2018
Flow limitation/obstruction with recovery breath (FLOW) event for improved scoring of mild obstructive sleep apnea without electroencephalography
Johnson KG, Johnson DC, Thomas RJ, Feldmann E, Lindenauer PK, Visintainer P, Kryger MH. Flow limitation/obstruction with recovery breath (FLOW) event for improved scoring of mild obstructive sleep apnea without electroencephalography. Sleep Medicine 2018, 67: 249-255. PMID: 30583916, PMCID: PMC6548700, DOI: 10.1016/j.sleep.2018.11.014.Peer-Reviewed Original ResearchConceptsApnea/hypopnea indexObstructive sleep apneaMild obstructive sleep apneaSleep apneaAirflow disruptionIntraclass correlationAHI categoriesBaseline PSGHypopnea indexOSA patientsHighest tertileOSA categoriesArousal criteriaPatientsFlow limitationApneaDesaturationFlow scoreArousal eventsOverall kappaObstructionTraining periodHigher proportionElectroencephalographyScoring
2007
Safety of ramelteon in individuals with mild to moderate obstructive sleep apnea
Kryger M, Wang-Weigand S, Roth T. Safety of ramelteon in individuals with mild to moderate obstructive sleep apnea. Sleep And Breathing 2007, 11: 159-164. PMID: 17294232, DOI: 10.1007/s11325-006-0096-4.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaNext-day residual effectsApnea-hypopnea indexSleep apneaPost-sleep questionnaireAdverse eventsSelective MT1/MT2 receptor agonistMT1/MT2 receptor agonistMT2 receptor agonistSafety of ramelteonUrinary tract infectionArterial oxygen saturationControl of breathingRespiratory inductance plethysmographyRamelteon groupPlacebo groupTract infectionsCrossover studyWashout periodDepressant effectSleep QuestionnaireHypopneic eventsRespiratory effortInsomnia treatmentOxygen saturation
1999
Upper Airway Resistance Syndrome: Effect of Nasal Dilation, Sleep Stage, and Sleep Position
Bahammam A, Tate R, Manfreda J, Kryger M. Upper Airway Resistance Syndrome: Effect of Nasal Dilation, Sleep Stage, and Sleep Position. Sleep 1999, 22: 592-598. PMID: 10450594, DOI: 10.1093/sleep/22.5.592.Peer-Reviewed Original ResearchConceptsUpper airway resistance syndromeStage 1 sleepSleep positionNasal dilationDesaturation timeSleep architectureExternal nasal dilationArousal indexCardiorespiratory parametersSleep stagesNREM sleepNasal cross-sectional areaExternal nasal dilatorSlow-wave sleepObstructive sleepAirway collapsibilityConsecutive patientsNasal dilatorNasal obstructionResistance syndromeSupine positionIntrapharyngeal pressureIndirect markerWave sleepCrossover design
1995
A Familial Awake Movement Disorder Mimicking Restless Legs in a Sleep Apnea Patient
Yamashiro Y, Chodirker B, Hobson D, Kryger M. A Familial Awake Movement Disorder Mimicking Restless Legs in a Sleep Apnea Patient. Sleep 1995, 18: 604-607. PMID: 8552932, DOI: 10.1093/sleep/18.7.604.Peer-Reviewed Original ResearchConceptsRestless legs syndromeMovement disordersFamilial movement disordersLegs syndromeSleep apneaNasal continuous positive airway pressureContinuous positive airway pressurePositive airway pressureObstructive sleep apneaPeriodic limb movementsSleep apnea syndromeSleep apnea patientsSleep onset insomniaSupine posturingAirway pressureObese menApnea syndromeLeg sensationsRestless legsNocturnal arousalsMean durationApnea patientsDaytime sleepinessSuccessful treatmentClinical significance
1993
Benzodiazepines in Congestive Heart Failure: Effects of Temazepam on Arousability and Cheyne-Stokes Respiration
Biberdorf D, Steens R, Millar T, Kryger M. Benzodiazepines in Congestive Heart Failure: Effects of Temazepam on Arousability and Cheyne-Stokes Respiration. Sleep 1993, 16: 529-538. PMID: 8235237, DOI: 10.1093/sleep/16.6.529.Peer-Reviewed Original ResearchConceptsCheyne-Stokes respirationCongestive heart failureTotal sleep timePercentage of TSTApnea/hypopnea indexOxygen saturationTotal wake timeEffects of temazepamHeart failureSleep architectureDouble-blind crossover trialSevere congestive heart failureOvernight oxygen saturationStage 1 sleepHours of sleepSleep stage proportionsCHF patientsHypopnea indexMale patientsDaytime somnolenceCrossover trialSignificant changesFrequent arousalsDaytime alertnessSleep timeSleep in nondepressed patients with panic disorder: II. Polysomnographic assessment of sleep architecture and sleep continuity
Stein M, Enns M, Kryger M. Sleep in nondepressed patients with panic disorder: II. Polysomnographic assessment of sleep architecture and sleep continuity. Journal Of Affective Disorders 1993, 28: 1-6. PMID: 8326076, DOI: 10.1016/0165-0327(93)90071-q.Peer-Reviewed Original ResearchConceptsPanic disorderAge-comparable healthy controlsNon-depressed patientsTotal sleep timeNondepressed patientsPolysomnographic assessmentDepressed patientsHealthy controlsMajor depressionSleep architectureSleep continuitySleep maintenanceDelta sleepEEG sleepPatientsNormal sleepSleep timeSleepDisordersModest reductionImpairment
1991
Subjective Versus Objective Evaluation of Hypnotic Efficacy: Experience with Zolpidem
Kryger M, Steljes D, Pouliot Z, Neufeld H, Odynski T. Subjective Versus Objective Evaluation of Hypnotic Efficacy: Experience with Zolpidem. Sleep 1991, 14: 399-407. PMID: 1759092, DOI: 10.1093/sleep/14.5.399.Peer-Reviewed Original ResearchConceptsTotal sleep timeSleep latencyNumber of awakeningsSleep timePSG findingsPersistent sleepHypnotic efficacySleep qualityPatients' subjective evaluationSubjective sleep qualityDecreased sleep latencyQuality of sleepShortened sleep latencyTotal wake timeObjective measuresPolysomnographic findingsSleepy patientsChronic insomniaWeeks' useIndividual patientsSleep efficiencySubjective reductionSubjective increaseObjective efficacyPatients
1990
Cheyne-Stokes respiration in cardiac failure.
