2023
International Consensus Statement on Obstructive Sleep Apnea
Chang JL, Goldberg AN, Alt JA, Mohammed A, Ashbrook L, Auckley D, Ayappa I, Bakhtiar H, Barrera J, Bartley B, Billings M, Boon M, Bosschieter P, Braverman I, Brodie K, Cabrera‐Muffly C, Caesar R, Cahali M, Cai Y, Cao M, Capasso R, Caples S, Chahine L, Chang C, Chang K, Chaudhary N, Cheong C, Chowdhuri S, Cistulli P, Claman D, Collen J, Coughlin K, Creamer J, Davis E, Dupuy‐McCauley K, Durr M, Dutt M, Ali M, Elkassabany N, Epstein L, Fiala J, Freedman N, Gill K, Gillespie M, Golisch L, Gooneratne N, Gottlieb D, Green K, Gulati A, Gurubhagavatula I, Hayward N, Hoff P, Hoffmann O, Holfinger S, Hsia J, Huntley C, Huoh K, Huyett P, Inala S, Ishman S, Jella T, Jobanputra A, Johnson A, Junna M, Kado J, Kaffenberger T, Kapur V, Kezirian E, Khan M, Kirsch D, Kominsky A, Kryger M, Krystal A, Kushida C, Kuzniar T, Lam D, Lettieri C, Lim D, Lin H, Liu S, MacKay S, Magalang U, Malhotra A, Mansukhani M, Maurer J, May A, Mitchell R, Mokhlesi B, Mullins A, Nada E, Naik S, Nokes B, Olson M, Pack A, Pang E, Pang K, Patil S, Van de Perck E, Piccirillo J, Pien G, Piper A, Plawecki A, Quigg M, Ravesloot M, Redline S, Rotenberg B, Ryden A, Sarmiento K, Sbeih F, Schell A, Schmickl C, Schotland H, Schwab R, Seo J, Shah N, Shelgikar A, Shochat I, Soose R, Steele T, Stephens E, Stepnowsky C, Strohl K, Sutherland K, Suurna M, Thaler E, Thapa S, Vanderveken O, de Vries N, Weaver E, Weir I, Wolfe L, Woodson B, Won C, Xu J, Yalamanchi P, Yaremchuk K, Yeghiazarians Y, Yu J, Zeidler M, Rosen I. International Consensus Statement on Obstructive Sleep Apnea. International Forum Of Allergy & Rhinology 2023, 13: 1061-1482. PMID: 36068685, PMCID: PMC10359192, DOI: 10.1002/alr.23079.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObstructive sleep apneaEvidence-based reviewPositive airway pressureInternational consensus statementSleep apneaConsensus statementAdult OSA patientsMultiple treatment modalitiesSleep apnea evaluationAirway pressureOSA patientsPAP adherenceSurgical treatmentEvidence-based practiceOSA treatmentLongitudinal careTreatment modalitiesClinical managementRisk factorsHealth risk outcomesStudy qualitySyndrome definitionCurrent evidenceRecommendation formatOSA disease
2016
Positive Airway Pressure Therapy for Obstructive Sleep Apnea
Weiss P, Kryger M. Positive Airway Pressure Therapy for Obstructive Sleep Apnea. Otolaryngologic Clinics Of North America 2016, 49: 1331-1341. PMID: 27720457, DOI: 10.1016/j.otc.2016.07.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPositive airway pressureObstructive sleep apneaAirway pressureSleep apneaMild obstructive sleep apneaPositive airway pressure therapyContinuous positive airway pressureSevere obstructive sleep apneaObstructive sleep apnea syndromeSleep-related breathing disordersConcomitant cardiovascular disordersAirway pressure therapyFirst-line therapySleep apnea syndromeAdaptive support ventilationEvaluation of adherenceEffectiveness of treatmentApnea syndromeSupport ventilationBreathing disordersPressure therapyCardiovascular disordersApneaTherapyPressure support
2014
Evaluation of a new pediatric positive airway pressure mask.
