1998
Obstructive sleep apnea patients use more health care resources ten years prior to diagnosis.
Ronald J, Delaive K, Roos L, Manfreda J, Kryger M. Obstructive sleep apnea patients use more health care resources ten years prior to diagnosis. Sleep Research Online : SRO 1998, 1: 71-4. PMID: 11382859.Peer-Reviewed Original ResearchConceptsOSA patientsObstructive sleep apnea syndrome (OSAS) patientsHealth care utilization recordsPatient health care utilizationSleep apnea syndrome patientsObstructive sleep apnea patientsHealth care utilizationSleep apnea patientsOSAS patientsMore hospitalizationsCare utilizationApnea patientsOSAS diagnosisSyndrome patientsGeneral populationPatientsUtilization recordsTen yearsDiagnosisTen-year periodYearsTen-year intervalsComorbiditiesHospitalizationHeavy users
1989
The effect of oxygen on respiration and sleep in patients with congestive heart failure.
Hanly P, Millar T, Steljes D, Baert R, Frais M, Kryger M. The effect of oxygen on respiration and sleep in patients with congestive heart failure. Annals Of Internal Medicine 1989, 111: 777-82. PMID: 2817624, DOI: 10.7326/0003-4819-111-10-777.Peer-Reviewed Original ResearchConceptsStable congestive heart failureCheyne-Stokes respirationCongestive heart failureHeart failureTotal sleep timeOxygen therapySleep timeStage 1 NREM sleepPlacebo-controlled crossover studyLow-flow oxygenNocturnal oxygen saturationNocturnal oxygen therapyOutpatient cardiology clinicApnea-hypopnea indexNumber of arousalsStage 1 sleepStage 2 sleepSlow-wave sleepHyperpneic phaseNocturnal hypoxemiaSleep hypoxemiaMale patientsNasal cannulaeCardiology clinicCrossover studyThe Effect of L-Tryptophan on Daytime Sleep Latency in Normals: Correlation with Blood Levels
George C, Millar T, Hanly P, Kryger M. The Effect of L-Tryptophan on Daytime Sleep Latency in Normals: Correlation with Blood Levels. Sleep 1989, 12: 345-353. PMID: 2669092, DOI: 10.1093/sleep/12.4.345.Peer-Reviewed Original ResearchConceptsSleep latencyBlood levelsRandom double-blind fashionRapid eye movement (REM) sleepDaytime sleep latencyL-tryptophan's effectsDouble-blind fashionEye movement sleepL-tryptophanSlow-wave sleepL-tryptophan levelsObjective sleepiness measuresKynurenic acidMovement sleepHealthy volunteersWave sleepDrug conditionsSeparate daysSleepSleepiness measuresPlaceboSignificant correlationEssential amino acidsDoseUrine