M. Health Care Utilization in the 10 Years Prior to Diagnosis in Obstructive Sleep Apnea Syndrome Patients. Sleep 1999, 22: 225-229. PMID: 10201067, DOI: 10.1093/sleep/22.2.225.Peer-Reviewed Original ResearchMeSH KeywordsCanadaDatabases as TopicFemaleHealth ServicesHumansMaleMiddle AgedSleep Apnea SyndromesTime FactorsConceptsObstructive sleep apnea syndrome (OSAS) patientsSleep apnea syndrome patientsOSAS patientsSyndrome patientsHealth servicesHealth care utilizationHealth service utilizationInitial diagnostic evaluationHealth care resourcesHealth care servicesOvernight hospitalizationOSA patientsSuch patientsCare utilizationSleep apneaTime patientsRisk factorsService utilizationDiagnostic evaluationGeneral populationTobacco consumptionPatientsCare resourcesCare servicesAlcohol usageBlood Flow of the Middle Cerebral Artery With Sleep-Disordered Breathing: Correlation With Obstructive Hypopneas
Leslie W, Wali S, Kryger M. Blood Flow of the Middle Cerebral Artery With Sleep-Disordered Breathing: Correlation With Obstructive Hypopneas. Stroke 1999, 30: 188-90. PMID: 9880413, DOI: 10.1161/str.30.1.188/a.Peer-Reviewed Original Research