Kryger M, Hanly P. Cheyne-Stokes respiration in cardiac failure. Progress In Clinical And Biological Research 1990, 345: 215-24; discussion 224-6. PMID: 2377634.Peer-Reviewed Original Research
1989
The effect of oxygen on respiration and sleep in patients with congestive heart failure.
Hanly P, Millar T, Steljes D, Baert R, Frais M, Kryger M. The effect of oxygen on respiration and sleep in patients with congestive heart failure. Annals Of Internal Medicine 1989, 111: 777-82. PMID: 2817624, DOI: 10.7326/0003-4819-111-10-777.Peer-Reviewed Original ResearchConceptsStable congestive heart failureCheyne-Stokes respirationCongestive heart failureHeart failureTotal sleep timeOxygen therapySleep timeStage 1 NREM sleepPlacebo-controlled crossover studyLow-flow oxygenNocturnal oxygen saturationNocturnal oxygen therapyOutpatient cardiology clinicApnea-hypopnea indexNumber of arousalsStage 1 sleepStage 2 sleepSlow-wave sleepHyperpneic phaseNocturnal hypoxemiaSleep hypoxemiaMale patientsNasal cannulaeCardiology clinicCrossover studyRespiration and Abnormal Sleep in Patients with Congestive Heart Failure
Hanly B, Millar T, Steljes D, Boert R, Frais M, Kryger M. Respiration and Abnormal Sleep in Patients with Congestive Heart Failure. CHEST Journal 1989, 96: 480-488. PMID: 2766808, DOI: 10.1378/chest.96.3.480.Peer-Reviewed Original ResearchConceptsCheyne-Stokes respirationCongestive heart failureStage 2 NREM sleepSlow-wave sleepSleep stage changesNREM sleepHyperpneic phaseHeart failureREM sleepAwake arterial oxygen saturationStable congestive heart failureSevere congestive heart failureStage 1Mean minimum SaO2Outcomes of patientsNumber of arousalsArterial oxygen saturationStage 1 sleepMinimum SaO2Severe hypoxemiaArterial oxygenationSignificant hypoxemiaClinical statusMean durationAbnormal sleep
1985
Sleep in Restrictive Lung Disorders
Kryger M. Sleep in Restrictive Lung Disorders. Clinics In Chest Medicine 1985, 6: 675-677. PMID: 3853479, DOI: 10.1016/s0272-5231(21)00404-4.Peer-Reviewed Original ResearchSleep and Respiration: Terminology and Methodology
West P, Kryger M. Sleep and Respiration: Terminology and Methodology. Clinics In Chest Medicine 1985, 6: 691-712. PMID: 3936667, DOI: 10.1016/s0272-5231(21)00406-8.ChaptersSleep and Control of Heart Rate
George C, Kryger M. Sleep and Control of Heart Rate. Clinics In Chest Medicine 1985, 6: 595-601. PMID: 3853478, DOI: 10.1016/s0272-5231(21)00397-x.Peer-Reviewed Original ResearchConceptsHeart rateTotal peripheral vascular resistanceSinus arrhythmiaExaggerated sinus arrhythmiaAutonomic nervous system activityPeripheral vascular resistanceTransient AV blockNormal hemoglobin concentrationAutonomic nervous activityNervous system activityHeart rate responseStages of sleepVascular resistanceBlood pressureVentricular functionCardiac outputAV blockRhythm disturbancesCarotid bodyLung inflationNervous activityREM sleepRespiratory arrhythmiaHemoglobin concentrationRespiratory rate
1982
Sleep, Arousals, and Oxygen Desaturation in Chronic Obstructive Pulmonary Disease
Fleetham J, West P, Mezon B, Conway W, Roth T, Kryger M. Sleep, Arousals, and Oxygen Desaturation in Chronic Obstructive Pulmonary Disease. American Journal Of Respiratory And Critical Care Medicine 1982, 126: 429-33. PMID: 7125332, DOI: 10.1164/arrd.1982.126.3.429.Peer-Reviewed Original ResearchConceptsOxygen desaturationArousal frequencySleep qualityChronic obstructive pulmonary diseaseAge-matched normal subjectsLower mean SaO2Role of hypoxemiaArterial oxygen desaturationObstructive pulmonary diseaseRoom air breathingArterial O2 saturationPoor sleep qualityReduced sleep timeSleep stage changesApneic episodesPulmonary functionOxygen therapyPulmonary diseaseSupplemental oxygenMean SaO2Sleep disruptionREM sleepNormal subjectsO2 saturationPatients