2008
Influence of Sex on Sleep Regulatory Mechanisms
Paul KN, Turek FW, Kryger MH. Influence of Sex on Sleep Regulatory Mechanisms. Journal Of Women's Health 2008, 17: 1201-1208. PMID: 18710368, DOI: 10.1089/jwh.2008.0841.Peer-Reviewed Original ResearchConceptsSleep regulatory mechanismsRodent studiesSleep-wake disordersReproductive hormonesExtended wakefulnessHomeostatic sleep regulatory mechanismsSleep consolidationSleep-wake amountsActivational influencesBiological sexRapid eye movement (REM) sleepSleep-wake architectureSleep amountSleep-wake cycleEffects of sexFemale reproductive hormonesSleepEye movement sleepSleep-wake statesInfluence of sexSleep disordersSleep statesPositive impactWakefulnessNeonatal exposure
1989
Heart Rate Response to Breath-Hold, Valsalva and Mueller Maneuvers in Obstructive Sleep Apnea
Hanly P, George C, Millar T, Kryger M. Heart Rate Response to Breath-Hold, Valsalva and Mueller Maneuvers in Obstructive Sleep Apnea. CHEST Journal 1989, 95: 735-739. PMID: 2924602, DOI: 10.1378/chest.95.4.735.Peer-Reviewed Original ResearchConceptsVoluntary respiratory maneuversObstructive sleep apneaHR responseSleep apneaRespiratory maneuversMueller maneuverOxygen saturationVagal toneAbsence of hypoxemiaArterial oxygen saturationHeart rate responseObstructive apneaMouth pressureApneaHR changesMale subjectsRate responseBreath holdSimilar durationValsalvaSignificant differencesSignificant correlationOSASMajor determinantWakefulness
1980
Chemical Control of Ventilation and Sleep Arterial Oxygen Desaturation in Patients with COPD1–3
Fleetham J, Mezon B, West P, Bradley C, Anthonisen N, Kryger M. Chemical Control of Ventilation and Sleep Arterial Oxygen Desaturation in Patients with COPD1–3. American Journal Of Respiratory And Critical Care Medicine 1980, 122: 583-9. PMID: 7436124, DOI: 10.1164/arrd.1980.122.4.583.Peer-Reviewed Original ResearchConceptsO2 saturationSleep desaturationVentilatory sensitivityRapid eye movement (REM) sleepNocturnal changesArterial oxygen desaturationLowest O2 saturationHypoxic ventilatory responseArterial O2 saturationEye movement sleepHypoxemic COPDNocturnal desaturationOxygen desaturationLung functionBlood gasesVentilatory responseMovement sleepVentilatory controlPatientsMaximal desaturationSleepDesaturationSleep stagesHypercapniaWakefulness