Kushida CA, Halbower AC, Kryger MH, Pelayo R, Assalone V, Cardell CY, Huston S, Willes L, Wimms AJ, Mendoza J. Evaluation of a new pediatric positive airway pressure mask. Journal Of Clinical Sleep Medicine 2014, 10: 979-84. PMID: 25142768, PMCID: PMC4153116, DOI: 10.5664/jcsm.4030.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePAP therapyPositive airway pressure maskPositive airway pressureParents/guardiansAirway pressureBaseline polysomnographyCPAP maskChildren's earsPressure maskPatientsAge groupsChildren's sleepUpper lipPolysomnographyChildrenTherapySleepEarYearsAHIClinicClinicians
2011
Positive Airway Pressure Initiation: A Randomized Controlled Trial to Assess the Impact of Therapy Mode and Titration Process on Efficacy, Adherence, and Outcomes
Kushida CA, Berry RB, Blau A, Crabtree T, Fietze I, Kryger MH, Kuna ST, Pegram GV, Penzel T. Positive Airway Pressure Initiation: A Randomized Controlled Trial to Assess the Impact of Therapy Mode and Titration Process on Efficacy, Adherence, and Outcomes. Sleep 2011, 34: 1083-1092. PMID: 21804670, PMCID: PMC3138163, DOI: 10.5665/sleep.1166.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureMinimum oxygen saturationAirway pressureFunctional outcomeOxygen saturationVeterans Affairs Medical CenterPositive pressure treatmentApnea-hypopnea indexObstructive sleep apneaSevere OSAMulticenter trialTreatment satisfactionControlled TrialsSleep apneaMajor efficacyStudy treatmentOutcome measuresMedical CenterSleep qualityTherapy modesMask comfortAdherenceEfficacyMonths
2007
Sleep apnea: Clinical investigations in humans
Banno K, Kryger MH. Sleep apnea: Clinical investigations in humans. Sleep Medicine 2007, 8: 400-426. PMID: 17478121, DOI: 10.1016/j.sleep.2007.03.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObstructive sleep apnea syndromeCentral sleep apnea syndromeContinuous positive airway pressureSleep apnea syndromeApnea syndromeApneic episodesTreatment of OSASDiagnosis of SASUpper airway obstructionPositive airway pressureMuscles of respirationCessation of breathingCentral nervous systemAirway obstructionAirway pressureHeart failureOral appliancesRespiratory driveImpaired qualityAbnormal breathingSubjective symptomsDaytime sleepinessCommon disorderMetabolic dysfunctionSleep disruption
2006
Healthcare Utilization in Women with Obstructive Sleep Apnea Syndrome 2 Years After Diagnosis and Treatment
Banno K, Manfreda J, Walld R, Delaive K, Kryger MH. Healthcare Utilization in Women with Obstructive Sleep Apnea Syndrome 2 Years After Diagnosis and Treatment. Sleep 2006, 29: 1307-1311. PMID: 17068984, DOI: 10.1093/sleep/29.10.1307.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeContinuous positive airway pressureClinic visitsHealthcare utilizationWeight lossTertiary university-based medical centerRetrospective observational cohort studyEntire groupUniversity-based medical centerTreatment-compliant patientsObservational cohort studyPositive airway pressureSleep apnea syndromeAirway pressureCohort studyCompliant patientsApnea syndromePhysician claimsMedical CenterWL groupGeneral populationPatientsDiagnosisVisitsWomenAdaptive servo-ventilation in patients with idiopathic Cheyne-Stokes breathing.
Banno K, Okamura K, Kryger MH. Adaptive servo-ventilation in patients with idiopathic Cheyne-Stokes breathing. Journal Of Clinical Sleep Medicine 2006, 2: 181-6. PMID: 17557493, DOI: 10.5664/jcsm.26514.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureCheyne-Stokes breathingHours of sleepHeart failureBreathing patternCentral sleep apneaPositive airway pressurePeriodic breathing patternAbnormal breathing patternsSerious medical problemSubjective daytime alertnessAbnormal breathing eventsAirway pressureRenal failureMedical illnessSleep apneaStokes breathingDaytime alertnessEffective treatmentPatientsSleep respirationBreathing eventsMedical problemsDaytime performanceBreathing
2005
Long-term treatment of sleep breathing disorder in a patient with Huntington's disease
Banno K, Hobson DE, Kryger MH. Long-term treatment of sleep breathing disorder in a patient with Huntington's disease. Parkinsonism & Related Disorders 2005, 11: 261-264. PMID: 15878590, DOI: 10.1016/j.parkreldis.2005.01.005.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureSleep breathing disordersApnea-hypopnea indexBreathing disordersHuntington's diseaseRapid eye movement (REM) sleepPositive airway pressureObstructive sleep apneaLong-term treatmentEye movement sleepQuality of lifeAutosomal dominant neurodegenerative disorderAirway pressureHD patientsSleep apneaRespiratory arousalsMovement sleepDominant neurodegenerative disorderDaytime alertnessSleep structureNeurodegenerative disordersDiseaseDisordersApneaPatientsAuto-Titrating Continuous Positive Airway Pressure for Heart Failure Patients With Cheyne-Stokes Respiration and Central Sleep Apnea
