2003
Morbidity and mortality in obstructive sleep apnea syndrome 1: Effect of treatment on cardiovascular morbidity
SHEPERTYCKY M, AL‐BARRAK M, KRYGER M. Morbidity and mortality in obstructive sleep apnea syndrome 1: Effect of treatment on cardiovascular morbidity. Sleep And Biological Rhythms 2003, 1: 15-28. DOI: 10.1046/j.1446-9235.2003.00003.x.Peer-Reviewed Original ResearchObstructive sleep apnea syndromeSevere cardiovascular outcomesCongestive heart failureIschemic heart diseaseCardiovascular morbidityHeart failureCardiovascular outcomesPulmonary hypertensionSystemic hypertensionHeart diseaseCardiac arrhythmiasContinuous positive airway pressure (CPAP) treatmentPositive airway pressure treatmentOngoing population-based studyLarge ongoing trialsUntreated OSAS patientsIndependent risk factorDevelopment of hypertensionEpisodes of apneaSleep apnea syndromePopulation-based studyEffect of treatmentNocturnal hypoxemiaOSA patientsOSAS patients
2002
What Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis?
Smith R, Ronald J, Delaive K, Walld R, Manfreda J, Kryger MH. What Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis? CHEST Journal 2002, 121: 164-172. PMID: 11796446, DOI: 10.1378/chest.121.1.164.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeBody mass indexChronic obstructive airways diseaseObstructive airways diseaseHealth care utilizationSleep apnea patientsControl subjectsApnea patientsAirway diseaseOSAS patientsCardiovascular diseaseObstructive sleep apnea patientsHealth care utilization measuresApnea-hypopnea indexCongestive heart failureEffect of obesityIschemic heart diseaseSleep apnea syndromeDegree of hypoxemiaSignificant independent predictorsLogistic regression analysisCertain cardiovascular disordersHealth care resourcesRegression analysisApnea syndrome
1999
Health Care Utilization in the 10 Years Prior to Diagnosis in Obstructive Sleep Apnea Syndrome Patients
Ronald J, Delaive K, Roos L, Manfreda J, Bahammam A, Kryger M. Health Care Utilization in the 10 Years Prior to Diagnosis in Obstructive Sleep Apnea Syndrome Patients. Sleep 1999, 22: 225-229. PMID: 10201067, DOI: 10.1093/sleep/22.2.225.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndrome (OSAS) patientsSleep apnea syndrome patientsOSAS patientsSyndrome patientsHealth servicesHealth care utilizationHealth service utilizationInitial diagnostic evaluationHealth care resourcesHealth care servicesOvernight hospitalizationOSA patientsSuch patientsCare utilizationSleep apneaTime patientsRisk factorsService utilizationDiagnostic evaluationGeneral populationTobacco consumptionPatientsCare resourcesCare servicesAlcohol usage
1998
Obstructive sleep apnea patients use more health care resources ten years prior to diagnosis.
Ronald J, Delaive K, Roos L, Manfreda J, Kryger M. Obstructive sleep apnea patients use more health care resources ten years prior to diagnosis. Sleep Research Online : SRO 1998, 1: 71-4. PMID: 11382859.Peer-Reviewed Original ResearchConceptsOSA patientsObstructive sleep apnea syndrome (OSAS) patientsHealth care utilization recordsPatient health care utilizationSleep apnea syndrome patientsObstructive sleep apnea patientsHealth care utilizationSleep apnea patientsOSAS patientsMore hospitalizationsCare utilizationApnea patientsOSAS diagnosisSyndrome patientsGeneral populationPatientsUtilization recordsTen yearsDiagnosisTen-year periodYearsTen-year intervalsComorbiditiesHospitalizationHeavy users
1992
Nasal CPAP Reduces Gastroesophageal Reflux in Obstructive Sleep Apnea Syndrome
Kerr P, Shoenut J, Millar T, Buckle P, Kryger M. Nasal CPAP Reduces Gastroesophageal Reflux in Obstructive Sleep Apnea Syndrome. CHEST Journal 1992, 101: 1539-1544. PMID: 1600771, DOI: 10.1378/chest.101.6.1539.Peer-Reviewed Original ResearchConceptsNocturnal gastroesophageal refluxGastroesophageal refluxNasal CPAPIntrathoracic pressureNasal continuous positive airway pressureObstructive sleep apnea syndrome (OSAS) patientsContinuous positive airway pressureSleep apnea syndrome patientsObstructive sleep apnea syndromePositive airway pressureSleep apnea syndromeEsophageal pressure recordingAntireflux therapyGER frequencyAirway pressureOSAS patientsApnea syndromeClinical impressionSyndrome patientsPressure recordingsCPAPPatientsConsecutive daysNight twoMean percentageThe importance of nasal resistance in obstructive sleep apnea syndrome.
Kerr P, Millar T, Buckle P, Kryger M. The importance of nasal resistance in obstructive sleep apnea syndrome. Journal Of Otolaryngology 1992, 21: 189-95. PMID: 1404570.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeUpper airway collapseSleep apnea syndromeNasal resistanceOSAS patientsApnea syndromeAirway collapseAmount of apneaArousals/hourChronic nasal obstructionNasal airflow resistanceBaseline data collectionNocturnal oxygenationOSAS populationTopical vasoconstrictorOSAS severityNasal obstructionClinical evidenceNocturnal polysomnographyPSG studiesSubjective improvementPosterior rhinomanometryElevated nasal resistanceConditions of baselineSleep architecture