Banno K, Okamura K, Kryger MH. Auto-Titrating Continuous Positive Airway Pressure for Heart Failure Patients With Cheyne-Stokes Respiration and Central Sleep Apnea. Circulation Journal 2005, 69: 1295. PMID: 16200689, DOI: 10.1253/circj.69.1295.Peer-Reviewed Original Research
2003
Morbidity and mortality in obstructive sleep apnea syndrome 2: Effect of treatment on neuropsychiatric morbidity and quality of life
AL‐BARRAK M, SHEPERTYCKY M, KRYGER M. Morbidity and mortality in obstructive sleep apnea syndrome 2: Effect of treatment on neuropsychiatric morbidity and quality of life. Sleep And Biological Rhythms 2003, 1: 65-74. DOI: 10.1046/j.1446-9235.2003.00008.x.Peer-Reviewed Original ResearchContinuous positive airway pressureQuality of lifeNeuropsychiatric problemsObstructive sleep apnea syndrome (OSA) resultsAutomobile accident ratesNocturnal oxygen desaturationPositive airway pressureFragmentation of sleepEffect of treatmentOxygen desaturationAirway pressureOSA patientsResidual abnormalitiesCommon presentationNeuropsychiatric sequelaeNeuropsychiatric morbidityNeuropsychiatric abnormalitiesElectroencephalographic arousalSyndrome 2Syndrome resultsPatientsLife issuesMorbidityOSASAbnormalities
2000
Diagnosis and management of sleep apnea syndrome
Kryger M. Diagnosis and management of sleep apnea syndrome. Clinical Cornerstone 2000, 2: 39-44. PMID: 10875045, DOI: 10.1016/s1098-3597(00)90039-5.Peer-Reviewed Original ResearchConceptsSleep apnea syndromeApnea syndromeContinuous positive airway pressureMain presenting symptomPositive airway pressureSleep breathing disordersConstellation of signsPresenting symptomAirway pressureMost patientsExcessive daytimeSleep apneaBreathing disordersAbnormal breathingComplete resolutionSleep disruptionBusy cliniciansSymptomsSyndromeSleepDiagnosisDisordersEpisodesHypoxemiaApnea
1996
Treatment of Obstructive Sleep Apnea With a Self-Titrating Continuous Positive Airway Pressure (CPAP) System
Sharma S, Wali S, Pouliot Z, Peters M, Neufeld H, Kryger M. Treatment of Obstructive Sleep Apnea With a Self-Titrating Continuous Positive Airway Pressure (CPAP) System. Sleep 1996, 19: 497-501. PMID: 8865508, DOI: 10.1093/sleep/19.6.497.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureCPAP nightCPAP systemLowest arterial oxygen saturationObstructive sleep apnea syndromeContinuous positive airway pressure systemDiagnostic sleep studyNasal CPAP systemPositive airway pressureProspective clinical trialsObstructive sleep apneaSleep apnea syndromeSleep-disordered breathingArterial oxygen saturationMeasures of oxygenationTotal sleep timeLong-term useAirway pressureCPAP titrationSevere OSAAcute treatmentApnea syndromeSleep apneaArousal indexAirway stability
1995
Medical treatment of sleep apnea
Wali S, Kryger M. Medical treatment of sleep apnea. Current Opinion In Pulmonary Medicine 1995, 1: 498-503. PMID: 9363089, DOI: 10.1097/00063198-199511000-00012.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSleep apneaContinuous positive airway pressure therapyPositive airway pressure therapyContinuous positive airway pressureAirway pressure therapyPositive airway pressureObstructive sleep apneaCurrent treatment optionsTreatment of choiceAirway pressureNicotine treatmentPressure therapyTreatment optionsCommon disorderMedical treatmentDifficult patientsElectrical stimulationWeight lossDental appliancesApneaTherapyTreatmentUnwanted effectsTracheostomyPatientsSuccessful Treatment of Comorbid Panic Disorder and Sleep Apnea With Continuous Positive Airway Pressure
Enns M, Stein M, Kryger M. Successful Treatment of Comorbid Panic Disorder and Sleep Apnea With Continuous Positive Airway Pressure. Journal Of The Academy Of Consultation-Liaison Psychiatry 1995, 36: 585-586. PMID: 7501792, DOI: 10.1016/s0033-3182(95)71620-6.Peer-Reviewed Original ResearchA Familial Awake Movement Disorder Mimicking Restless Legs in a Sleep Apnea Patient
Yamashiro Y, Chodirker B, Hobson D, Kryger M. A Familial Awake Movement Disorder Mimicking Restless Legs in a Sleep Apnea Patient. Sleep 1995, 18: 604-607. PMID: 8552932, DOI: 10.1093/sleep/18.7.604.Peer-Reviewed Original ResearchConceptsRestless legs syndromeMovement disordersFamilial movement disordersLegs syndromeSleep apneaNasal continuous positive airway pressureContinuous positive airway pressurePositive airway pressureObstructive sleep apneaPeriodic limb movementsSleep apnea syndromeSleep apnea patientsSleep onset insomniaSupine posturingAirway pressureObese menApnea syndromeLeg sensationsRestless legsNocturnal arousalsMean durationApnea patientsDaytime sleepinessSuccessful treatmentClinical significanceThe Effects of Posture Change and Continuous Positive Airway Pressure on Cardiac Natriuretic Peptides in Congestive Heart Failure
Wilkins M, Su X, Palayew M, Yamashiro Y, Bolli P, McKenzie J, Kryger M. The Effects of Posture Change and Continuous Positive Airway Pressure on Cardiac Natriuretic Peptides in Congestive Heart Failure. CHEST Journal 1995, 107: 909-915. PMID: 7705152, DOI: 10.1378/chest.107.4.909.Peer-Reviewed Original ResearchConceptsCongestive heart failureAtrial natriuretic peptideN-CPAP therapyN-CPAPNatriuretic peptideHeart failureANP concentrationNasal continuous positive airway pressure therapyContinuous positive airway pressure therapyChronic congestive heart failureMean plasma ANP concentrationPositive airway pressure therapyContinuous positive airway pressureUpright postureAirway pressure therapyPositive airway pressureMean levelsPeripheral plasma levelsPlasma ANP concentrationCardiac natriuretic peptidesAirway pressureBNP concentrationsPressure therapyPlasma levelsPatients
1994
The Effect of Nasal CPAP on Nocturnal Reflux in Patients With Aperistaltic Esophagus
Shoenut J, Kerr P, Micflikier A, Yamashiro Y, Kryger M. The Effect of Nasal CPAP on Nocturnal Reflux in Patients With Aperistaltic Esophagus. CHEST Journal 1994, 106: 738-741. PMID: 8082351, DOI: 10.1378/chest.106.3.738.Peer-Reviewed Original ResearchConceptsNocturnal refluxNasal CPAPAperistaltic esophagusLES pressureReflux eventsNasal continuous positive airway pressureContinuous positive airway pressureLower esophageal sphincter pressurePositive airway pressureEsophageal sphincter pressureGroup of patientsScleroderma esophagusScleroderma groupAirway pressureSphincter pressureSleep apneaPercentage of timeCPAPPatientsSecond nightRefluxEsophagusFirst nightAchalasiaGroupWhy Should Sleep Apnea Be Diagnosed and Treated?
Yamashiro Y, Kryger M. Why Should Sleep Apnea Be Diagnosed and Treated? Clinical Pulmonary Medicine 1994, 1: 250-259. DOI: 10.1097/00045413-199407000-00007.Peer-Reviewed Original ResearchNasal continuous positive airway pressureObstructive sleep apneaSevere sequelaeRepetitive upper airway obstructionsContinuous positive airway pressureUpper airway obstructionPositive airway pressureTreatment of choiceGoal of treatmentPrimary pathophysiologic eventEffect of treatmentAirway obstructionAirway pressureSevere complicationsPatients' qualitySleep apneaMultisystem dysfunctionPathophysiologic eventsCommon disorderUndiagnosed patientsSevere casesSequelaePatient's lifeApneaPatientsAcute Effect of Nasal CPAP on Periodic Limb Movements Associated with Breathing Disorders During Sleep
Yamashiro Y, Kryger M. Acute Effect of Nasal CPAP on Periodic Limb Movements Associated with Breathing Disorders During Sleep. Sleep 1994, 17: 172-175. PMID: 8036372, DOI: 10.1093/sleep/17.2.172.Peer-Reviewed Original ResearchConceptsNasal continuous positive airway pressurePeriodic limb movementsSleep-disordered breathingPLMS indexAcute effectsContinuous positive airway pressureLimb movementsSplit-night protocolPositive airway pressureNCPAP treatmentNasal CPAPAirway pressureBreathing disordersBreathingTreatmentFuture investigationsApneaCPAPPatientsSleep
1993
Nasal Continuous Positive Airway Pressure
Kerr P, Shoenut J, Steens R, Millar T, Micflikier A, Kryger M. Nasal Continuous Positive Airway Pressure. Journal Of Clinical Gastroenterology 1993, 17: 276-280. PMID: 8308210, DOI: 10.1097/00004836-199312000-00002.Peer-Reviewed Original ResearchConceptsNasal continuous positive airway pressureContinuous positive airway pressureNocturnal gastroesophageal refluxLower esophageal pressurePositive airway pressureGastroesophageal refluxReflux patientsAirway pressureEsophageal pressureObstructive sleep apnea syndrome (OSAS) patientsSleep apnea syndrome patientsMean reflux durationNon-OSA patientsHealthy adult volunteersCPAP effectsNocturnal refluxEsophageal manometryMean durationIntraesophageal pressureLongest refluxSyndrome patientsHealthy volunteersReflux durationPatientsAdult volunteers